Talinolol (purity > 99.2%) was purchased from Alfa Aesar (Ward Hill, MA, United States). Miglyol 812 (medium chain triglyceride, M812), Imwitor 988 (medium chain mono- and di-glycerides, I988), Imwitor 308 (medium chain monoglycerides, I308) were kindly supplied by Sasol Germany GmbH (Werk, Witten, Germany). HCO-30 (hydrogenated castor oil, HLB = 11) and POE-6-sorbitan monooleate (TO-106V, HLB = 10.5) were obtained from Nikko Chemicals (Tokyo, Japan). Capmul MCM (CMCM) was obtained from Abitec Corporation, Janesville, WI, United States, Coconut oil fatty acid (COFA). Softigen 767 (S767) was purchased from Cremer oleo GmbH & Co. (Hamburg, Germany). Phosal 25 MCT (P25MCT) was obtained from Lipoid GmbH (Steinhausen, Switzerland). Transcutol (TC) was kindly supplied by Gattefossé (Lyon, France). Talinolol commercial tablets (Cordanum® 50 mg) were a gift from AWD, pharma GmbH & Co., KG (Dresden, Germany). Capsule of plant origin with a size of (00) were obtained from Qualicaps, Co., Ltd. (Japan). Simulated intestinal fluid (SIF) powder (bile salt/phospholipid) was purchased from Biorelevant.com, Ltd., London, United Kingdom. Porcine pancreatin (8_USP specifications activity) was purchased from Sigma Chemical, Co., St. Louis, MO, United States. Milli-Q grade water was obtained from a Milli-Q Integral Water Purification System (Millipore, Bedford, MA, United States).
Imwitor 988
Manufactured by Sasol
Sourced in Germany
Imwitor 988 is a lipid-based excipient used in the formulation of pharmaceutical and cosmetic products. It is a mixture of mono- and diglycerides of fatty acids. Imwitor 988 serves as an emulsifier, stabilizer, and lubricant in various applications.
Automatically generated - may contain errors
Lab products found in correlation
Milli q integral water purification system, by Merck Group (2 mentions)
Cremophor rh40, by BASF (2 mentions)
Porcine pancreatin 8 usp specifications activity, by Merck Group (1 mentions)
Miglyol 812, by Sasol (1 mentions)
Imwitor 308, by Sasol (1 mentions)
Transcutol, by Gattefosse (1 mentions)
Piperine, by Merck Group (1 mentions)
Integral water purification system, by Merck Group (1 mentions)
Milli q water, by Merck Group (1 mentions)
Miglyol 812n, by Sasol (1 mentions)
Solutol hs 15, by BASF (1 mentions)
4 protocols using imwitor 988
1
Talinolol Formulation Development and Evaluation
2
Ramipril Nanoemulsion Formulation Development
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Ramipril (RMP) was donated by Zydus Cadila Healthcare Ltd. (Ahmedabad, Gujrat, India). Cremercoor® MCT 70/30 (MCT, Caprylic/capric acid medium chain triglycerides, 70% caprylic C8, 30% capric C10) was gratuitously provided by Cremer Oleo GmbH & Co. KG (Hamburg, Germany). Imwitor 988 (I988, Mixture of medium chain mono and diglycerides) was purchased from Sasol, GmbH (Werk Witten, Witten, Germany). Capmul MCM (CMCM, medium chain mono diglycerides c8-10) was donated by Abitec Corporation (Germany). The non-ionic surfactants TO106V (PEG-6 sorbitan oleate water-insoluble, HLB=10) and HCO-30 (Polyoxyethylene hydrogenated castor oil, HLB=11) were donated by Nikko Chemicals Co. (Tokyo, Japan). The co-solvent Transcutol® (TC, highly purified diethylene glycol monoethyl ether) was donated by Gattefossé (Lyon, France). Syloid® (SYL) was gratuitously provided by Grace Gmbh & Co. KG (Worms, Germany). The high purity Milli-Q water was obtained through a Milli-Q Integral Water Purification System (Millipore, Bedford, MA). The Ramipril Sandoz® 2.5 mg tablet was used as a marketed drug. All other reagents were of analytical grade and used without further purification.
3
Formulation and Characterization of Curcumin-Piperine Loaded Nanoemulsions
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Curcumin (CUR, purity = 99.5%) was supplied by Enzo Life Sciences (Lausen, Switzerland). Piperine (PP, purity = 99.8%) was obtained from Sigma Aldrich (MO, USA). Imwitor 988 (I988, medium-chain mono and diglycerides) and non-ionic surfactant Tween 85 (T85) were obtained from Sasol, GmbH (Werk Witten, Witten, Germany). Cremophor RH40 (Polyoxyl 40 Hydrogenated Castor Oil, CrRH40) was supplied by BASF (Ludwigshafen, Germany). Transcutol P (TcP) was generously supplied by Gattefossé (Saint priest, France). BSO was obtained from the seeds of Nigella sativa (N. sativa) Linn. (black seeds), family Ranunculaceae and Zanthoxylum rhetsa seed oil (ZRO) obtained from dried fruits of Roxb DC plant that belongs to the family Rutaceae by the cold press/steam distillation method. Both BSO and ZRO were collected from Kaligonj, Gazipur, Bangladesh. Highly purified Milli-Q water was used from a Milli-Q Integral Water Purification System (Millipore, Bedford, MA). All other chemicals and reagents used in the studies were analytically pure.
4
Formulation and Characterization of Glipizide Loaded Lipid-Based Delivery Systems
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Pharmaceutical grade of glipizide was a generous gift from Alembic Ltd., Vadodara, India. Abitec Corp., Janesville, USA, supplied EP/NF grade of medium chain tri-glycerides (Captex® 300, and Captex® 355) and medium chain mono-glycerides (Capmul® MCM,). EP grades of poly-glycol mono and di-esters of 12-hydroxy stearic acid (Solutol® HS15) and polyethylene glycol-40 hydrogenated castor oil (Cremophor® RH40); provided by BASF SE, Ludwigshafen, Germany. EP grade of medium chain tri-glycerides (Labrafac lipophile™ WL 1349, Labrafac™ PG) and PEG-8 glyceryl caprylate (Labrasol®) were supplied by Gattefosse Corp., Saint-Priest, France. EP grades of medium chain tri-glycerides (Miglyol® 812 N) and medium chain mono-glycerides (Imwitor® 988) were supplied by Sasol, GmbH Germany. Tween® 80, Coconut oil, Castor oil, Olive oil, and Polyethylene glycol 400 (PEG 400) were purchased from Himedia Lab. Private Ltd., Mumbai, India. Capsugel Health Care Ltd., Mumbai, India, supplied size “1” hard gelatin capsule shell. 18 MΩ Water (HPLC grade) obtained in-house from a Direct Q-3 UV water purification system (Millipore India Pvt. Ltd., Bengaluru, India).
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