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Polyvinylpyrrolidone pvp k30

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Polyvinylpyrrolidone (PVP K30) is a synthetic water-soluble polymer commonly used in various industries. It is a versatile material with a range of applications. PVP K30 is a white, free-flowing powder with a molar mass of approximately 40,000 g/mol. Its core function is to serve as a binder, stabilizer, and suspending agent in various formulations.

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Lab products found in correlation

Acetone, by Thermo Fisher Scientific (2 mentions) Poloxamer 407, by BASF (2 mentions) Sodium stearyl fumarate, by JRS Pharma (1 mentions) Polyplasdone xl, by Ashland (1 mentions) Sodium carboxymethyl cellulose, by Merck Group (1 mentions) Potassium dihydrogen phosphate kh2po4, by Merck Group (1 mentions) Hydroxypropyl methylcellulose hpmc, by Shin-Etsu Chemical (1 mentions) Sodium alginate, by Thermo Fisher Scientific (1 mentions) Dexamethasone (dex), by Thermo Fisher Scientific (1 mentions) Curcumin cur, by Enzo Life Sciences (1 mentions) Kolliphor el krel, by BASF (1 mentions) Acitretin, by Merck Group (1 mentions) Sodium deoxycholate, by Thermo Fisher Scientific (1 mentions) D sucrose, by Merck Group (1 mentions) Ethylenediaminetetraacetic acid, by Leco (1 mentions) Bovine serum albumin (bsa), by Merck Group (1 mentions) Sodium lauryl sulfate, by BASF (1 mentions) Indomethacin, by Thermo Fisher Scientific (1 mentions) Milli q advantage a10, by Merck Group (1 mentions) Isopropyl alcohol, by Thermo Fisher Scientific (1 mentions)

Spelling variants of this product

PVP K30 (19 citations) Polyvinylpyrrolidone (15 citations) Polyvinylpyrrolidone K30 (9 citations) Polyvinylpyrrolidone K30 (PVP K30) (6 citations)

12 protocols using polyvinylpyrrolidone pvp k30

1

Synthesis of Pt-decorated CdS Nanoparticles

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All chemicals were used without further purification. Chloroplatinic acid (H2PtCl6·6H2O) was obtained from Reagent No. 1 Factory of Shanghai Chemical Reagent Co., Ltd. Sodium borohydride (NaBH4) was obtained from Chinese Sinopharm Chemical Reagent Co. Ltd. Polyvinylpyrrolidone (PVP, K30) was obtained from BASF. Cd(NO3)2·4H2O, NH2CSNH2, NiCl2·6H2O (Kermel Chemical Reagent Co. Ltd.) and absolute alcohol (Ante Biotech Co. Ltd.) were used as starting materials. The water used in the preparation was distilled water.
Mao L., Ba Q., Jia X., Liu S., Liu H., Zhang J., Li X, & Chen W. (2019). Ultrathin Ni(OH)2 nanosheets: a new strategy for cocatalyst design on CdS surfaces for photocatalytic hydrogen generation. RSC Advances, 9(3), 1260-1269.
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2

Choline Alfoscerate Tablet Formulation

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Choline alfoscerate was purchased from HanseoChem (Pyeongtaek, Republic of Korea). Neusilin® (magnesium aluminometasilicate; Fuji Chemical, Osaka, Japan) was used to control the water absorption of drug and to improve the granule fluidity. Polyvinylpyrrolidone (PVP) K-30 (BASF, Ludwigshafen, Germany) was added as a binder. Micro-crystalline cellulose (Mingtai Chemical, Mountainside, Bah-Der, Taiwan), lactose monohydrate and lactose anhydrous (DFE Pharma, Goch, Germany), and dicalcium phosphate anhydrous (A-TAB; Innophos, Cranbury, NJ, USA) were used as excipients for the tablets. Croscarmel-lose sodium (DFE Pharma), sodium starch glycolate (Yung Zip, Taichung, Taiwan), crospovidone (Polyplasdone XL; Ashland, Covington, KY, USA), magnesium stearate (FACI, Carasco, Italy), and sodium stearyl fumarate (Pruv; JRS Pharma, Rosenberg, Germany) were used as superdisin-tegrant and lubricant, respectively. Opadry I® and Opadry AMB® were obtained from Colorcon (Shanghai, China). Gliatilin® soft capsules (Daewoong Pharmaceutical, Seoul, Republic of Korea) were purchased from a local pharmacy.
Min M.H., Park J.H., Hur J.H., Shin H.C., Cho Y, & Kim D.D. (2019). Formulation and bioequivalence studies of choline alfoscerate tablet comparing with soft gelatin capsule in healthy male volunteers. Drug Design, Development and Therapy, 13, 1049-1058.
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3

