Ge advance pet scanner

PET/CT was performed using a GEADVANCE PET scanner (GE, Milwaukee, WI, USA) after the intravenous injection of 7–9 mCi of ¹⁸F-FDG. All patients fasted for at least 6 h before the test. Emission scanning was continued for 15 min (4.25-mm axial spatial resolution, 4.8-mm transaxial spatial resolution). Transmission scans were performed for 8 min using triple Ge-68 rod sources to correct attenuation. Gathered data were reconstructed in a 128 × 128 × 35 matrix with a pixel size of 1.95 × 1.95 × 4.25 mm by means of a filtered back-projection algorithm employing a transaxial 8.5-mm Hanning filter and 8.5-mm axial ramp filter. Two specialists independently interpreted the encoded baseline PET images, and after a two-week period, they interpreted the encoded post DEX suppression PET images. Each specialist was blinded to MRI imaging, clinical characteristics, and surgical outcomes of these subjects. Each was tasked with determining whether the PET image indicated a “negative” or “positive” result for pituitary adenoma and its location on a high-resolution computer screen.
The scan after DEX suppression was performed 24 h after the oral administration of 8 mg of DEX using the same procedures as for the baseline PET/CT scan.

Imaging was performed at baseline. Details of the MRI and PET acquisition and analysis have been published previously.^{23 (link)
25} In summary, PET-Aβ imaging data were available for 59 participants with LBD. For the NIMROD and MILOS cohort 550 MBq of [11^C] PIB PET imaging was carried out using a GE Advance PET scanner (GE Healthcare) or a GE Discovery 690 PET/CT, with attenuation correction provided by a transmission scan or a low dose CT scan, with 550 MBq of PIB injected as a bolus and imaging performed for 30 min starting at 40 min post injection. Participants were considered PET-Aβ-positive using a cutpoint of 19 on the centiloid scale.^{28 (link)}For the AMPLE cohort imaging was performed using a Siemens Biograph-40 PET-CT scanner. Participants were given a 370 MBq intravenous injection of ¹⁸F-florbetapir (Amyvid). PET imaging was carried out for 15 min, commencing 30−50 min after injection. Attenuation correction was performed using CT scan data. Amyloid PET images were visually rated as positive or negative based on the manufacturer’s criteria by a panel of five raters.^{23 (link)}

PET images were obtained (GE Advance PET scanner, GE Medical Systems, Inc.) after patients had fasted for four or more hours and then received an intravenous injection of 7–10 mCi (259–370 MBq) of FDG. EEG during the uptake period demonstrated no EEG seizure activity in any patient. Hypometabolism was determined semi-quantitatively by visual assessment using calibrated color scales with a high or absolute degree of inter-observer agreement. A graduated color scale in 2% increments was used for display and analyses. When the metabolism of the lobe showed a 20% or more reduction compared with the other areas of metabolism, it was regarded as abnormal hypometabolism.[13 (link),21 (link)]