Dodecyl isocyanate

Manufactured by Merck Group

Dodecyl isocyanate is a chemical compound used in various industrial and laboratory applications. It is a colorless, oily liquid with a characteristic odor. Dodecyl isocyanate is primarily used as a reactive intermediate in the synthesis of other chemicals and materials.

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Lab products found in correlation

Hypromellose, by Merck Group (3 mentions) Oxaliplatin, by Merck Group (2 mentions) 2 hydroxyethyl disulfide, by Merck Group (2 mentions) Bone wax w31g, by Johnson & Johnson (2 mentions) Dimethyl sulfoxide (dmso), by Merck Group (2 mentions) Hydrogen peroxide, by Merck Group (2 mentions) Dimethylformamide, by Merck Group (2 mentions) Luciferin, by PerkinElmer (2 mentions) Mouse igg1 isotype control antibody clone mopc 21, by BioXCell (2 mentions) Histidine tagged human il 12, by Sino Biological (2 mentions) Sterile pbs, by Thermo Fisher Scientific (2 mentions) N methylpyrrolidone, by Merck Group (2 mentions) Phosphate buffered saline (pbs), by Thermo Fisher Scientific (2 mentions) Hydroxypropyl methylcellulose, by Merck Group (1 mentions) N n diisopropylethylamine, by Merck Group (1 mentions) Anhydrous n methyl 2 pyrrolidone, by Merck Group (1 mentions) Zinc nitrate hexahydrate, by Thermo Fisher Scientific (1 mentions) Chloroform, by Thermo Fisher Scientific (1 mentions) Imidazole, by Merck Group (1 mentions) N n dimethylformamide (dmf), by Thermo Fisher Scientific (1 mentions)

7 protocols using dodecyl isocyanate

Comprehensive Reagents and Materials for Research

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Dimethylformamide, dimethyl sulfoxide, oxaliplatin, hydrogen peroxide, dodecyl isocyanate, potassium tetrachloroplatinate(II), 1S,2S- diaminocyclohexane and 2-hydroxyethyl disulfide were purchased from Sigma-Aldrich. GSH (catalogue (cat.) no. 78259) and DiI (cat. no. D282) were purchased from Thermo Fisher Scientific. aCSF (cat. no. 59–7316) was procured from Harvard Apparatus. Isoflurane (SKU 029405), ketamine (SKU 056344), xylazine (SKU 061035), meloxicam (SKU 049755) and buprenorphine (SKU 055175) were purchased from Covetrus.
Bone wax (W31G) was obtained from Ethicon. Reflex 9 mm wound clips were from CellPoint Scientific. Triple antibiotic ointment (cat. no. 9004788) was obtained from Henry Schein. Polyimide microbore tubing (TPI-34×12) was bought from Professional Plastics. Epoxy 907 adhesive system was acquired from Miller-Stephenson. Betadine solution swabsticks were obtained from Betadine. Puralube vet ointment (17033-211-38) was procured from Dechra Veterinary Products. Luciferin (122799) was purchased from PerkinElmer.

Wang Y., Jiang Y., Wei D., Singh P., Yu Y., Lee T., Zhang L., Mandl H.K., Piotrowski-Daspit A.S., Chen X., Li F., Li X., Cheng Y., Josowitz A., Yang F., Zhao Y., Wang F., Zhao Z., Huttner A., Bindra R.S., Xiao H, & Saltzman W.M. (2021). Nanoparticle-mediated convection-enhanced delivery of a DNA intercalator to gliomas circumvents temozolomide resistance. Nature biomedical engineering, 5(9), 1048-1058.

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Lipid-Based Nanoparticle Protocol

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All lipids were purchased from Avanti Polar Lipids. See Supplemental Table 1 for a complete list of lipids and their associated catalog numbers. Hypromellose, N-methylpyrrolidone (NMP), and dodecyl isocyanate were purchased from Sigma Aldrich. Dialysis tubing was purchased from Spectrum Labs. Sterile PBS was purchased from Thermo Fisher. Tag-free and histidine tagged GFP were purchased from MilliporeSigma and Sino Biologicals, respectively. Mouse IgG1 isotype control antibody (clone MOPC-21) was purchased from Bio X Cell. Tag-free and histidine tagged human IL-12 were both purchased from Sino Biologicals.

Correa S., Grosskopf A.K., Klich J.H., Hernandez H.L, & Appel E.A. (2022). Injectable Liposome-based Supramolecular Hydrogels for the Programmable Release of Multiple Protein Drugs. Matter, 5(6), 1816-1838.

