Deuterated solvent

All reactions and manipulations were carried out under normal atmospheric conditions unless otherwise stated. GeCl₂·Dioxane was purchased from Strem Chemicals. Acetylacetone was purchased from Sigma Aldrich and used as received. l-glutathione and N-acetyl cysteine were purchased from Alfa Aesar. All other solvents were of ACS grade and used as commercially available. Deuterated solvents were purchased from Cambridge Isotope Laboratories (Andover, MA). 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and 2′,7′ –dichlorofluorescin diacetate (DCF-DA), and JC-1 were purchased from Cayman Chemicals. We utilized ACS grade solvents, which were purchased from Pharmco-Aaper and used without further purification or drying. Deuterated solvents were purchased from Cambridge Isotope Laboratories and used as received. Silica gel for column chromatography (Silicycle, P/N: R10030B SiliaFlash®F60, Size: 40–63 μm, Canada) was purchased from Silicycle. Aluminum backed silica-gel plates (20 × 20 cm²) were purchased from Silicycle (TLA-R10011B-323) and utilized for analytical thin-layer chromatography (TLC). Filtrations were carried out using medium-porosity ceramic funnels. Removal of solvents in vacuo was performed using a Büchi rotary evaporator and further drying was achieved by Schlenk line at ~120 mTorr using a dynamic vacuum pump.

All reagents and solvents for synthesis were obtained from Sigma- Aldrich, St. Louis, MO, USA. Triethylamine was dried by refluxing CaH₂, followed by distillation and storage over 4Å molecular sieves. Deuterated solvents were acquired from Cambridge Isotope Laboratories (CIL). Purification was performed using 60 mesh standard silica from Sorbtech. ¹H NMR (300 MHz) and ¹³C NMR (100 MHz) spectra were recorded at 25°C on Varian Mercury spectrometers. Chemical shifts (δ) are given in ppm relative to TMS as an internal standard or the respective NMR solvent. Mass spectra were recorded on Thermo Fisher Scientific Exactive Plus MS (ESI).