The in vitro dissolution study was carried using a USP type II dissolution apparatus (Erweka). The study was carried out in 500 mL pH 6.8 phosphate-buffered solution or pH 1.2 0.1 N HCl as dissolution media maintained at 37°C±0.5°C and 50 rpm. Samples (5 mL) were collected at 2-, 5-, 10-, 15-, and 30-minute intervals. Samples were recompensed using fresh preheated media. Samples were analyzed using an ultraviolet spectrophotometer (PD-303UV; Apel Co Ltd, Kawaguchi, Japan) at 232 nm. Each test was performed in triplicate.
Usp type 2 dissolution apparatus
Manufactured by Erweka
Sourced in Germany
The USP type II dissolution apparatus is a piece of lab equipment used to measure the dissolution rate of solid oral dosage forms, such as tablets and capsules, in a controlled environment. It consists of a water bath, a set of rotating paddles, and a series of vessels where the samples are placed. The apparatus operates in accordance with the United States Pharmacopeia (USP) standards for dissolution testing, providing a standardized method for evaluating the release of active pharmaceutical ingredients from drug products.
Automatically generated - may contain errors
Lab products found in correlation
2 protocols using usp type 2 dissolution apparatus
1
In Vitro Dissolution Study of Pharmaceutical Formulations
2
Dissolution Profiling of Drug Formulations
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
The release of drug from the dosage from was assessed under dissolution test by using USP type-II dissolution apparatus (Erweka, Germany), operated at 100 rpm in 900 mL of 0.1 HCl at pH-1.2 maintained at 37±0.5°C. The selected formulations (F1, F4, F8 and F11) were also evaluated in phosphate buffer at pH 4.5 and 6.8 maintained at same temperature. 5 ml of the sample was withdrawn at regular intervals of 1, 2, 3, 4, 6, 8, 10 and 12 hrs and replaced with the same volume of pre-warmed (37±0.5°C) fresh dissolution medium. The drug content in each sample was analyzed after suitable dilution using UV spectrophotometer method at 276 nm 24 .
About PubCompare
Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.
We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.
However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.
Ready to get started?
Sign up for free.
Registration takes 20 seconds.
Available from any computer
No download required
Revolutionizing how scientists
search and build protocols!