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Duloxetine hydrochloride

Manufactured by Fujifilm
Sourced in Japan

Duloxetine hydrochloride is a chemical compound used as a raw material in the production of certain pharmaceutical products. It is a white to off-white crystalline powder. The core function of duloxetine hydrochloride is to serve as an intermediate in the synthesis of active pharmaceutical ingredients, but its specific applications or intended uses are not included in this factual description.

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2 protocols using duloxetine hydrochloride

1

Assessment of Antidepressant Drug Effects

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Ham’s F-12K medium (F-12K), sertraline hydrochloride, paroxetine hydrochloride, duloxetine hydrochloride, fluvoxamine maleate, and mirtazapine were obtained from Fujifilm Wako Pure Chemical Industries Ltd. (Osaka, Japan). Escitalopram oxalate, venlafaxine hydrochloride, and 2′,7′-dichlorofluorescin diacetate (DCFDA) were obtained from Sigma-Aldrich, Inc. (St. Louis, MO, USA). Fetal bovine serum (FBS) was purchased from Thermo Fisher Scientific (Waltham, MA, USA). Apotracker Green (Apo-15) and Calcein Red-acetoxymethyl ester (Calcein Red-AM) were purchased from BioLegend, Inc. (San Diego, CA, USA). All other chemicals used in the study were of the highest purity available. The 96-well plates were obtained from Corning (Corning, NY, USA).
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2

In Vitro Interactions of Duloxetine and MgO

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In the in vivo experiment, we used duloxetine capsules, containing enteric-coated duloxetine granules (Cymbalta ® ; Shionogi & Co., Ltd., Osaka, Japan), a duloxetine reagent (Sigma-Aldrich Japan, Tokyo, Japan), and MgO (Sigma-Aldrich Japan).
To assess the in vitro interactions that take place between duloxetine solutions and MgO, we used duloxetine hydrochloride (Wako Pure Chemical Industries, Ltd., Osaka, Japan) and MgO (Sigma-Aldrich Japan). Each chemical was dissolved or suspended in distilled water.
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