Balb cannrj foxn1nu nu

Manufactured by Janvier Labs

The BALB/cAnNRj-Foxn1nu/nu is a laboratory mouse strain. The strain is homozygous for the Foxn1nu mutation, which results in a T-cell deficient, athymic phenotype.

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Balb cjrj, by Janvier Labs (1 mentions) Nod cg prkdcscid il2rgtm1wjl szj mice, by Jackson ImmunoResearch (1 mentions)

3 protocols using balb cannrj foxn1nu nu

Dynamic PET/CT Imaging in Nude Mice

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Briefly, 4–5-week-old male nude mice (Balb/cAnNRj-Foxn1^nu/nu) were obtained from Janvier. A dynamic PET scan over 90 min and a subsequent CT image over 20 min were acquired using a triple-modality Bruker Albira II small-animal PET/CT/SPECT scanner. Three animals were studied per group.

Cheng X., Hübner R., von Kiedrowski V., Fricker G., Schirrmacher R., Wängler C, & Wängler B. (2021). Design, Synthesis, In Vitro and In Vivo Evaluation of Heterobivalent SiFAlin-Modified Peptidic Radioligands Targeting Both Integrin αvβ3 and the MC1 Receptor—Suitable for the Specific Visualization of Melanomas?. Pharmaceuticals, 14(6), 547.

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Mouse Models for Immunological Research

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BALB/cJRj and BALB/cAnNRj-Foxn1^nu/nu were purchased from Janvier labs (Roubaix, FR). NOD.Cg-Prkdc^scidIl2rg^tm1Wjl/SzJ mice were originally obtained from the Jackson Laboratory and provided by Christian Münz (University of Zurich, Switzerland). Mice were kept under specific pathogen-free conditions in individually ventilated cages at the Laboratory Animal Services Center at the University of Zurich. Mice had access to food and water ad libitum and were maintained on a 12-h light/dark cycle with environmental enrichment. All experiments were performed with 8–14-weeks-old female mice in accordance with the Swiss federal and cantonal regulations on animal protection and were approved by The Cantonal Veterinary Office Zurich (156/2018).

Tallón de Lara P., Castañón H., Vermeer M., Núñez N., Silina K., Sobottka B., Urdinez J., Cecconi V., Yagita H., Movahedian Attar F., Hiltbrunner S., Glarner I., Moch H., Tugues S., Becher B, & van den Broek M. (2021). CD39+PD-1+CD8+ T cells mediate metastatic dormancy in breast cancer. Nature Communications, 12, 769.

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Establishing Orthotopic PDX Mouse Models

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Orthotopic PDX mouse models were established in 6–10-week-old female immunocompromised mice (NSG, NOD.Cg-Prkdc^scidIl2rg^tm1Wjl). For the pilot radiation study, patient-derived cells were injected in mice of NOD.Cg-Prkdc^scidIl2rg^tm1Wjl (NSG, DKFZ breeding), NOD.Cg-Rag1^tm1MomIl2rg^tm1Wjl (NRGS, DKFZ breeding) and BALB/cAnNRj-Foxn1^nu/nu (BALB/c, Janvier). For all other experiments with PDX models, 6–10-week-old female NRGS mice were used. Patient-derived tumor cells were injected into the cerebellum, as described previously.^{34 (link)} Tumor growth was followed by MRI and animals were randomized into treatment groups based on tumor volume measurements. For radiation experiments with Trp53^+/− mice, 6–10-week-old male and female mice from the 129-Trp53tm1Tyj strain were used. All animal experiments were performed in accordance with ethical and legal regulations for animal welfare and approved by the governmental council (Regierungspräsidium Karlsruhe, Germany).

Simovic M., Bolkestein M., Moustafa M., Wong J.K., Körber V., Benedetto S., Khalid U., Schreiber H.S., Jugold M., Korshunov A., Hübschmann D., Mack N., Brons S., Wei P.C., Breckwoldt M.O., Heiland S., Bendszus M., Debus J., Höfer T., Zapatka M., Kool M., Pfister S.M., Abdollahi A, & Ernst A. (2021). Carbon ion radiotherapy eradicates medulloblastomas with chromothripsis in an orthotopic Li-Fraumeni patient-derived mouse model. Neuro-Oncology, 23(12), 2028-2041.

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