Dynamic PET images were corrected for motion using frame-by-frame realignment in Voiager software (GE Healthcare, Uppsala, Sweden). The T1-weighted MRI scans were co-registered to a summation image (0–5 min) of their corresponding PET volume and segmented into grey matter, white matter and CSF using SPM8 (Wellcome Trust Center for Neuroimaging, University College London, UK). VOIs were defined on the MRI images using a probabilistic atlas (PVElab)(Svarer et al., 2005 (link)) and projected onto the dynamic PET images to extract regional TACs. VOIs included in the analysis were: midbrain, hippocampus, amygdala, thalamus, putamen, sensory motor, occipital, entorhinal, frontal, temporal and parietal cortex Left and right side VOIs were averaged. In addition, a white matter VOI and a whole brain grey matter VOI were included, and a grey matter cerebellar VOI as reference region.
Voiager software
Manufactured by GE Healthcare
Sourced in Sweden
Voiager software is a digital imaging platform developed by GE Healthcare. It provides tools for managing, analyzing, and sharing medical images and related data. The software is designed to integrate with various imaging modalities and support the workflow of healthcare professionals.
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2 protocols using voiager software
1
Motion-corrected Dynamic PET Analysis
2
Radiosynthesis and PET Imaging of (S)-18F-THK5117
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The radiosynthesis of (S)-18 F-THK5117 is described in the supplemental material (available at http://jnm.snmjournals.org). All (S)-18 F-THK5117 PET scans were obtained on an ECAT Exact HR1 (Siemens) stand-alone PET scanner. After a 10-min transmission scan with rotating 68 Ge rod sources, (S)-18 F-THK5117 (3 MBq/kg) was administered as a fast bolus, simultaneously with the start of a 90-min dynamic PET acquisition (6 • 10, 3 • 20, 2 • 30, 2 • 60, 2 • 150, 4 • 300, and 6 • 600 s). Images were reconstructed using normalization-and attenuationweighted ordered-subset expectation maximization (6 iterations, 8 subsets) applying all appropriate corrections and a 4-mm Hanning postprocessing filter. In addition, all patients underwent a T1-weighted MRI scan, which was used for segmentation and volume-of-interest (VOI) definition. The AD patients and MCI patients underwent MRI scans on a Magnetom Symphony 1.5-T (Siemens; n 5 2 and 1, respectively), Magnetom Trio 3-T (Siemens; n 5 2 and 1, respectively), or Achieva 1.5-T (Philips; n 5 1 and 2, respectively) scanner. The dynamic PET data were realigned to correct for interframe patient movement using Voiager software (GE Healthcare).
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