Sodium hydroxide solution 1 n

Losartan potassium (Form I, Dr. Reddy’s Laboratories, Jinnaram Mandal, Telangana, India), silicified microcrystalline cellulose (PROSOLV^® SMCC 50, JRS Pharma, Rosenberg, Germany), copovidone (Kollidon^® VA 64 (Fine), BASF Pharma, Ludwigshafen, Germany), crospovidone (Kollidon^® CL, BASF, Ludwigshafen, Germany), dicalciumphosphate anhydrous (DI-CAFOS^® A 150, Chemische Fabrik Budenheim, Budenheim, Germany), lactose (Tablettose^® 80, Flowlac^® 100, MEGGLE, Wasserburg am Inn, Germany), isomalt (galenIQ^TM 721, BENEO-Palatinit, Mannheim, Germany), microcrystalline cellulose (VIVAPUR^® 102, JRS Pharma, Rosenberg, Germany), Ludipress^® (BASF Pharma, Ludwigshafen, Germany), magnesium stearate (Parteck^® LUB MST, Merck, Darmstadt, Germany), sodium stearyl fumarate (PRUV^®, JRS Pharma, Rosenberg, Germany), talc (Talkum^® Pharma G, C.H. Erbslöh, Krefeld, Germany), HPMC (PHARMACOAT^® 603, Shin-Etsu Chemical, Tokyo, Japan), macrogol (PEG 6000, BASF Pharma, Ludwigshafen, Germany), methanol (HPLC grade, VWR Chemicals, Radnor, PA, USA), acetonitrile (HPLC grade, Honeywell, Charlotte, NC, USA), phosphoric acid (Merck, Darmstadt, Germany), monobasic potassium phosphate (Fisher Scientific, Waltham, MA, USA), disodium hydrogen phosphate anhydrous (AppliChem, Darmstadt, Germany), and sodium hydroxide solution 1 N (Merck, Darmstadt, Germany) were used.

Sodium chloride and hexane (≥95%) were obtained from Fisher Scientific (Pittsburgh, PA, USA). Sodium sulphate (anhydrous) was obtained from ECP-Analytical (Auckland, New Zealand). 4-Decanone* (≥97.0%) was obtained from Tokyo Chemical Company (Tokyo, Japan). 4-Methyl-2-pentanone* (≥98%) was obtained from BDH Chemicals Ltd. (Poole, UK). Dichloromethane (≥99.9%), methanol (≥99.8%), sodium hydroxide solution (1N), 3-octanone (≥98%), δ-octalactone (98%), γ-decalactone (≥98%), δ-decalactone (≥98%), γ-dodecalactone (≥97%), δ-dodecalactone (≥97%), δ-tetradecalactone (98%) were obtained from Merck (Darmstadt, Germany). A C₇-C₃₀ Saturated Alkane Standard was obtained from Supelco (Bellefonte, PA, USA). Liquid nitrogen, liquid carbon dioxide, hydrogen carrier gas (instrument grade, >99.98%), and nitrogen (instrument grade, >99.99%) were obtained from BOC Ltd. (Auckland, New Zealand).