4 nitrobenzyl bromide

Manufactured by Merck Group

Sourced in United States

4-nitrobenzyl bromide is a chemical compound used in various laboratory applications. It is a colorless, crystalline solid that is commonly utilized as a reagent or intermediate in organic synthesis reactions. The primary function of 4-nitrobenzyl bromide is to serve as a building block or precursor for the production of other chemical compounds. Its specific applications are determined by the intended use of the final product.

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3 protocols using 4 nitrobenzyl bromide

Synthesis of Zr-chelator Conjugates

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All solvents and reagents were purchased from commercial suppliers (Sigma Aldrich, St. Louis, MO; TCI America, Portland, OR; Fisher Scientific, Waltham, MA) and were used as received unless otherwise indicated. DMSO used for chelator stock solutions was of molecular biology grade (>99.9%: Sigma Aldrich). DFO.mesylate was purchased from Abcam. 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate (HATU) was purchased from AK Scientific. N,N-diisopropylethylamine (DIEA), diethyl malonate, 4-nitrobenzyl bromide, and borane-tetrahydrofuran solution (BH₃.THF) were purchased from Sigma-Aldrich. ZrCl₄, potassium carbonate anhydrous, and ammonium hydroxide were purchased from Fisher Scientific. All the chemicals were used directly without purification.

Sarbisheh E.K., Salih A.K., Raheem S.J., Lewis J.S, & Price E.W. (2020). DFO2: A High-Denticity Chelator for Enhanced Coordination of Zirconium-89. Inorganic chemistry, 59(16), 11715-11727.

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Sensitizing Chemicals Evaluation Protocol

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Sensitizing chemicals were benzylideneacetone (CAS 122-57-6, Sigma), oxazolone (15646-46-5, Sigma), 1,4-benzoquinone (CAS 106-51-4, Sigma), 2,4-dinitro chlorobenzene (CAS 97-00-7, Sigma), 4-nitrobenzylbromide (CAS 100-11-8, Sigma), glyoxal (CAS 107-22-2, Sigma), methyldibromoglutaronitrile (CAS 35691-65-7, Sigma), cinnamic aldehyde (CAS 104-55-2, SAFC), iso eugenol (CAS 97-54-1, Sigma), ethylene glycol dimethacrylate (CAS 97-90-5, Sigma), 2-mercaptobenzothiazole (CAS 149-30-4, Sigma), tetramethyl thiuram disulphide (CAS 137-26-8, Sigma), eugenol (CAS 97-53-0, Sigma), cinnamic alcohol (CAS 104-54-1, Sigma) and non-sensitizing substances include sodium dodecyl sulfate (CAS 151-21-3, Carl Roth), salicylic acid (CAS 69-72-7, Carl Roth), glycerol (CAS 56-81-5, Carl Roth), lactic acid (CAS 50-21-5, Carl Roth), methyl salicylate (CAS 119-36-8, Thermofisher), diethylphthalate (CAS 84-66-2, Thermofisher), sulphanilamide (CAS 64-74-1, Thermofisher), chlorobenzene (CAS 108-90-7, VWR) and isopropanol (67-63-0, CHEM-LAB).

Mertl E., Riegel E., Glück N., Ettenberger-Bornberg G., Lin G., Auer S., Haller M., Wlodarczyk A., Steurer C., Kirchnawy C, & Czerny T. (2019). A dual luciferase assay for evaluation of skin sensitizing potential of medical devices. Molecular biology reports, 46(5).

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Evaluating Chemical Sensitizers for Skin Allergy

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Table 1 summarizes the test chemicals used in this study. Benzaldehyde (BA), 1-bromobutane (BB), chlorobenzene (CB), 2,4-dinitrochlorobenzene (DNCB), Nacetylcysteine (NAC), nickel sulfate (Ni), 4-nitrobenzyl bromide (NB), salicylic acid (SA), lipopolysaccharide (LPS), monosodium urate crystal (MSU), and globulin Cohn fraction II, III human were purchased from Sigma-Aldrich Co. (St. Louis, MO, USA). Diethyl phthalate (DP), octanoic acid (OA), hydrogen peroxide (H 2 O 2 ), dimethyl sulfoxide (DMSO), potassium chloride (KCl), phosphate-buffered saline (PBS), and protease-free bovine serum albumin (BSA) were purchased from Wako Pure Chemical Industries Ltd. Physiological saline was purchased from Otsuka Pharmaceutical Co. Ltd. (Tokyo, Japan). FITC-conjugated anti-CD86 antibody (isotype: Gerberick et al. (2005) and the CD86/ CD54 data are based on Ashikaga et al. (2010) , Takenouchi et al. (2013) .
IgG1κ) (BD Bioscience, Franklin Lakes, NJ, USA), FITC-conjugated anti-CD54 antibody (DAKO, Glostrup, Denmark), and isotype control antibody (Mouse IgG1) (DAKO) were used for protein expression analysis. Propidium iodide (PI, 1 mg/mL) was purchased from Dojindo Laboratories, Kumamoto, Japan.

Mitachi T., Kouzui M., Maruyama R., Yamashita K., Ogata S., Kojima H, & Itagaki H. (2019). Some non-sensitizers upregulate CD54 expression by activation of the NLRP3 inflammasome in THP-1 cells. The Journal of toxicological sciences, 44(3).

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