Nicotine bitartrate (MP Biomedicals; Solon, OH, USA) and varenicline dihydrochloride (a gift from NIDA Drug Supply Program; Bethesda; MD, USA), were dissolved in 0.9 % sterile saline. Doses and administration protocols were adopted from previous research (Charntikov et al., 2017 (link); George et al., 2011 (link); Kazan et al., 2020 (link); Wouda et al., 2011 (link)). Nicotine doses are reported as base, whereas varenicline doses are reported as salt. The pH of nicotine was adjusted to 7.0 ± 0.2 with a dilute NaOh solution. All drugs were administered at 1 ml/kg.
Nicotine bitartrate
Manufactured by MP Biomedicals
Sourced in United States
Nicotine bitartrate is a chemical compound that serves as a laboratory reagent. It is a salt formed by the combination of nicotine and tartaric acid. This product is used for various research and analytical applications in life science laboratories.
Automatically generated - may contain errors
6 protocols using nicotine bitartrate
1
Nicotine and Varenicline Dosing Protocol
2
Nicotine Preparation and Dosing
3
Pharmacological Manipulation of Nicotine Responses
4
Nicotine Bitartrate Dosing Protocol
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Nicotine bitartrate (MP Biomedicals; Solon, OH, USA) was dissolved in 0.9 % sterile saline. The pH of nicotine was adjusted to 7.0 ± 0.2 with a dilute NaOH solution. Nicotine doses are reported as a base. Doses and administration protocols were adopted from previous research (Charntikov et al., 2014; Kazan and Charntikov, 2019; Liu et al., 2008) .
5
Nicotine Pharmacokinetics in Rodents
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Nicotine bi-tartrate purchased from MP Biomedical (Solon, Ohio) and dissolved in normal saline or drinking water prior to use each day. The drug was injected subcutaneously or placed in the drinking water at the doses and concentrations described below. The concentrations and doses of nicotine were all as the salt form of the drug.
6
Nicotine and Cocaine Administration in Mice
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Nicotine bi-tartrate obtained from MP biomedical (Solon, Ohio) was dissolved in saline and administered subcutaneously (s.c.). Cocaine hydrochloride obtained from Sigma/Aldrich (St. Louis, Missouri) was dissolved in saline and administered intraperitoneally (i.p.). Control mice were injected with saline (s.c. and/or i.p.). The dose of nicotine is as the bi-tartrate salt.
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