Pramipexole dihydrochloride was purchased from Tocris (Minneapolis, MN, USA), and cocaine hydrochloride was provided by the Drug Supply Program at the National Institute on Drug Abuse (Bethesda, MD). Both pramipexole and cocaine were dissolved in sterile, physiologic saline. Cocaine was administered intravenously (IV) in a volume of 0.1 ml/kg, whereas pramipexole was administered IP in a volume of 1 ml/kg.
Pramipexole dihydrochloride
Manufactured by Bio-Techne
Sourced in United States
Pramipexole dihydrochloride is a chemical compound used in laboratory settings. It functions as a dopamine receptor agonist, primarily targeting the D2 and D3 subtypes of dopamine receptors.
Automatically generated - may contain errors
2 protocols using pramipexole dihydrochloride
1
Pramipexole and Cocaine Administration
2
Pharmacological Pretreatment in 6-OHDA Rat Model
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
The following drugs were used: benserazide hydrochloride, 3,4-dihydroxy-l-phenylalanine (L-DOPA), 6-hydroxydopamine hydrochloride (6-OHDA) and desipramine hydrochloride (Sigma-Aldrich, St. Louis, MO, USA), pramipexole dihydrochloride (Tocris, Bristol, UK) and reboxetine mesylate (Abcam Biochemicals, Cambridge, UK). 6-OHDA was dissolved in saline containing 0.02% ascorbic acid and locally injected in the brain. Desipramine (25 mg/kg, i.p.), pramipexole (0.6 mg/kg, s.c.), reboxetine (20 mg/kg, i.p.) and L-DOPA [10 mg/kg, i.p.; administered together with the peripheral DOPA decarboxylase inhibitor, benserazide (7.5 mg/kg)] were dissolved in saline. All drugs were injected in a volume of 10 ml/kg. Desipramine was administered 30 min before the injection of 6-OHDA. The other drugs were administered for four consecutive days preceding the experiment. The animals were tested 30 min after the last drug administration.
About PubCompare
Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.
We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.
However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.
Ready to get started?
Sign up for free.
Registration takes 20 seconds.
Available from any computer
No download required
Revolutionizing how scientists
search and build protocols!