Serum liver enzymes (ALT and GGT) were measured by standard clinical chemical methods on an Abbott Architect clinical chemistry analyzer following the recommendations of the assay manufacturer (Abbott Laboratories, Abbott Park, IL, USA). High-sensitivity CRP, a biomarker of inflammation, was determined using a latex immunoassay (Sentinel Diagnostics, Milan, Italy) with the Abbott Architect c8000 clinical chemistry analyzer. Lipid profiles included determinations of total cholesterol, high-density lipoprotein-associated cholesterol (HDL), low-density lipoprotein (LDL) and total triglycerides using standard enzymatic methods. The cut-offs for the normal limits of the different biomarkers were as follows: ALT (50 U/L men; 35 U/L women), GGT (60 U/L men; 40 U/L women), CRP (3.0 mg/L), cholesterol (5 mmol/L), HDL cholesterol (1.0 mmol/L men, 1.2 mmol/L women), LDL cholesterol (3.0 mmol/L), triglycerides (1.7 mmol/L). Fatty liver index, a predictor algorithm for fatty liver disease, was analyzed based on BMI, waist circumference, triglycerides and GGT, as previously described [13 (link),20 (link)].
Architect c8000 clinical chemistry analyzer
Manufactured by Abbott
Sourced in United States, Italy
The ARCHITECT c8000 Clinical Chemistry Analyzer is a fully automated laboratory instrument designed for the analysis of various clinical chemistry tests. It is capable of performing a wide range of diagnostic tests, including the measurement of enzymes, proteins, electrolytes, and other analytes in biological samples. The ARCHITECT c8000 is engineered to provide accurate and reliable results, enabling healthcare professionals to make informed clinical decisions.
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Lab products found in correlation
7 protocols using architect c8000 clinical chemistry analyzer
1
Metabolic Biomarkers Evaluation Protocol
2
Serum Biomarkers of Liver Function and Inflammation
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Serum liver enzymes (ALT and GGT) were measured by standard clinical chemical methods on an Abbott Architect clinical chemistry analyzer following the recommendations of the assay manufacturer (Abbott Laboratories, Abbott Park, IL, USA). High-sensitivity CRP, a biomarker of inflammation, was determined using a latex immunoassay (Sentinel Diagnostics, Milan, Italy) with the Abbott Architect c8000 clinical chemistry analyzer. Lipid profiles included determinations of total cholesterol, high-density lipoprotein-associated cholesterol (HDL), low-density lipoprotein (LDL) and total triglycerides using standard enzymatic methods. All laboratory tests were subjects to continuous external quality control programs organized by Labquality, Finland and CDC (Center for Disease Control and Prevention) quality assurance and standardization program for serum lipids. The cut-offs for the normal limits of the different markers were as follows: ALT (50 U/L men; 35 U/L women), GGT (60 U/L men; 40 U/L women), CRP (3.0 mg/L), cholesterol (5 mmol/L), HDL cholesterol (1.0 mmol/L men, 1.2 mmol/L women), LDL cholesterol (3.0 mmol/L), triglycerides (1.7 mmol/L).
3
Comprehensive Assessment of Cardiometabolic Risk
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The variables analyzed were sociodemographics, BMI, adherence, and clinical data. The clinical data were blood pressure, blood lipids, blood glucose, UACR, and eGFR. Weight was measured with a digital scale and height with a Microtoise. Patient adherence was scored using pill counts and a Morisky, Green, and Levine Medication Adherence Questionnaire (MAQ).13 (link) Blood pressure was measured with a digital blood-pressure monitor and fasting blood glucose with a glucometer. UACR was measured with NycoCard™ U-Albumin (Abbott, USA) and eGFR was calculated using the CKD-EPI equation. Fasting lipid profiles (triglycerides, HDL cholesterol, total cholesterol, LDL cholesterol) and creatinine were measured using ARCHITECT c8000 Clinical Chemistry Analyzer (Abbott, USA).
4
Metabolic Profile Analysis in Mice
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After 4 h of fasting, mice were sacrificed and blood samples were collected. Serum triglycerides and cholesterol levels were determined in the ARCHITECT c8000 Clinical Chemistry Analyzer (Abbott, USA). Blood glucose levels were measured with the Accu-Chek Performance glucometer system (Roche Diagnostic, Germany). Plasma insulin levels were assayed using the Ultrasensitive Mouse-Insulin ELISA Kit (Mercodia, Sweden).
5
Serum Oxidative Status Measurement in Patients
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20 ml of venous blood was obtained from each patient and controls. Then serum was separated by centrifugation at 3000 rpm for 10 min. Serum CBZ level was assessed using a biochemical auto analyzer (ARCHITECT c8000 Clinical Chemistry analyzer, Abbott®, U.S., Japan). Total oxidative status (TOS) (9 (link)) and TAS of serum was determined using a novel automated measurement method developed by Erel (10 (link), 11 (link)). Oxidants present in the sample oxidize the ferrous ion-o-dianisidine complex to ferric ion. The oxidation reaction is enhanced by glycerol molecules, which are abundantly present in the reaction medium. The percent ratio of TOS to TAS yields the OSI, an indicator of the degree of oxidative stress (14 (link)). Percent rate of TOS level to TAS level was accepted as OSI (15 (link)). To apply the calculation, the result unit of TAS, mmol Trolox equivalent/l, was changed to mmol Trolox equivalent/l and the OSI value was calculated using following formula :
6
Dysglycemia Screening in Women
7
Inflammatory Markers in Suspected AA
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After completion of the image analysis process, medical records of patients with suspected diagnosis of AA were reviewed and WBC count (10 3 /µL), MPV (fL), RDW (%), NLR, and CRP level (mg/L) obtained on complete blood count (CBC) were noted. CBC was obtained just after the physical examination during initial referral. Laboratory analyses were performed using an Abbott ARCHITECT c8000 Clinical Chemistry Analyzer for all patients. NLR was calculated by dividing the percentage values of neutrophils and lymphocytes.
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