An AFM (Solver PRO, NT MDT, Moscow, Russia) was used to characterize the surface topography of the samples. All measurements were done under semi contact mode using golden silicon probes NSG10 tips (NT MDT, Limerick, Ireland) with a resonance frequency of 140–390 kHz and a force constant of 3.1–37.6 N/m.
Nsg10 tips
Manufactured by NT-MDT
Sourced in Ireland
The NSG10 tips are a type of scanning probe microscope (SPM) probe designed for use with NT-MDT's instrumentation. The tips are crafted from silicon and feature a sharp apex, optimized for high-resolution imaging and nanoscale analysis. The core function of the NSG10 tips is to provide a durable and reliable probe for SPM measurements, supporting the overall capabilities of the NT-MDT product line.
Automatically generated - may contain errors
2 protocols using nsg10 tips
1
Atomic Force Microscopy of Samples
2
Characterization of Nanomedicine Microcapsules
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The measurements of ζ -potential and size distribution of nanoparticles were performed using a Zetasizer Nano ZS instrument (Malvern Instruments Ltd., UK).
Atomic Force Microscopy (AFM) images were taken by using a NT-MDT Ntegra Spectra instrument operating in the tapping mode with NSG-10 tips from NT-MDT (Russia). TEM imaging was performed using a Zeiss EM 912 Omega (Zeiss, Germany) transmission electron microscope.
The thickness of the microcapsule shell is a half of double the shell thickness. The double shell thickness was measured by AFM method using the flat regions of the microcapsule shell profile by approach described in ref 47 .
MRI was performed using a Philips Achieva 1.5T high field MRI scanner equipped with a phased array coil. T2-and T1-weighted quick "spin-echo" protocols (turbospinecho, TSE) were applied. Measurements were carried out with following parameters: the repetition time (TR) is 450 ms and the echo time (TE) is 15 ms for T1-weighted pulse sequence; the TR is 3000 ms, the TE is 47.7 ms for T2-weighted pulse sequence.
Decreasing of T1 relaxation time leads to increasing of MR signal in T1-weighted images. At the same time decreasing of T2 relaxation time falls to MR signal in T2-weighted images. 48
Atomic Force Microscopy (AFM) images were taken by using a NT-MDT Ntegra Spectra instrument operating in the tapping mode with NSG-10 tips from NT-MDT (Russia). TEM imaging was performed using a Zeiss EM 912 Omega (Zeiss, Germany) transmission electron microscope.
The thickness of the microcapsule shell is a half of double the shell thickness. The double shell thickness was measured by AFM method using the flat regions of the microcapsule shell profile by approach described in ref 47 .
MRI was performed using a Philips Achieva 1.5T high field MRI scanner equipped with a phased array coil. T2-and T1-weighted quick "spin-echo" protocols (turbospinecho, TSE) were applied. Measurements were carried out with following parameters: the repetition time (TR) is 450 ms and the echo time (TE) is 15 ms for T1-weighted pulse sequence; the TR is 3000 ms, the TE is 47.7 ms for T2-weighted pulse sequence.
Decreasing of T1 relaxation time leads to increasing of MR signal in T1-weighted images. At the same time decreasing of T2 relaxation time falls to MR signal in T2-weighted images. 48
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