Methocel k100m cr

Manufactured by Colorcon

Sourced in Germany, United Kingdom, United States

Methocel K100M CR is a pharmaceutical grade cellulose derivative that functions as a binder and viscosity-increasing agent in various pharmaceutical formulations. It is a high viscosity, water-soluble polymer with a wide range of applications in the pharmaceutical industry.

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Lab products found in correlation

Kollidon va64, by BASF (1 mentions) Kleptose, by Roquette (1 mentions) Magnesium stearate, by Fagron (1 mentions) Kollidon cl sf, by BASF (1 mentions) Poloxamer 188, by BASF (1 mentions) Lactose, by Colorcon (1 mentions)

3 protocols using methocel k100m cr

Tolcapone Formulation Development and Evaluation

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The active substance under study is tolcapone (batches: SOM0114599 and SOM0714600) (CCN Industries LTD via Porschem Pharm).
The excipients studied are Vivapur^® 102 (JRS, Rosenberg, Germany), Avicel^® PH 101 (FMC Corp, Brusseles, Belgium), Kleptose^® (ROQUETTE, Roquette Frères, Lestrem, France), Kollidon^® VA 64 (BASF, Ludwigshafen, Germany), Prosolv^® HD90 (JRS, Rosenberg, Germany), Isomalt^® 721 (GalenIQ, Manheim, Germany), Methocel^® K100M CR (Colorcon, Dartford, UK), talc (Fagron, Terrassa, Spain), magnesium stearate (Fagron, Terrassa, Spain), and colloidal silicon dioxide (Fagron, Terrassa, Spain).

Nardi-Ricart A., Nofrerias-Roig I., Suñé-Pou M., Pérez-Lozano P., Miñarro-Carmona M., García-Montoya E., Ticó-Grau J.R., Insa Boronat R, & Suñé-Negre J.M. (2020). Formulation of Sustained Release Hydrophilic Matrix Tablets of Tolcapone with the Application of Sedem Diagram: Influence of Tolcapone’s Particle Size on Sustained Release. Pharmaceutics, 12(7), 674.

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Hydration Behavior of Xanthan Gum

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Xanthan gum (XG) (XANTURAL^® 75) was kindly provided by CP Kelco Ltd. (Leatherhead, UK) and had a molecular weight of approximately 2,000,000 Da [51 ,52 (link)]. Polyethylene oxide (PEO) MW 4,000,000 (POLYOX^™) and hydroxypropyl methylcellulose (HPMC) 2208, 100,000 cps grade (Methocel K100M CR) were kind gifts from Colorcon, Dartford, UK. Deionised water was used as the dissolution media for all hydration studies.

Ward A., Brown B., Walton K., Timmins P., Conway B.R, & Asare-Addo K. (2020). Application of Focus Variation Microscopy and Dissolution Imaging in Understanding the Behaviour of Hydrophilic Matrices. Pharmaceutics, 12(12), 1162.

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Carvedilol Formulation Development and Optimization

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Carvedilol was received as gift sample from Incpeta Pharmaceuticals Ltd. Bangladesh. Merhocel K4M CR, Methocel K100M CR and Lactose were obtained from Colorcon, USA. Microcrystalline Cellulose (Avicel PH 102) was purchase from Hanau Chemicals ltd. Japan. Magnesium stearate and talc were procured from Wilfrid Smith Ltd. UK. Poloxamer 188 and Kollidon-CLSF were obtained from BASF, Germany. PEG 6000 (Micronized grade) was donated by Beximco Pharmaceuticals Ltd, Bangladesh.

Boidya J., Hasan I., & Reza M.S. (2020). Carvedilol Matrix Tablet: Formulation and In Vitro Assessment. Bangladesh Pharmaceutical Journal, 23(1), 26-31.

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