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Advance tomograph

Manufactured by GE Healthcare
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The Advance tomograph is a diagnostic imaging system designed for medical professionals. It is capable of generating high-quality, detailed images of the human body to aid in clinical analysis and decision-making. The core function of the Advance tomograph is to acquire and process tomographic data, which can be used to visualize the internal structures of the body.

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Lab products found in correlation

Biograph mct pet ct scanner, by Siemens (1 mentions) Ecat high resolution research tomograph hrrt, by Siemens (1 mentions) Matlab 7, by MathWorks (1 mentions) Biograph 64 pet ct, by Siemens (1 mentions)

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GE Advance tomograph

5 protocols using advance tomograph

1

FDG-PET Brain Imaging Protocols

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2-[18F]FDG PET brain images of patients and NC in identification and internal validation groups were acquired at the Department of Nuclear Medicine, UMCL with Siemens Biograph mCT PET/CT scanner according to clinical diagnostic protocol5 (link) as described previously27 (link). Patients from ADNI cohort underwent imaging using different scanners at different sites as per study protocol, described in more detail at: https://adni.loni.usc.edu/methods/pet-analysis-method/pet-analysis/. 2-[18F]FDG PET brain images of patients and NC from North Shore University Hospital were acquired with GE Advance tomograph at The Feinstein Institutes for Medical Research as described previously12 (link).
Perovnik M., Tomše P., Jamšek J., Emeršič A., Tang C., Eidelberg D, & Trošt M. (2022). Identification and validation of Alzheimer’s disease-related metabolic brain pattern in biomarker confirmed Alzheimer’s dementia patients. Scientific Reports, 12, 11752.
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2

Multimodal PET Imaging of Neurotransmitter Systems

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Imaging was carried out using 18F-6-fluoro-L-dopa (FDOPA, a measure of dopamine synthesis and storage), (+)-11C-dihydrotetrabenazine (DTBZ, marker for the vesicular monoamine transporter type 2), and 11C-raclopride (RAC, marker of dopamine D2/D3 receptors), and 11C-3-amino-4-(2-dimethylaminomethyl-phenylsulfanyl)-benzonitrile (DASB, marker of the serotonin transporter). Imaging with dopaminergic tracers was performed on the GE Advance tomograph (4.2 mm resolution FWHM), while DASB scanning took place on the Siemens ECAT high resolution research tomograph (HRRT, 2.3 mm resolution FWHM). Emission data were collected for 60 (DTBZ, RAC), 90 (FDOPA), or 100 minutes (DASB) following bolus injection of the PET tracer. This study was approved by the University of British Columbia Ethics Committee.
Felicio A.C., Dinelle K., Agarwal P.A., McKenzie J., Heffernan N., Road J.D., Appel-Cresswell S., Wszolek Z.K., Farrer M.J., Schulzer M., Sossi V, & Stoessl A.J. (2014). In vivo dopaminergic and serotonergic dysfunction in DCTN1 gene mutation carriers. Movement disorders : official journal of the Movement Disorder Society, 29(9), 1197-1201.
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GE Advance Tomograph Imaging

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All imaging were performed on a GE Advance tomograph (Waukesah, WI, USA).
Seenu V., Sharma A., Kumar R., Suhani S., Prashanth A., Mathur S, & Parshad R. (2020). Evaluation of estrogen expression of breast cancer using 18F-FES PET CT-A novel technique. World Journal of Nuclear Medicine, 19(3), 233-239.
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Resting-State 18F-FDG PET Imaging

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All subjects were asked to fast for at least 6 h but had free access to water, and antiparkinsonian medications in patients were withheld for at least 12 h before PET imaging. The USA site used a GE Advance tomograph (Milwaukee, WI). A PET transmission scan was first performed for attenuation correction with a 10-min emission scan acquired in 3D mode between 35 and 45 min after intravenous bolus injection of 18F-FDG (~185 MBq). The Chinese site used a Siemens Biograph 64 PET/CT (Munich, Germany). Following a short CT scan, a 10-min PET scan was started 45-min post-injection. Only relative glucose metabolic activity was measured as no arterial blood sampling was taken in this clinical imaging protocol. All studies in patients and NL controls were performed in a resting state in a quiet and dimly lit room.
Images were processed by Statistical Parametric Mapping (SPM5) software (Wellcome Department of Imaging Neurosciences, Institute of Neurology, London, UK) implemented in Matlab 7.4.0 (Mathworks Inc, Sherborn, MA). All scans were spatially normalized into a standard brain space and smoothened by a Gaussian filter of 10-mm FWHM over a 3D space to increase the signal to noise ratio for statistical analysis.
Shen B., Wei S., Ge J., Peng S., Liu F., Li L., Guo S., Wu P., Zuo C., Eidelberg D., Wang J, & Ma Y. (2020). Reproducible metabolic topographies associated with multiple system atrophy: Network and regional analyses in Chinese and American patient cohorts. NeuroImage : Clinical, 28, 102416.
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5

PET Imaging of Parkinson's Subjects

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All subjects were scanned using the General Electric Advance tomograph (Milwaukee, WI) at the Feinstein Institutes/Northwell Health as described previously [20 (link)]. In brief, all subjects fasted overnight and antiparkinsonian medication was withheld at least 12 hours before the scan. Scans from each subject were realigned and spatially normalized to a standard Montreal Neurological Institute (MNI)-based PET brain template and smoothed with an isotropic Gaussian kernel (10 mm) in all directions to improve the signal-to-noise ratio. Image processing was performed using Statistical Parametric Mapping (SPM5) software (Wellcome Centre for Human Neuroimaging, London, UK).
Schindlbeck K.A., Gupta D.K., Tang C.C., O'Shea S.A., Poston K.L., Choi Y.Y., Dhawan V., Vonsattel J.P., Fahn S, & Eidelberg D. (2021). Neuropathological correlation supports automated image-based differential diagnosis in parkinsonism. European journal of nuclear medicine and molecular imaging, 48(11), 3522-3529.
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