Invivoscope software

Manufactured by Invicro

Sourced in United States

InVivoScope software is a versatile image processing and visualization tool for preclinical imaging data. It provides a platform for managing, analyzing, and sharing imaging data from various preclinical imaging modalities.

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Lab products found in correlation

Minerve, by Bioscan (1 mentions) Vivoquant 4, by Invicro (1 mentions) Nanospect ct, by Mediso (1 mentions)

3 protocols using invivoscope software

Preclinical FDG-PET Imaging of Orthotopic Tumors

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FDG-PET scanning was performed to detect orthotopic tumours. The 18 (link)F-FDG was produced and provided by Skåne University Hospital Cyclotron Unit. For PET-imaging, mice were intravenously injected with approximately 30 MBq of FDG and were imaged 1 h after administration using a preclinical PET/CT-scanner (Bioscan, USA). Mice were anaesthetised using 2–3% isofluorane and were placed in a temperature regulated animal chamber (Minerve, Bioscan, USA) with the temperature set to 37°C (Minerve multistation controller unit) during the scanning. During the acquisitions, respiration was monitored on PC (SA Instruments, Inc, USA) and anaesthesia levels were adjusted accordingly. CT scanning was performed using the X-ray exposure of 600 ms and 177 μA, and the zoom level set to medium zoom. The CT images were scanned with 180 projections/rotation, pitch 1.0 and a binning of 1:4. The CT reconstruction was performed utilizing a Butterworth filter algorithm. The PET acquisition was performed with the coincidence mode set 1-3. The PET data was acquired in list mode for 30 minutes, and reconstructed dynamically using the OSEM option and rebinning SSRB to 2D LOR with the ring difference set to 8. CT and PET images were evaluated and created using the InVivoScope software (InviCRO).

Braekeveldt N., Wigerup C., Gisselsson D., Mohlin S., Merselius M., Beckman S., Jonson T., Börjesson A., Backman T., Tadeo I., Berbegall A.P., Öra I., Navarro S., Noguera R., Påhlman S, & Bexell D. (2014). Neuroblastoma patient-derived orthotopic xenografts retain metastatic patterns and geno- and phenotypes of patient tumours. International Journal of Cancer. Journal International du Cancer, 136(5), E252-E261.

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Quantifying Vascular Tracer Uptake in Mice

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The scans were reconstructed and processed using InVivoScope software (Invicro, Boston, MA, USA). Tracer uptake identified as focal areas of activity in the ascending aorta, arch, and brachiocephalic trunk were identified on transverse sections by triangulating from coronal and/or sagittal images and using contrast in the vessels on the CTA for anatomical localization. Regions of interest (ROIs) were drawn around all these areas of focal activity and counts in the ROIs converted to mCi using a calibration algorithm and activity for all regions summed for the total vascular tracer uptake (Figure 1). The summed activity from the ascending aorta and arch (excluding the brachiocephalic vessels) was correlated with ex vivo gamma counting of the same tissue. To address whether there were differences in blood pool activity between the diabetic and non-diabetic mice at the time of imaging, ROIs were drawn in the center of the mid-LV cavity on the transverse slice to measure activity (in mCi/mm³).Figure 1

Method for ROI placement for quantification. Slices comprising the focal uptake (red color table) are identified on the coronal projection, and an ROI is drawn around the uptake on the transverse projection. The counts in this region are converted to mCi using a calibration standard that is loaded into the software.

Tekabe Y., Kollaros M., Zerihoun A., Zhang G., Backer M.V., Backer J.M, & Johnson L.L. (2014). Imaging VEGF receptor expression to identify accelerated atherosclerosis. EJNMMI Research, 4, 41.

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In Vivo Biodistribution of Radioisotope-Labeled NM-scFv

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The ¹¹¹In-labeled NM-scFv was IV injected into three mice at a dose of 152.5 µg of siRNA per kg of mouse at 3.7 ± 0.74 MBq of radioactivity. At 40 min post-injection, the mice were sacrificed and SPECT-CT images were acquired with a NanoSPECT/CT (Mediso, Budapest, Hungary). Helical SPECT scans with 24 projections of 60 s were acquired before the CT scans with the following parameters: exposure time at 500 m, 55 KVp, 145 µA, 180 projections and pitch set to 1. The reconstruction of SPECT images was performed on the HiSPECT NG software (Scivis GmbH, Göttingen, Germany) and that of CT images was achieved on InVivoScope software (Invicro, Boston, MA, USA). The accumulation of radioactivity in major organs was also quantified using VivoQuant 4.0 (Invicro, Boston, MA, USA) thanks to a mouse phantom filled with known ¹¹¹In activity. The final results were presented as mean values ± standard deviation.

Nguyen P.V., Allard-Vannier E., Aubrey N., Labrugère-Sarroste C., Chourpa I., Sobilo J., Le Pape A, & Hervé-Aubert K. (2022). Radiolabeling, Quality Control and In Vivo Imaging of Multimodal Targeted Nanomedicines. Pharmaceutics, 14(12), 2679.

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