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Comprehensive Reagents and Materials for Research

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Polymer Coating of Polymeric Nanoparticles

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Hydroxypropylmethylcellulose (HPMC; MW ~ 90 kDa), dodecyl isocyanate, N,N-Diisopropylethylamine (DIPEA), acetone, and anhydrous N-methyl-2-pyrrolidone (NMP) were obtained from Sigma-Aldrich. PSNPs (50 nm diameter) were obtained from Phosphorex Inc. Phosphate-buffered saline without calcium or magnesium (PBS) was obtained from Corning.

Yu A.C., Lian H., Kong X., Lopez Hernandez H., Qin J, & Appel E.A. (2021). Physical networks from entropy-driven non-covalent interactions. Nature Communications, 12, 746.

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Synthesis of Benzimidazole Derivatives

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Imidazole (≥99.5%),
D₂O
(35 wt.% DCl), octyl isocyanate (97%), dodecyl isocyanate (99%), and
chloroform (99.0–99.4% GC) were purchased from Sigma-Aldrich.
Dimethyl sulfoxide (DMSO)-d₆ [99.8 atom
% D, contains 0.03% (v/v) tetramethylsilane (TMS)] was purchased from
VWR. Zinc nitrate hexahydrate (98%) was purchased from Alfa Aesar. N,N-Dimethylformamide (DMF) (99.5%), chloroform
(reagent grade), and dichloromethane stabilized with amylene (DCM)
(99.8%) were purchased from Fischer Scientific. 5-AminobenzImidazole
(>99%) was purchased from Santa Cruz Biotechnology. All materials
were used without further purification.

Bumstead A.M., Pakamorė I., Richards K.D., Thorne M.F., Boyadjieva S.S., Castillo-Blas C., McHugh L.N., Sapnik A.F., Keeble D.S., Keen D.A., Evans R.C., Forgan R.S, & Bennett T.D. (2022). Post-Synthetic Modification of a Metal–Organic Framework Glass. Chemistry of Materials, 34(5), 2187-2196.

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Synthesis of Dodecyl-Functionalized Hypromellose

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Hypromellose (1 g; Sigma Aldrich) was dissolved in anhydrous N‐methylpyrrolidone (NMP; 40 mL; Sigma Aldrich) and heated to 80 °C in a PEG bath. Dodecyl isocyanate (125 µL; Sigma Aldrich) was diluted in anhydrous NMP (5 mL) and added dropwise to the Hypromellose solution while rapidly stirring. N,N‐Diisopropylethylamine (HUNIGS; 10 drops; Sigma Aldrich) was added dropwise to the reaction solution while rapidly stirring. The heat bath was turned off, and the reaction was allowed to continue overnight while stirring. The polymer was precipitated in acetone (600 mL) and then dissolved in Millipore water (≈40 mL) prior to being dialyzed (3.5 kDa MWCO; Spectrum Labs) for 4 days. Pure HPMC‐C₁₂ was then lyophilized and dissolved in 1× PBS (Thermo Fisher) to produce a 6% w/v solution, which was stored at 4 °C until used.

Correa S., Meany E.L., Gale E.C., Klich J.H., Saouaf O.M., Mayer A.T., Xiao Z., Liong C.S., Brown R.A., Maikawa C.L., Grosskopf A.K., Mann J.L., Idoyaga J, & Appel E.A. (2022). Injectable Nanoparticle‐Based Hydrogels Enable the Safe and Effective Deployment of Immunostimulatory CD40 Agonist Antibodies. Advanced Science, 9(28), 2103677.

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Lipid-Based Nanoparticle Formulation Protocol

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All lipids were purchased from Avanti Polar Lipids. See Supplemental Table 1 for a complete list of lipids and their associated catalog numbers. Hypromellose, Nmethylpyrrolidone (NMP), and dodecyl isocyanate were purchased from Sigma Aldrich. Dialysis tubing was purchased from Spectrum Labs. Sterile PBS was purchased from Thermo Fisher. Tag-free and histidine tagged GFP were purchased from MilliporeSigma and Sino Biologicals, respectively. Mouse IgG1 isotype control antibody (clone MOPC-21) was purchased from Bio X Cell. Tag-free and histidine tagged human IL-12 were both purchased from Sino Biologicals.

Correa S., Grosskopf A.K., Klich J.H., Hernandez H.L., & Appel E.A. (2021). Injectable Liposome-based Supramolecular Hydrogels for the Programmable Release of Multiple Protein Drugs.

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