Au640

Manufactured by Beckman Coulter

Sourced in United States, Portugal

The AU640 is a chemistry analyzer from Beckman Coulter designed for clinical laboratory use. It is capable of performing a wide range of routine and specialized clinical chemistry tests. The core function of the AU640 is to analyze patient samples and provide accurate and reliable results to support clinical decision-making.

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Lab products found in correlation

Au2700, by Beckman Coulter (2 mentions) Au400, by Beckman Coulter (1 mentions) Automatic haematology analyser, by Sysmex (1 mentions) Modular p, by Roche (1 mentions)

7 protocols using au640

Urine Protein, SDMA, and Creatinine Analysis

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UPC was measured on the day of diagnosis on urine samples with inactive sediment. Urine samples collected by free catch or cystocentesis were centrifuged and urinary protein was measured using pyrogallol red combined with molybdate (Beckman Coulter AU400) and urinary creatinine using the Jaffé method (Beckman Coulter AU400). Dogs were considered proteinuric when UPC was >0.5.
Banked serum samples were thawed and sent under refrigeration to IDEXX Laboratories (Spain) for measurement of SDMA and creatinine concentrations. SDMA concentration was measured using the IDEXX SDMA Test (Beckman Coulter AU640) which is based on a previously validated [24 ] immunoassay using a glucose-6-phosphate dehydrogenase conjugate and an anti-SDMA monoclonal antibody [28 ]. Creatinine concentration was measured using the Jaffé method [29 (link)] (Beckman Coulter AU640). Creatinine concentrations ≥ 1.4 mg/dL were considered increased according to the IRIS and LeishVet classifications. Based on IDEXX Laboratories algorithm for interpreting one-single-point SDMA measurements [30 ], a medical decision cut-off point of >19 μg/dL was used to define increased concentrations of SDMA.

Torrent E., Planellas M., Ordeix L., Pastor J., Rodon J, & Solano-Gallego L. (2018). Serum Symmetric Dimethylarginine as an Early Marker of Excretory Dysfunction in Canine Leishmaniosis (L. infantum) Induced Nephropathy. Veterinary Medicine International, 2018, 7517359.

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Comprehensive Biochemical Profiling in CAG

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The serum IgM levels of all patients were measured before their CAG using an IgM assay kit (batch number: YZB/USA 4923-2014) on a Beckman Coulter AU640 automatic biochemical analyser. Serum concentrations of total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), fasting blood glucose (FBG), creatinine (Crea), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total protein (TP) and albumin (ALB) were measured using assay kits from Sekisui Medical Technologies (Osaka, Japan) on a Hitachi 7180 chemistry analyser. Routine blood indices were tested using an automatic haematology analyser (Sysmex, Kobe, Japan). There is no missing data in our study.

Zhang Y., Qi X., Wang S., Zhang W., Yang R., Wang X., Chen W., Ji F., Dong J, & Yu X. (2024). Serum immunoglobulin M is associated with the severity of coronary artery disease in adults. PeerJ, 12, e17012.

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PFOA Serum Levels in High Fat Diet Hamsters

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Clinical observations were conducted daily and body weights were determined weekly on all hamsters. Food consumption was measured weekly. Serum lipid concentrations (triglycerides, cholesterol-total, and HDL) were measured following 1, 10, 20, and 30 daily doses of APFO. These lipid parameters were determined using standard reagents on an Olympus^® AU640 (Beckman Coulter) clinical chemistry analyzer (Irving, TX). Serum PFOA concentrations were analyzed at the same intervals using the analytical methods described earlier. The primary outcome tested was the serum PFOA concentration at several time points as a function of being fed either a high fat content or a normal rodent diet.

Everds N.E, & Kennedy G.L. (2015). Serum perfluorooctanoic acid (PFOA) concentrations in normal and hyperlipidemic female hamsters dosed orally with ammonium perfluorooctanoate (APFO) for up to 30 days. Toxicology Reports, 2, 70-77.

