Female nod scid mice

Manufactured by Taconic Biosciences

Sourced in Denmark, United States

The Female NOD/SCID mice are a strain of immunodeficient rodents. They are characterized by the absence of mature T and B cells, as well as functional natural killer cells. These mice serve as a useful tool for the study of human cell and tissue engraftment.

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Lab products found in correlation

Ivis lumina 2 in vivo imaging system, by PerkinElmer (1 mentions)

2 protocols using female nod scid mice

Tumor Growth in NOD/SCID Mice

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Female NOD/SCID mice (n = 3) purchased from Taconic (Denmark) were inoculated at day 0 with 10⁷ cells of the MKN28 HIF- or SCR cells. Tumor growth was monitored twice per week by caliper measurements and calculation of tumor volumes (TV). The animal experiments were approved by the local ethical committee (LaGeSo Berlin) and performed according to the “Guidelines for the welfare and use of animals in cancer research” [55 (link)].

Rohwer N., Bindel F., Grimm C., Lin S.J., Wappler J., Klinger B., Blüthgen N., Du Bois I., Schmeck B., Lehrach H., de Graauw M., Goncalves E., Saez-Rodriguez J., Tan P., Grabsch H.I., Prigione A., Kempa S, & Cramer T. (2015). Annexin A1 sustains tumor metabolism and cellular proliferation upon stable loss of HIF1A. Oncotarget, 7(6), 6693-6710.

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Late-Stage Disseminated Breast Cancer Murine Model

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Female NOD/scid mice from Taconic (Rensselaer, NY, USA) were engrafted i.p. with 5.0×10⁶ cells (404 tumor line, Brca2^−/−, Tp53^−/−, Pten^−/−) to mimic late stage, disseminated disease. One week after engraftment, the animals underwent bioluminescence imaging (IVIS Lumina II In Vivo Imaging System, PerkinElmer Inc.) to determine a baseline of tumor burden, followed by separation into six groups.

Baldwin P., Ohman A.W., Tangutoori S., Dinulescu D.M, & Sridhar S. (2018). Intraperitoneal delivery of NanoOlaparib for disseminated late-stage cancer treatment. International Journal of Nanomedicine, 13, 8063-8074.

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