Chlorpromazine hcl

Manufactured by Merck Group

Sourced in United States, Japan

Chlorpromazine HCl is a chemical compound used as a pharmaceutical ingredient. It is a white or pale yellow crystalline powder. The chemical formula is C17H19ClN2S·HCl.

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Chlorpromazine (207 citations)

3 protocols using chlorpromazine hcl

Cell Culture and Treatment Protocols

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All cells were cultured at 37°C and 5% CO₂. HT1080 (human male), HEK293T/17 (human fetus), RKO (human, gender N/A), Lcells (mouse male), and WNT3A expressing Lcells (mouse male) were obtained from American Type Culture Collection (ATCC, Manassas, VA) and grown in DMEM with 10% FBS. Each cell line was tested for mycoplasma contamination and passaged no more than 20 passages from the original ATCC stock. Cells were treated at the indicated concentrations with the following compounds: CHIR99021 (Cayman Chemicals, Ann Arbor, MI), chlorpromazine HCL (Sigma-Aldrich, St. Louis, MO), bafilomycin A1 (Cayman Chemicals), rhWNT3A (PeproTech, Rocky Hill, NJ), rhWNT5A (R&D, Minneapolis, MN), neomycin trisulfate salt hydrate (Sigma-Aldrich) and carbachol (EMD Chemicals, Gibbstown, NJ).

Agajanian M.J., Walker M.P., Axtman A.D., Ruela-de-Sousa R.R., Serafin D.S., Rabinowitz A.D., Graham D.M., Ryan M.B., Tamir T., Nakamichi Y., Gammons M.V., Bennett J.M., Couñago R.M., Drewry D.H., Elkins J.M., Gileadi C., Gileadi O., Godoi P.H., Kapadia N., Müller S., Santiago A.S., Sorrell F.J., Wells C.I., Fedorov O., Willson T.M., Zuercher W.J, & Major M.B. (2019). WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop. Cell Reports, 26(1), 79-93.e8.

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Pharmacological Modulation of Rodent Behaviors

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Chlordiazepoxide HCl, pentobarbital Na, d-amphetamine SO₄, chlorpromazine HCl, clomipramine HCl, and isoproterenol HCl (Sigma Chemical Co., St. Louis, MO, USA), MDL100907 (Tocris Bioscience, Bristol, UK), and citalopram HBr (synthesized by Eli Lilly and Co., Indianapolis IN, USA). were dissolved in 0.9% NaCl. All compounds were prepared just prior to dosing and administered i.p. in a volume of 1 ml/kg body weight (mice) or 10 ml/kg body weight (rats). Fluoxetine was administered s.c. For marble burying, compounds were administered either 30 min, 15 min (pentobarbital), or 10 min (d-amphetamine) prior to behavioral testing. For nestlet shredding and locomotor acitivity, compounds were administered immediately prior to testing. Drug doses are expressed as the salt.

Rodriguez M.M., Overshiner C., Leander J.D., Li X., Morrow D., Conway R.G., Nelson D.L., Briner K, & Witkin J.M. (2017). Behavioral Effects of a Novel Benzofuranyl-Piperazine Serotonin-2C Receptor Agonist Suggest a Potential Therapeutic Application in the Treatment of Obsessive–Compulsive Disorder. Frontiers in Psychiatry, 8, 89.

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Evaluation of Phototoxic Chemicals

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Twenty phototoxic chemicals and 10 non-phototoxic chemicals were evaluated, including 6 drugs, 8 antimicrobials, 6 fragrances, 6 UV absorbers, and 4 other chemicals. Amiodarone HCl (1), anthracene (7), chlorpromazine HCl (9), 5-methoxypsoralen (15), 8-methox-ypsoralen (16), 6-methylcoumarin (17), ofloxacin (18) , hexachlorophene (21), ethylhexyl dimethyl p-aminobenzoate (23), chlorhexidine dihydrochloride (24), sodium lauryl sulfate (27), p-aminobenzoic acid (28), sulisobenzone (29), and lactic acid (30) were purchased from Sigma-Aldrich Japan (Tokyo, Japan). Rose bengal (2), bithionol (4), 3,3'4,5 tetrachlorosalicylanilide (5), fenofibrate (6), benzophenone (11), ketoprofen (13), methyl n-methylantranilate ( 14), and norfloxacin (19) were purchased from Wako Pure Chemical Industries (Osaka, Japan). 3,4',5-Tribromosalicylanilide (3), musk ambrette (8), promethazine (10), musk xylene (12), protoporphyrin IX, disodium (20), 2-octyl salicylate ( 22), 2-octyl methacrylate (25), and penicillin G (26) were purchased from Tokyo Chemical Industry (Tokyo, Japan).

Toyoda A., Sugiyama M., Furihata S., Nishizumi K., Omori T, & Itagaki H. (2017). Development of a modified 3T3 Neutral Red Uptake Phototoxicity Test protocol for evaluation of poorly water-soluble substances. The Journal of toxicological sciences, 42(5).

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