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Glucose and C-peptide Response during OGTT

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Plasma glucose, insulin and C-peptide levels were measured at baseline, and after 30 and 120 min of OGTT. Glucose levels were measured using a glucose analyser (Olympus AU640, Beckman Coulter, Portugal). Insulin and C-peptide levels were determined using Liaison chemiluminescence assays (DiaSorin, Italy). NGT and prediabetic individuals were compared using the Mann–Whitney test in GraphPad Prism 8, Version 8.2.1 (279) (USA). The HOMA-IR was assessed [32 (link)]. Glucose and C-peptide AUCs during the OGTT were calculated according to the trapezoid method:

\begin{array}{l} Glucose AUC = \frac{Glucose 0 min + Glucose 30 min}{2} \times 30 + \frac{Glucose 30 min + Glucose 120 min}{2} \times 90 \\ C - peptide (AUC 0 - 120 min) = \frac{C - peptide 0 min + C - peptide 120 min}{2} \times 120 \end{array}

Patarrão R.S., Duarte N., Coelho I., Ward J., Ribeiro R.T., Meneses M.J., Andrade R., Costa J., Correia I., Boavida J.M., Duarte R., Gardete-Correia L., Medina J.L., Pell J., Petrie J., Raposo J.F., Macedo M.P, & Penha-Gonçalves C. (2022). Prediabetes blunts DPP4 genetic control of postprandial glycaemia and insulin secretion. Diabetologia, 65(5), 861-871.

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Fructosamine and HbA1c Measurements in Diabetes

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A total of 126 fructosamine values were measured as part of routine clinical care on the same day as or within 30 days of HbA1c values using a colorimetric assay (Beckman Coulter AU640). We measured fructosamine from an additional 219 frozen serum samples drawn within 30 days of an HbA1c value to ensure a broad range of clinical characteristics and diabetes status. While HbA1c and fructosamine values could differ by as many as 30 days, the median difference between fructosamine and HbA1c values was 0 days, interquartile range 0 to 0 days. The quantitative determination of fructosamine on human serum was performed on a Roche automated clinical chemistry analyzer (Modular P). This colorimetric assay is based on the ability of ketoamines to reduce nitrotetrazolium blue (NBT) to formazan in an alkaline solution. The rate of formation of formazan is directly proportional to the concentration of fructosamine. A reference range of 205 to 285 μmol/L is considered to be normal with values above 285 μmol/L elevated.

Duran L., Rodriguez C., Drozd D., Nance R.M., Delaney J.A., Burkholder G., Mugavero M.J., Willig J.H., Warriner A.H., Crane P.K., Atkinson B.E., Harrington R.D., Dhanireddy S., Saag M.S., Kitahata M.M, & Crane H.M. (2015). Fructosamine and Hemoglobin A1c Correlations in HIV-Infected Adults in Routine Clinical Care: Impact of Anemia and Albumin Levels. AIDS Research and Treatment, 2015, 478750.

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Neonatal Serum Creatinine Measurement

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All s[Cr]s obtained during the normal course of care during the first 60 d of age were included in the analyses. S[Cr] was measured using a kinetic modification of the Jaffe method on AU 2700 and AU 640 analyzers (Beckman Coulter, Brea, CA). The method of analysis remained unchanged during the study period. The results conformed to standard values generated by isotope dilution mass spectrometry (29 (link)). The manufacturer reports no significant interference (within 10% of initial value) for serum bilirubin levels up to 342 µmol/l (Creatinine, General Chemistry OSR BAOSR6 × 78.02, Beckman Coulter).

Bateman D.A., Thomas W., Parravicini E., Polesana E., Locatelli C, & Lorenz J.M. (2015). Serum creatinine concentration in very-low-birth-weight infants from birth to 34–36 wk postmenstrual age. Pediatric Research, 77(5), 696-702.

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Urinary NGAL Biomarker Monitoring

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Bagged spot urine samples were collected on the day of enrolment (usually in the first week of life), and daily until 32 wk postmenstrual age, discharge or death, whichever occurred first. The urine was centrifuged within 24 h of collection and the supernatant stored at -80°C. NGAL concentration was determined by immunoblot as previously described (15) . UNGAL analysis occurred after infants had been discharged. All s[Cr]s obtained during the normal course of care during the study period were included in the analyses. Then, s[Cr] was obtained on the same day of the urine collection by 95% of the time. It was measured using a kinetic modification of the Jaffe method on Beckman Coulter AU 2700 and AU 640 analyzers (Beckman Coulter, Brea, CA). The method of analysis remained unchanged during the study period. Results conformed to standard values generated by isotope dilution mass spectrometry (29) . Manufacturer reports no significant interference (within 10% of initial value) for serum bilirubin levels up to 20 mg/dl (30) .

Parravicini E., Locatelli C., Lorenz J.M., Nemerofsky S.L, & Bateman D.A. (2016). Is urinary neutrophil gelatinase-associated lipocalin able to predict acute kidney injury episodes in very low birth weight infants in clinical settings?. Pediatric research, 80(5).

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