All patients underwent brain PET (2.44 mm slice thickness) and MRI (3.0 T, 1 mm thickness), including T1, T2, T3, fluid attenuated inversion recovery, and diffusion weighted imaging before surgery. CT of the brain (1 mm thickness) was performed using a Cosman–Roberts–Wells system or location markers on the day of the surgery. Data from the CT images were used to design the implantation of electrodes using a navigation and planning system (STEALTH Framelink, Medtronic, USA and Sinovation Medical Technology, Beijing, China).
Stealth framelink
Manufactured by Medtronic
Sourced in United States
The STEALTH Framelink is a medical device used for image-guided surgery. It provides a platform for integrating and aligning various surgical instruments and imaging technologies to assist healthcare professionals during procedures.
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Lab products found in correlation
2 protocols using stealth framelink
1
Pre-Surgical Brain Imaging and Planning
2
Simulation-Guided DBS Lead Optimization
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Anatomical references (anterior and posterior commissures) and participant imaging assembled in SCIRun software were used to perform finite element model (FEM) simulations for each subject. FEM simulations provided insight for optimal surgical targeting as well as postoperative stimulation titration, with FEM-predicted activation serving as an initial guide for therapeutic stimulation parameter selection. These models were constructed using a simple activation function (AF), calculated from the second derivative of stimulation voltage. Fiber tracts were "activated" when AF values within the fiber crossed a threshold, providing a percentage estimate of activation within the fiber bundle. Activated fibers can be "painted" within the SCIRun model to provide a spatial representation of stimulation, for the purpose of comparing alternative lead positions and stimulation settings. The results of these simulations were also used to produce activation histograms, depicting the percentage of activation within five designated fiber bundles of interest.
Outlines of ideal DBS lead locations and thalamic nuclei of interest were embedded in MRI volumes by setting those regions' voxels to maximum intensity, then exporting in DICOM format. These volumes were loaded into the surgical planning software (Stealth FrameLink, Medtronic) to facilitate final planning of lead trajectories.
Outlines of ideal DBS lead locations and thalamic nuclei of interest were embedded in MRI volumes by setting those regions' voxels to maximum intensity, then exporting in DICOM format. These volumes were loaded into the surgical planning software (Stealth FrameLink, Medtronic) to facilitate final planning of lead trajectories.
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