Loxoprofen Formulation Development

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The active drug loxoprofen was purchased from Shanghai United Chemicals Co., Ltd. (Shanghai, China), and hydroxypropyl methylcellulose (HPMC) from Shin-Etsu Chemical Co., Ltd. (Tokyo, Japan), with type of substitution 2910, Grade 615, 15cp viscosity. The polyvinyl pyrrolidone (PVP K-30), batch no. 08297047GO, was purchased from BASF, Heidelberg, Germany, and potassium dihydrogen phosphate (KH2PO4) from Merck KGaA, Darmstadt, Germany. Sodium lauryl sulfate (SLS), batch no. 35880, sodium chloride (NaCl), and Pluronic 407 and sodium carboxymethyl cellulose (NaCMC) were all bought from Sigma Aldrich, St. Louis, MO, USA.
Khan B.A., Khalid H., Khan M.K., Hosny K.M., Khan S., Rizg W.Y., Safhi A.Y., Halwani A.A., Almehmady A.M, & Menaa F. (2022). Biodegradable Polymers-Based Smart Nanocrystals for Loxoprofen Delivery with Enhanced Solubility: Design, Fabrication and Physical Characterizations. Polymers, 14(17), 3464.
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4

Microneedle Patch for Transdermal Drug Delivery

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Dexamethasone (Alfa Aesar),
sodium alginate (SA, Fisher Chemical), and trypan blue powder (Thermo
Scientific) were purchased from Holland-Moran Inc., Israel. Silicone
MPatch microneedle templates were purchased from Micropoint Technologies
Pte Ltd. (Pioneer Junction, Singapore) and were pyramidal in shape
with dimensions of 10 × 10 needle array, 200 μm base, 500
μm height, and 500 μm pitch. Organic solvents and PEG
with average MWs of 3.4, 10, 35, and 100 kDa were purchased from Sigma
Aldrich. Poly(vinyl pyrrolidone) (PVP) K-30 (MW 40 kDa) was purchased
from BASF. Microcrystalline cellulose was supplied by FMC BioPolymer
(Avicel, Philadelphia, PA), and PLGA-Purasorb PDLG 5010 (50:50) was
donated by Corbion Purac (Gorinchem). Phosphate-buffered saline (PBS,
pH 7.4) was purchased from Hyclone Laboratories. GeBaFlex tubes with
a molecular weight cutoff (MWCO) of 8 kDa, porcine liver esterase
(PLE), and bovine serum albumin (BSA, Probumin) were purchased from
Merck.
Dawud H., Edelstein-Pardo N., Mulamukkil K., Amir R.J, & Abu Ammar A. (2024). Hydrogel Microneedles with Programmed Mesophase Transitions for Controlled Drug Delivery. ACS Applied Bio Materials, 7(3), 1682-1693.
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5

Solubility Enhancement of Lansoprazole and Curcumin

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Lansoprazole (LNS, purity = 99%) and curcumin (CUR, purity = 99.5%) were purchased from Enzo life Sciences, (Lausen, Switzerland). Imwitor 988 (medium chain mono and diglycerides C8–10), Kolliphor EL (KrEL), and polyvinylpyrrolidone (PVP-K30) were purchased from BASF, (Ludwigshafen, Germany). Hydrogenated castor oil (HCO30) was purchased from Nicole chemical co., (Tokyo, Japan). Neusilin® grade US2 was obtained from Fuji Chemical Co., (Toyama, Japan).
Alshadidi A., Shahba A.A., Sales I., Rashid M.A, & Kazi M. (2021). Combined Curcumin and Lansoprazole-Loaded Bioactive Solid Self-Nanoemulsifying Drug Delivery Systems (Bio-SSNEDDS). Pharmaceutics, 14(1), 2.
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6

Formulation of PLGA-based Implants

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50:50 acid end-capped PLGA 503H (24–38 kDa), was purchased from Evonik, 4HPR was generously supplied by Merck Co, and acitretin was used as an internal standard (analytical grade, Sigma-Aldrich). Excipients used were sodium deoxycholate, (NaDC, 99% pure, Acros), polyvinylpyrrolidone (PVP K30, 40 kDa, BASF), hydroxypropyl methylcellulose K4M (HPMC K4M, Dow Chemical, Midland, MI), and β-CD (Sigma-Aldrich). Calcium deoxycholate (CaDC) was synthesized according to literature methods described in Supplemental information. Water-soluble implants were composed of polyvinyl alcohol (PVA, 9–10 kDa, 80% hydrolyzed, Sigma-Aldrich) and D-sucrose (Sigma-Aldrich). All other materials were reagent grade or better including: MgCO3, acetone, ethanol (EtOH), tetrahydrofuran (THF), and Tween 80. Solvents for UPLC-UV and MS analysis were HPLC or MS grade including acetonitrile (ACN), methanol (MeOH), double distilled water (ddH2O), phosphoric acid (H3PO4), ammonium formate (NH4COO) and formic acid (HCOOH). Silicon tubing (0.8 mm i.d.,) was purchased from BioRad Laboratories. Ethylenediaminetetraacetic acid (EDTA, analytical standard, LECO, St. Joseph, MI) and Bovine Serum Albumin (BSA, 99% pure, heat shock fraction, Sigma-Aldrich) were used as standards for nitrogen analysis.
Nieto K., Pei P., Wang D., Mallery S.R, & Schwendeman S.P. (2017). In vivo controlled release of fenretinide from long-acting release depots for chemoprevention of oral squamous cell carcinoma recurrence. International journal of pharmaceutics, 538(1-2), 48-56.
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7

