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Phoenix 1

Manufactured by Pharsight
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Sourced in United States

Phoenix 1.4 is a comprehensive software solution designed for data analysis, visualization, and reporting in the pharmaceutical and biotech industries. It provides a robust platform for modeling and simulation, enabling users to effectively analyze and interpret complex data.

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Lab products found in correlation

Winnonlin, by Pharsight (1 mentions)

Close spelling variants of this product

Phoenix Suite version 1.3 WinNonlin Phoenix Version 6.2.1 or higher Phoenix WinNonlin software 6·1

2 protocols using phoenix 1

1

Pharmacokinetics of Inhibitor FB23-2

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Inhibitor FB23-2 was formulated in DMSO at 3 mg/ml. SD rat (male, 7 – 8 weeks old, n = 3) were treated intraperitoneally with 1 ml/kg formulated compound. Blood samples were collected by retro-orbital bleeding at 5 min, 0.25, 0.5, 1, 2, 4, 6, 8, and 24 hr after the intraperitoneal administration. Blood was collected into EDTA-containing tubes and plasma was obtained by centrifugation at 2,000 g for 5 min. FB23-2 and its hydrolysis metabolite FB23 concentrations in plasma were quantitated by LC-MS/MS method. Noncompartmental analysis with Phoenix 1.4 (Pharsight, USA) was used for all analytical measurements. Area under the concentration-time curve (AUC) was calculated using trapezoidal method. AUC0−∞ = AUC0-t + Ct/ke, ke is elimination rate constant. Elimination half-life (T1/2) = 0.693/ke, mean residence time (MRT) = AUMC/AUC.
Huang Y., Su R., Sheng Y., Dong L., Dong Z., Xu H., Ni T., Zhang Z.S., Zhang T., Li C., Han L., Zhu Z., Lian F., Wei J., Deng Q., Wang Y., Wunderlich M., Gao Z., Pan G., Zhong D., Zhou H., Zhang N., Gan J., Jiang H., Mulloy J.C., Qian Z., Chen J, & Yang C.G. (2019). Small-molecule targeting of oncogenic FTO demethylase in acute myeloid leukemia. Cancer cell, 35(4), 677-691.e10.
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2

ELOSA for Aptamer Plasma Levels

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The plasma levels of aptamers were measured by using an enzyme-linked oligo-sorbent assay (ELOSA) according to the method reported by Healy et al. [18 (link)]. The RNA sequences of the detection probe and capture probe were 5′-6-FAM-spacer 18-GGGUACCGAUUACUG-3′ and 5′-ACUCCUCCGGCUACCC-spacer 9-amino C6 linker-3′, respectively. The PK parameters were derived by using noncompartmental models with WinNonlin® version 6.4 on Phoenix® 1.4 (Pharsight Corp., Mountain View, CA).
Haruta K., Otaki N., Nagamine M., Kayo T., Sasaki A., Hiramoto S., Takahashi M., Hota K., Sato H, & Yamazaki H. (2017). A Novel PEGylation Method for Improving the Pharmacokinetic Properties of Anti-Interleukin-17A RNA Aptamers. Nucleic Acid Therapeutics, 27(1), 36-44.
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