Gsk4027

Manufactured by Cayman Chemical

GSK4027 is a synthetic compound developed by Cayman Chemical. It is a pharmacological tool used in research applications. The core function of GSK4027 is to act as a potent and selective inhibitor of a specific molecular target. Further details about the intended use or applications of this product are not available.

Automatically generated - may contain errors

Lab products found in correlation

Succinic acid, by Merck Group (1 mentions) Sodium chloride (nacl), by Thermo Fisher Scientific (1 mentions) Ethylenediaminetetraacetic acid, by Thermo Fisher Scientific (1 mentions) Calcium chloride, by Merck Group (1 mentions) Imidazole, by Merck Group (1 mentions) Magnesium sulfate, by Merck Group (1 mentions) Sodium phosphate, by Thermo Fisher Scientific (1 mentions) Copper 2 chloride, by Thermo Fisher Scientific (1 mentions) Boric acid, by Mallinckrodt (1 mentions) Dimethyl sulfoxide d6, by Cambridge Isotopes (1 mentions) Deuterium oxide, by Cambridge Isotopes (1 mentions) Iron iii chloride, by Merck Group (1 mentions)

2 protocols using gsk4027

Detailed Preparation of Enriched Compounds

Cited 1 time

Check if the same lab product or an alternative is used in the 5 most similar protocols

The 3D-enriched fragment library was purchased from Life Chemicals and divided into mixtures of 4–5 fragments as previously described [11 (link)]. Amino acids, uracil, thiamine-HCl, LB broth, biotin, and nicotinic acid were purchased from RPI Corp. The 5-fluoroindole, magnesium sulfate, succinic acid, calcium chloride, Iron(III) chloride, ¹⁵N ammonium chloride, L-Moses, and imidazole were purchased from Millipore Sigma. Potassium diphosphate, potassium monophosphate, sodium phosphate, manganese (II) chloride, zinc(I) chloride, and sodium chloride were purchased from Fischer Scientific. Cobalt (II) chloride, Ethylenediaminetetraacetic acid, and copper (II) chloride was purchased from Acros Organics. Boric acid was purchased from Mallinckrodt. Deuterium oxide and dimethyl sulfoxide-d6 were purchased from Cambridge Isotope Laboratories. GSK4027 was purchased from Cayman Chemicals and TP238 was synthesized previously [55 (link)].

Johnson J.A., Olson N.M., Tooker M.J., Bur S.K, & Pomerantz W.C. (2020). Combined Protein- and Ligand-Observed NMR Workflow to Screen Fragment Cocktails against Multiple Proteins: A Case Study Using Bromodomains. Molecules, 25(17), 3949.

+ Open protocol

+ Expand

Synthesis of 4,5-Dichloropyridazinone Derivatives

Cited 1 time

Check if the same lab product or an alternative is used in the 5 most similar protocols

4,5-dichloropyridazin-3(2H)-one (1.0 eq.) was stirred in DMF (5 mL) followed by addition of sodium hydride (1.1 eq) and the alkyl bromide (1.4 eq.). The reaction mixture was stirred at room temperature for 12 h. Following completion of the reaction, the reaction mixture was extracted into ethyl acetate, washed with distilled water and finally with brine. The organic layer was dried over magnesium sulfate, filtered, concentrated in vacuo and purified by flash column chromatography (CombiFlash Rf system: 24 g silica, hexanes/ethyl acetate, 0–100% ethyl acetate, 20 minutes).
GSK4027 was purchased from Cayman Chemicals. The synthesis and characterization of compounds 1-3 were described previously.^{36 (link)}

Zahid H., Buchholz C.R., Singh M., Ciccone M.F., Chan A., Nithianantham S., Shi K., Aihara H., Fischer M., Schonbrunn E., dos Santos C.O., Landry J.W, & Pomerantz W.C. (2021). New design rules for developing potent, cell-active inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF bromodomain inhibition. Journal of medicinal chemistry, 64(18), 13902-13917.

+ Open protocol

+ Expand

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Revolutionizing how scientists
search and build protocols!