Kollidon 90f

Manufactured by BASF

Sourced in Germany

Kollidon 90F is a polyvinylpyrrolidone (PVP) polymer produced by BASF. It is a fine, white, free-flowing powder with a high molecular weight. Kollidon 90F is commonly used as an excipient in pharmaceutical formulations and as a binder in tablet production.

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Lab products found in correlation

Glacial acetic acid, by Avantor (1 mentions) L13152 live dead baclight bacterial viability kit, by Thermo Fisher Scientific (1 mentions) Staphylococcus aureus atcc 29213, by American Type Culture Collection (1 mentions) Furosemide fur, by Merck Group (1 mentions) Kollicoat sr 30d, by BASF (1 mentions) Eudragit rs po, by Evonik (1 mentions) Kollidon va64, by BASF (1 mentions) Hydrocortisone, by Merck Group (1 mentions) Pemulen tr2 nf, by Lubrizol (1 mentions) Eudragit nm 30d, by Evonik (1 mentions) Purasorbpdlg 5010, by Corbion (1 mentions) Pirfenidone, by Tokyo Chemical Industry (1 mentions) Lyrica capsules, by Pfizer (1 mentions) Vivapur 12, by JRS Pharma (1 mentions) D mannitol, by Roquette (1 mentions) Fitc dx, by Merck Group (1 mentions) Avastin, by Roche (1 mentions) Sodium phosphate dibasic dihydrate, by Merck Group (1 mentions) Sodium dihydrogen phosphate, by Merck Group (1 mentions) Kollicoat ir, by BASF (1 mentions)

8 protocols using kollidon 90f

Antimicrobial PVC Sheets Evaluation

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Medical-grade unplasticized PVC sheets were
purchased from Goodfellow Cambridge Ltd. (Huntingdon, UK). Acetic
acid glacial was purchased from VWR Chemicals (Lutterworth, UK). The
SYLGARD 184 elastomer kit was purchased from Dow Corning Corporation
(Midland, UK). Kollidon 90F was purchased from BASF (Ludwigshafen,
Germany). Escherichia coli (E. coli, ATCC 25922) and Staphylococcus
aureus (ATCC 29213) were obtained from the American
Type Culture Collection (ATCC, Buckinghamshire, UK). The LIVE/DEAD
BacLight Bacterial Viability Kit L13152 was purchased from Thermo
Fisher Scientific (Paisley, UK). Other chemicals used in this study
were purchased from Merck Life Science UK Ltd. (Dorset, UK) without
further purification.

Teng X., Yao C., McCoy C.P, & Zhang S. (2024). Comparison of Superhydrophilic, Liquid-Like, Liquid-Infused, and Superhydrophobic Surfaces in Preventing Catheter-Associated Urinary Tract Infection and Encrustation. ACS Biomaterials Science & Engineering, 10(2), 1162-1172.

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Furosemide Dissolution Optimization

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Furosemide (FUR, 330.74 g/mol, >98% purity, Sigma-Aldrich, St. Louis, USA) was used as a model drug from the BCS IV class possessing acidic chemical groups, and thus changing its solubility as a function of actual pH value.
Hydroxypropyl cellulose (HPC, Klucel EXF Pharm, Mw~80,000, Ashland, Covington, KY, USA) and poly(vinylpyrrolidone) (PVP, Kollidon 90 F, Mw ~1,000,000–1,500,000, BASF, Ludwigshafen, Germany) were chosen as polymers. For the dissolution of the drug, triethanolamine (TEA, Ph. Eur.8.0., Molar Chemicals, Budapest, Hungary) was used as surfactant or sodium hydroxide (NaOH, Ph.Eur.8.0., Molar Chemicals, Budapest, Hungary) aqueous solution of 2 M concentration was used as a pH modulator, and purified water was used as solvents of the polymers.

Kovács A., Kazsoki A., Démuth B., Szirányi B., Madarász J., Süvegh K, & Zelkó R. (2020). Influence of Aqueous Solubility-Enhancing Excipients on the Microstructural Characteristics of Furosemide-Loaded Electrospun Nanofibers. Pharmaceutics, 12(4), 385.

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Formulation and Characterization of BCS IV Drug

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Hydroxypropyl cellulose (Klucel EXF Pharm, Ashland, Covington, KY, USA; Mw ~ 80,000, the moles of substitution = 3.8), poly(vinylpyrrolidone) (Kollidon 90 F, BASF, Ludwigshafen, Germany; Mw ~ 1,000,000–1,500,000) as polymers (Figure 1b,c), trolamine (Ph. Eur., Molar Chemicals, Budapest, Hungary) as surfactant, and purified water was used as solvent for the polymers. Furosemide (Ph. Eur., Figure 1a) was used as model drug from the BCS IV class.

Kovács A., Démuth B., Meskó A, & Zelkó R. (2017). Preformulation Studies of Furosemide-Loaded Electrospun Nanofibrous Systems for Buccal Administration. Polymers, 9(12), 643.

