As an inclusion criterion for this study, stereotactic MRI had been used for localization and target definition. Our standard protocol is to perform T2-weighted and proton density imaging using 1.5-mm slices, TE 80 msec, TR 3000 msec, 256 matrix, number of signal averages 1. Gam-maPlan (Elekta AB) was used for dose planning. Treatments were delivered with the Gamma Knife model RBS 5000 (Nucletec) until 2001, Gamma Knife Model C (Elekta AB) until 2011, and Gamma Knife Perfexion (Elekta AB) thereafter in the RHH and all with Perfexion in the TRC. The number of treated patients gradually increased from 3 in 1995 to an annual average of 20 more recently (Fig. 2A). The median time between presentation and treatment was 1 year (0.1-34 years). Cavernous malformations were defined within the hemosiderin ring and were treated after complete resolution of the last hematoma, and a median dose of 12-13 Gy (depending on location) was given to the 50% prescription isodose level, excluding coexisting developmental venous anomalies. 27 Our standard treatment protocol has not changed essentially since 1995, apart from a significant reduction in the prescription dose from 15 to 12 Gy after 2000 (p < 0.001; Table 2).
Gamma knife model c
Manufactured by Elekta
The Gamma Knife Model C is a radiation therapy device designed for stereotactic radiosurgery. It utilizes multiple beams of gamma radiation to precisely target and treat small intracranial lesions. The device is equipped with a helmet-like collimator that focuses the radiation beams on the target area, minimizing exposure to surrounding healthy tissue.
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Lab products found in correlation
5 protocols using gamma knife model c
1
Stereotactic MRI-Guided Gamma Knife Radiosurgery
2
Gamma Knife Radiosurgery for Brain Tumors
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SRS was carried out using a Gamma Knife Model C (Elekta AB, Stockholm, Sweden). T1-, T2-, and enhanced T1-weighted magnetic resonance (MR) images with a slice thickness of 2 mm were used for the 3-dimensional reconstructions and treatment planning. The MR images were transferred to a workstation for post-processing and analysis. The Gamma Plan system was used to determine the GKRS for all patients. To deliver a highly conformal dose to the tumor, multiple small isocenters were used. The volume of the tumor ranged from 0.8 cc to 14.6 cc (median, 5.0 cc). The median marginal dose was 12.5 Gy (8-14 Gy). In all patients, the 50% isodose line was used for the margin. The maximal radiation doses varied between 16 and 28 Gy (median, 25.0 Gy). The size of each tumor and PTE, before and 6 months after GKRS, was retrospectively measured using the Gamma Plan workstation and picture archiving and communicating system system.
3
Stereotactic Radiosurgery for Cerebral Cavernous Malformations
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SRS was carried out using a Gamma Knife Model C (Elekta AB, Stockholm, Sweden). T1-, T2-, and enhanced T1-weighted magnetic resonance imaging (MRI) with a slice thickness of 2 mm was used for 3-dimensional reconstructions and treatment planning. The MRIs were transferred to a workstation for post-processing and analysis. The Gamma Plan system was used to determine the SRS for all patients. Multiple small isocenters were used to deliver a highly conformal dose to the lesion. CCM volume ranged from 0.08 to 4.8 mL (mean, 1.57 mL). Mean marginal dose was 14.5 Gy (range, 13–16 Gy). The 50% isodose line was used as the margin in all patients. Maximum radiation dose was 26–32 Gy (mean, 29 Gy).
Rebleeding after SRS was defined as imaging evidence of a new blood density corresponding to a new neurological sign or symptom. Follow-up MR imaging was requested at 6-month intervals during the first 2 years after SRS, after which it was recommended on an annual basis.
Rebleeding after SRS was defined as imaging evidence of a new blood density corresponding to a new neurological sign or symptom. Follow-up MR imaging was requested at 6-month intervals during the first 2 years after SRS, after which it was recommended on an annual basis.
4
Gamma Knife Stereotactic Radiosurgery for Tumors
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SRS was carried out using a Gamma Knife Model C (Elekta AB, Stockholm, Sweden). T1-, T2-, and enhanced T1-weighted magnetic resonance imaging (MRI) with a slice thickness of 2 mm was used for three-dimensional reconstructions and treatment planning. The MRIs were transferred to a workstation for post-processing and analysis. The Gamma Plan system was used to determine the GKS for all patients. Multiple small isocenters were used to deliver a highly conformal dose to the tumor. Tumor volume ranged from 1.1 to 4.9 mL (mean, 2.3 mL). Mean marginal dose was 13.6 Gy (range, 12-15 Gy). The 50% isodose line was used as the margin in all patients. Maximum radiation dose was 24-30 Gy (mean, 27.2 Gy). The size of each tumor before and 6 months and 1 and 2 years after GKS was measured retrospectively using the Gamma Plan workstation and a picture archiving communication system. Tumor progression was defined as an increase in tumor volume of at least 10%. Tumor regression was defined as at least a 10% decrease in tumor volume. Tumors that were ±10% of their original volume were defined as stable [7 (link)].
5
Gamma Knife Stereotactic Radiosurgery
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The Leksell stereotactic head frame was attached to the patient's head using local anesthesia (model G, Elekta AB). Imaging was based on contrast-enhanced T1-weighted sequences plus T2-weighted MR sequences with 1.6-mm slice thickness using high-resolution 1.5-T MRI (Genesis Sigma, General Electric). Stereotactic images were imported into the GammaPlan workstation (Elekta AB). The treatment was performed using the Gamma Knife Model C (Elekta Instruments, Inc.). The target volume was drawn in all the MRI slices.
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