Pirarubicin

Manufactured by Selleck Chemicals

Sourced in United States

Pirarubicin is a lab equipment product that functions as a chemotherapeutic agent. It is a derivative of the anthracycline antibiotic doxorubicin.

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Lab products found in correlation

Mcl 1, by Proteintech (1 mentions) Caspase 3 7 inhibitor 1, by Apexbio (1 mentions) β catenin, by Proteintech (1 mentions) Gapdh, by Proteintech (1 mentions) Bcl 2, by Proteintech (1 mentions) Peroxidase conjugated goat anti rabbit igg, by ZSGB-BIO (1 mentions) Doxorubicin dox, by Merck Group (1 mentions) Cisplatin cddp, by Merck Group (1 mentions) Paclitaxel, by Selleck Chemicals (1 mentions) Epirubicin, by Selleck Chemicals (1 mentions) Doxorubicin, by Selleck Chemicals (1 mentions) Cck 8, by Dojindo Laboratories (1 mentions) Tariquidar, by Selleck Chemicals (1 mentions)

3 protocols using pirarubicin

Protein Expression and Apoptosis Analysis

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Membrane‐associated RING‐CH‐1 (Bioss, bs‐9335, Beijing, China), Phospho‐AKT Ser473 (SAB, 11054, Randallstown, MD, USA), total AKT (SAB, 21054), GAPDH (Proteintech, 10494‐1‐AP, Wuhan, Hubei, China), PI3K p110 β (Proteintech, 20584‐1‐AP), β‐catenin (Proteintech, 51067‐2‐AP), Mcl‐1 (Proteintech, 16225‐1‐AP), Bcl‐2 (Proteintech, 12789‐1‐AP), Cleaved caspase‐3 (CST, 9661, Fall River, MA, USA), Cleaved caspase‐7 (CST, 8438), secondary antibodies (Peroxidase‐conjugated Goat anti‐Rabbit IgG; ZSGB‐BIO, ZB‐2301, Beijing, China), Caspase‐3/7 Inhibitor I (ApexBio,A1925, Houston, TX, USA) and Pirarubicin (Selleck, Houston, TX, USA) were obtained commercially.

Xie L., Dai H., Li M., Yang W., Yu G., Wang X., Wang P., Liu W., Hu X, & Zhao M. (2019). MARCH1 encourages tumour progression of hepatocellular carcinoma via regulation of PI3K‐AKT‐β‐catenin pathways. Journal of Cellular and Molecular Medicine, 23(5), 3386-3401.

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Preparation of Chemotherapeutic Agents

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Doxorubicin (Dox) and cisplatin (CDDP) were purchased from Sigma-Aldrich (St. Louis, MO, USA), and dissolved in DMSO at a stock concentration of 100 mM and 50 mM, respectively. Epirubicin, pirarubicin and paclitaxel were purchased from Selleckchem (Houston, TX, USA), and dissolved in DMSO at a stock concentration of 100 mM, 20 mM and 50 mM, respectively.

Zhu Q.N., Wang G., Guo Y., Peng Y., Zhang R., Deng J.L., Li Z.X, & Zhu Y.S. (2017). LncRNA H19 is a major mediator of doxorubicin chemoresistance in breast cancer cells through a cullin4A-MDR1 pathway. Oncotarget, 8(54), 91990-92003.

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Drug Synergy Evaluation in Cancer Cells

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Pirarubicin and Doxorubicin and Tariquidar were obtained from Selleck, CCK8 reagents from DOJINDO.

Zhou Z., Xiong L., Wu Z., Jiang L., Li Y., Li Z., Peng Y., Ning K., Zou X., Liu Z., Wang J., Li Z., Zhou F., Liu Z., Zhang Z, & Yu C. (2022). Nkx2.8 promotes chemosensitivity in bladder urothelial carcinoma via transcriptional repression of MDR1. Cell Death & Disease, 13(5), 492.

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