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Formulation Development and Characterization

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The polymers Kollidon 90F (polyvinylpyrrolidone), Kollidon VA64 (vinylpyrrolidone-vinyl acetate copolymers), and Kollicoat SR 30D (polyvinyl acetate dispersion (aq)) were kindly provided by BASF (Ludwigshafen, Germany); Pemulen TR-2-NF (acrylates/C10–30 alkyl acrylate cross polymers) by Lubrizol (Leeds, UK); Eudragit RS PO (ammonio methacrylate copolymer type B) and Eudragit NM30 D (poly(ethyl acrylate-co-methyl methacrylate) (2:1)) by Evonik Industries (Darmstadt, Germany); and Klucel LF Pharm (hydroxypropyl cellulose) from Ashland (Schaffhausen, Switzerland). Four plasticisers with variable lipophilicity triethyl citrate (TEC) (log P = 0.12), tributyl citrate (TBC) (log P = 2.83), dibutyl sebacate (DBS) (log P = 4.87), and propylene glycol (PG) (log P = −0.47); solvents (ethanol, acetonitrile); PBS tablets; a model skin permeant hydrocortisone; the polyethersulfone Strat-M synthetic membrane (25 mm diameter); and additional chemicals such as ß-cyclodextrin were purchased from Merck Life Sciences (previously Sigma Aldrich, Dorset, UK).

Van Bocxlaer K., McArthur K.N., Harris A., Alavijeh M., Braillard S., Mowbray C.E, & Croft S.L. (2021). Film-Forming Systems for the Delivery of DNDI-0690 to Treat Cutaneous Leishmaniasis. Pharmaceutics, 13(4), 516.

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Polymer-based Drug Delivery System Formulation

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A high MW PLGA 50:50 grade Purasorb® PDLG 5010 (153 kg/mol) was obtained from Corbion (Purac Biomaterials, Gorinchem, Netherlands). High MW PVP (1,000,000-1,500,000) Kollidon® 90F was kindly donated by BASF (Germany). Ethanol, HPLC grades of water and acetonitrile (ACTN), PBS tablets with a pH 7.4, were all obtained from Sigma Aldrich Company Ltd (Sigma Aldrich, Dorset, UK). Pirfenidone was purchased from Tokyo Chemical Industry UK Ltd (The Magdalen Centre, Oxford, UK), while moxifloxacin hydrochloride was purchased from Cambridge Bioscience Ltd (Munro House, Cambridge, UK). Distilled water was generated by an ELGA Option 4 Water Purifier (Veolia Water Technologies, High Wycombe, UK).

Tawfik E.A., Craig D.Q.M, & Barker S.A. (2020). Dual drug-loaded coaxial nanofibers for the treatment of corneal abrasion. International journal of pharmaceutics, 581.

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Pregabalin Formulation and Evaluation

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Pregabalin was purchased from MSN Pharmachem (India). PEO (Polyox WSR 303) was purchased from Dow Chemical. Microcrystalline cellulose (MCC, Vivapur^® 12) was purchased from JRS Pharma (Germany), povidone (Kollidon^® 90F) from BASF (Germany), L-tartaric acid from Caviro (Italy), and D-mannitol from Roquette. All other excipients used were of pharmaceutical grade. All reagents used in the analyses were of analytical grade. An IR formulation (Lyrica Capsules, Pfizer) was used as a reference drug for pharmacokinetic studies.

Kim K.H., Lim S.H., Shim C.R., Park J., Song W.H., Kwon M.C., Lee J.H., Park J.S, & Choi H.G. (2020). Development of a Novel Controlled-Release Tablet of Pregabalin: Formulation Variation and Pharmacokinetics in Dogs and Humans. Drug Design, Development and Therapy, 14, 445-456.

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Formulation and Characterization of Ophthalmic Bevacizumab Hydrogel

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Polyacrylic acid, PAA (Carbopol ® 980, BF Goodrich Co., Holland); Polyvinyl alcohol, PVA (PolyViol ® 4-88, Merck, Germany); Hydroxypropylmethylcellulose, HPMC (Methocel ® K4M Premium EP, Colorcon, Italy); Polyvinylpyrrolidone, PVP (Kollidon ® 90F, Basf, Germany); Fluorescein isothiocyanate-dextran 150 kDa, FITC-DX (Sigma-Aldrich, Sweden); Bevacizumab, BVZ, commercial solution containing 25 mg/ml (Avastin ® , Roche, Swiss), trehalose (SG, Hayashibara Co., Japan), mannitol and lactose (EUPh grade, Carlo Erba, Italy). All other chemicals were of reagent grade.

Burgalassi S., Monti D., Nicosia N., Tampucci S., Terreni E., Vento A, & Chetoni P. (2018). Freeze-dried matrices for ocular administration of bevacizumab: a comparison between subconjunctival and intravitreal administration in rabbits. Drug delivery and translational research, 8(3).

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Optimizing Lipid-Lowering Drug Formulation

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Rosuvastatin calcium (RVT), Kollicoat® IR (KIR) and Kollidon® 90F (KF90) were purchased from BASF, Germany. Sodium dihydrogen phosphate, sodium phosphate dibasic dihydrate, methanol, sodium hydroxide were bought from Merck, Germany. Other chemical agents and distilled water were collected and prepared from the Biopharmaceutics laboratory, Department of Pharmaceutical Technology, University of Dhaka, Bangladesh.

Sikdar K.Y.K., Nazir M., Alam M.M., Sarkar M.R., & Rahman S.A.R. (2021). Evaluation of in vitro Dissolution Profile and Physicochemical Characterization of Polymer Based Formulations of Sparingly Soluble Rosuvastatin. Dhaka University Journal of Pharmaceutical Sciences, 20(2), 199-211.

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