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N boc ethanolamine

Manufactured by Merck Group
Sourced in China

N-Boc-ethanolamine is a chemical compound used as a building block in organic synthesis. It is a protected amino alcohol with a tert-butyloxycarbonyl (Boc) protecting group. The compound is commonly used as a versatile intermediate in the preparation of various pharmaceutical and other chemical products.

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3 protocols using n boc ethanolamine

1

Hyaluronic Acid-based Nanoparticles for Doxorubicin Delivery

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Hyaluronic acid, propylene sulfide, adipic
dihydrazide, caprolactone, N-Boc-ethanolamine, doxorubicin
hydrochloride (DOX·HCl), dicyclohexylcarbodiimide (DCC), 4-dimethylaminopyridine
(DMAP), ethyl-3-(3-dimethylaminopropyl) carbodiimidehydrochloride
(EDC·HCl), and N-hydroxysuccinimide (NHS) were
purchased from Sigma-Aldrich Co., Ltd. (Beijing, China). N,N-Dimethylformamide (DMF) and triethylamine (TEA)
were purchased from Alfa Aesar Co., Ltd. (Shanghai, China). 2,7-Dichlorofluorescin
diacetate (DCFH-DA) was purchased from Yeasen Biotechnology Co., Ltd.
(Shanghai, China). 4′,6-Diamidino-2-phenylindole (DAPI), propidium
iodide (PI), 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium
bromide (MTT), and TUNEL agents were obtained from Solarbio Co., Ltd.
(Beijing, China). Cell culture agents were purchased from GIBCO. Antibodies
were acquired from Abcam Co., Ltd. (Shanghai, China).
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2

Synthesis and Characterization of Oxonorbornene Monomers

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Reagent-grade maleic acid anhydride, furan, 1-butanol, 4-(dimethylamino)pyridine, dicyclohexyl carbodiimide, and N-Boc-ethanolamine, which were used for oxonorbornene monomer synthesis, were purchased from Sigma-Aldrich and used as received. Solvents needed for the synthesis including toluene (dry), tetrahydrofurane (dry), dichloromethane (freshly distilled from CaH2), and n-hexane were purchased from Carl Roth. A Grubbs second-generation catalyst was purchased from Sigma-Aldrich; it was reacted with pyridine to form a Grubbs third-generation catalyst using a previously reported procedure.26 (link) 1H NMR spectra were recorded on a Bruker 250 MHz spectrometer (Bruker, Madison, WI) to confirm the molecular structure of the oxonorbornene monomers and polymers. The molecular mass and mass distribution of the polymers were studied by gel permeation chromatography (GPC) using an Agilent GPC system with chloroform as eluent, PSS SDV columns (PSS, Mainz, Germany), and poly(methyl methacrylate) standards.
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3

Synthesis of Radical Polymerization Reagents

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Phosphate-buffered
saline (PBS) solutions were
prepared using preformulated tablets (Sigma-Aldrich) in 200 mL of
Milli-Q water (>18.2 Ω mean resistivity) to give [NaCl] =
0.138
M, [KCl] = 0.0027 M, and pH 7.4. Vinyl acetate (>99%), styrene
(>99%),
and isopropenyl acetate (99%) were purchased from Sigma-Aldrich and
were filtered through a plug of basic alumina to remove inhibitors
prior to use. 4,4′-Azobis(4-cynaovaleric acid) (>98%) was
recrystallized
from methanol and stored at −18 °C in the dark. Maleic
anhydride (99%), benzyl bromide (98%), 2-cyano-2-propyl benzodithioate
(>97%), N-Boc-ethanolamine (98%), 2-dimethylaminoethanol (99.5%),
2-(diethylamino)ethanol (>99.5%), 2-(diisopropylamino)ethanol (>99%),
and trifluoroacetic acid (99%) were purchased from Sigma-Aldrich.
Potassium ethyl xanthate (98%) was purchased from Alfa Aesar. All
solvents were purchased from VWR or Sigma-Aldrich and used without
further purification. S-benzyl O-ethyl carbondithioate was synthesized by Thomas Congdon.41 (link)
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