Indomethacin Solid Dispersion Formulation

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Indomethacin was purchased
from Acros Organics (Fisher Scientific, Geel, Belgium). Hydroxypropylmethylcellulose
2910, 5 mPa s (HPMC E5) was purchased from DDP Specialty Electronic
Materials (DDP Speciality Electronic Materials Plaquemine). Poloxamer
407, poly(vinylpyrrolidone) (PVP) K30, and sodium lauryl sulfate (SLS)
were obtained from BASF (BASF Chemtrade GmbH, Burghernheim, Germany).
Docusate sodium salt (DOSS) was purchased from Merck KGaA (Darmstadt,
Germany). Purified water was freshly prepared using a Milli-Q integral
water purification system (Milli-Q Advantage A10; Merck Millipore,
Merck A/S, Hellerup, Denmark). Ethanol for analysis was obtained from
Merck KGaA (Merck KGaA, Darmstadt, Germany). Acetone, laboratory reagent
grade ≥99%, was purchased from Fisher Scientific (Fisher Scientific,
Loughborough, U.K.). All suspensions were filtered with a Durapore
0.22 μm PVDF Membrane (Merck Millipore Ltd., Cork, Ireland)
prior to analysis by X-ray powder diffraction (PXRD) and scanning
electron microscopy (SEM).
Hugo Silva M., Kumar A., Hodnett B.K., Tajber L., Holm R, & Hudson S.P. (2022). Impact of Excipients and Seeding on the Solid-State Form Transformation of Indomethacin during Liquid Antisolvent Precipitation. Crystal Growth & Design, 22(10), 6056-6069.
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8

Topical Delivery System Development

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Fluorescein isothiocyanate (FITC)-Dextran (10 kDa) FITC- Albumin (66 kDa) and cellulose acetate were purchased from Sigma Aldrich, St. Louis, USA. Polyvinyl Pyrrolidone (PVP K30) was kindly gifted by BASF, New York, USA. Nile Red and Voriconazole was purchased from TCI Chemicals, Portland, USA. Toluene and Ethyl cellulose were purchased from Aqualon, Wilmington, USA. Ethyl acetate, acetone and isopropyl alcohol were purchased from Fisher Scientific, Waltham, USA. Lidocaine hydrochloride was purchased from yarrow pharma, Mumbai, India. The freshly excused pig ear skin and the eyes were obtained from the local abattoir in cold ice.
Jakka D., Matadh A.V., Shankar V.K., Shivakumar H.N, & Murthy S.N. (2022). Polymer Coated Polymeric (PCP) Microneedles for Controlled Delivery of Drugs (Dermal and Intravitreal). Journal of pharmaceutical sciences, 111(10), 2867-2878.
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9

Polymer Blends for Pharmaceutical Formulations

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Materials. GSF (purity > 99.5%, Form I), PEG (molecular weight, Mw: 200-10,000 g/mol) and PEO (Mw: 100,000-1,000,000 g/mol) were purchased from Aladdin (Shanghai, China). Poly (1,4-butylene adipate) (PBA, Mw = 12,000 g/mol) and poly(ethylene succinate) (PES, Mw = 10,000 g/mol) were purchased from Aldrich (St. Louis, MO, USA). Poloxamer 188 (Mw = 8,500 g/mol), polyvinylpyrrolidone (PVP K30, Mw = 50,000 g/mol), poly(1-vinylpyrrolidone-co-vinylacetate) (PVP VA64, Mw = 45,000 g/mol), and PEG 6000-vinylcaprolactam-vinyl acetate grafted polymer (Soluplus, Mw = 118,000 g/mol) were kindly supplied by BASF SE (Ludwigshafen, Germany).
Hydroxy propyl methyl cellulose acetate succinate (HPMCAS HF) was kindly supplied by Ashland (Wilmington, DE, USA).
Ou X., Li S., Chen Y., Rong H., Li A., & Lü M. (2021). Polymorphism in Griseofulvin: New Story of an Old Drug with Polyethylene Glycol.
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10

Micronization of Hydrophobic API Powder

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A hydrophobic highly insoluble API powder was provided by Sanofi R&D (Paris). It was micronized by jet milling before use. The physico-chemical properties of the API are given in Table 1.
Polyvinylpyrrolidone PVP (K30) (Molar mass: 30,000 g) was purchased from BASF (France), sodium dodecyl sulfate (SDS) was purchased from Univar (France), Vitamin E TPGS 1 (d-alpha tocopheryl polyethylene glycol 1000 succinate) was purchased from Eastman Chemical Company (Netherlands), Solutol 1 HS15 was purchased from BASF (France) and Sodium chloride was purchased from Sigma Aldrich (France).
Nakach M., Authelin J.R., Voignier C., Tadros T., Galet L, & Chamayou A. (2016). Assessment of formulation robustness for nano-crystalline suspensions using failure mode analysis or derisking approach. International journal of pharmaceutics, 506(1-2).
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