Croscarmellose sodium acdisol

Celecoxib (CXB), Eudragit S100, and hydroxypropyl methylcellulose acetate succinate LG (HPMCAS-LG) were supplied by Jansen Pharmaceutica (Beerse, Belgium). Capryol 90, Maisine CC, Peceol, Plurol oleique CC 497, and Labrasol were a gift from Gattefossé (Saint-Priest Cedex, France). Captex 200 P, Captex 355 EP/NF, and Capmul PG-8 NF were a gift from ABITEC Corporation (Columbus, OH, USA). Croscarmellose sodium (AcDiSol) was obtained from FMC BioPolymer (Philadelphia, PA, USA). Tween 20, isopropyl myristate, Cremophor RH40, PEG 400, tetraglycol, Patent Blue V, Povidone (PVP) K15, PVP K60, and PVP K90 were obtained from Sigma-Aldrich (St. Louis, MO, USA). Gelatine Licaps^® size 0 capsules were gifted by Capsugel (Bornem, Belgium). Macrogolum 6000 (PEG 6000), PVP K30, hydroxypropyl methylcellulose (HPMC) 5 and 4000 cps, talc, and gelatine were obtained from BUFA (IJsselstein, The Netherlands). Tween 80, 37% fuming hydrochloric acid, sodium chloride (NaCl), sodium dodecyl sulfate (SDS), tert-butyl alcohol (TBA), sodium dihydrogen phosphate dihydrate, and sodium hydroxide (NaOH) were obtained from MERCK (Darmstadt, Germany). Acetone and ethanol 70% were purchased from BOOM B.V. (Meppel, The Netherlands) and methanol from VWR Chemicals (Fontenay-sous-Bois, France). Millipore type 1 water was used in all experiments except for the dissolution media where demineralized water was used.

Polyvinylpyrrolidone with an average molecular weight of 360,000 (PVP-K90) was purchased from Spectrum Chemicals & Laboratory Products (New Brunswick, NJ, USA). 2-Hydroxypropyl beta cyclodextrin (HP-β-CD) with an average molecular weight of 1460 and d-α-tocopherol polyethylene glycol 1000 succinate (TPGS) were obtained from Sigma-Aldrich Inc. (St. Louis, MO, USA). Microcrystalline cellulose (Avicel PH 101) was purchased from Fluka (Hach Lange, Ireland). Croscarmellose sodium (Ac-Di-Sol) was obtained from FMC BioPolymer (Philadelphia, PA, USA). Talc powder was procured from Whittaker Clark & Daniels (South Plainfield, NJ, USA). Eudragit L100-55 was a kind gift from Rohm Pharma, GmbH (Weiterstadt, Germany). Magnesium stearate was procured from Winlab Laboratory Chemicals and Reagents (Leicestershire, UK). Lactose monohydrate spray-dried powder was purchased from Spectrum Chemical Mfg. Corp. (Gardena, CA, USA). Methanol was obtained from BDH Laboratory Reagents (Poole, England).