Acetylcholine bromide

Manufactured by Merck Group

Sourced in United States

Acetylcholine bromide is a chemical compound primarily used in research and laboratory settings. It is a salt of acetylcholine, a neurotransmitter that plays a crucial role in the functioning of the nervous system. Acetylcholine bromide is commonly utilized as a reagent in various experimental protocols, particularly in the study of neuroscience and related fields.

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Lab products found in correlation

5 protocols using acetylcholine bromide

Vasodilator and Vasoconstrictor Evaluation

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The following drugs were used: acetylcholine bromide, noradrenaline bitartrate,
sodium nitroprusside, N^G-nitro-L-arginine methyl ester, indomethacin (all
obtained from Sigma Chemical Co., St Louis, Missouri, USA). All drugs were dissolved
in Krebs-Henseleit solution.

Bruder-Nascimento T., Silva S.T., Boer P.A, & Cordellini S. (2015). Effects of exercise training on stress-induced vascular reactivity alterations: role of nitric oxide and prostanoids. Brazilian Journal of Physical Therapy, 19(3), 177-185.

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Vasopressor Signaling Pathway Modulation

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Drugs and suppliers were as follows: acetylcholine bromide (Sigma, St. Louis, MO, USA); adenosine (Sigma), angiotensin II amide; arginine vasopressin (AusPep, Parkville, Victoria, Australia); enalaprilat (gift from Merck, Rahway, New Jersey, USA); mecamylamine (Sigma); noradrenaline bitartrate (Sigma); and vasopressin V₁ receptor antagonist des-Gly-[Phe1,D-Tyr(Et)2,Lys6,Arg8]-vasopressin (Bachem, Bubendorf, Switzerland). All drugs used for in vivo assessment were prepared using sterile 0.9% sodium chloride solution. Angiotensin II was stored as a stock solution at -20 °C until required. All other drugs were made fresh daily.

Khammy M.M., Angus J.A, & Wright C.E. (2020). Estimation of the vascular resistance amplifier in the renal vascular bed in conscious hypertensive rabbits: comparison with the total peripheral vasculature. Heliyon, 6(4), e03810.

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Synthesis and Characterization of Nicotinic Compounds

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Acetylcholine bromide (CAS No. 66-23-9), (–)-nicotine free base (CAS No. 54-11-5), (–)-cotinine free base (CAS No. 486-56-6), and ( ±)-nornicotine (CAS No. 5746-86-1) were purchased from Sigma-Aldrich (St. Louis, MO, USA). ( +)-Anabasine hydrochloride (CAS No. 53912-89-3), buspirone hydrochloride (CAS No. 33386-08-2), and metanicotine oxalate (CAS No. 220662-95-3) were purchased from Tocris Bioscience (Bio-Techne^®, Minneapolis, MN, USA). ( ±)-Anatabine free base, AZD1446, and (S)-N-methylanatabine dihydrochloride were custom synthesized by WuXi AppTec (all: purity ≥ 95%; Shanghai, China).

Alzualde A., Jaka O., Latino D.A., Alijevic O., Iturria I., de Mendoza J.H., Pospisil P., Frentzel S., Peitsch M.C., Hoeng J, & Koshibu K. (2021). Effects of nicotinic acetylcholine receptor-activating alkaloids on anxiety-like behavior in zebrafish. Journal of Natural Medicines, 75(4), 926-941.

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Cardiovascular Pharmacology Protocols

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The following drugs were used: acetylcholine bromide, DMSA, enalapril maleate,
L-arginine, lead acetate, noradrenaline bitartrate, sodium nitroprusside, and
urethane (all obtained from Sigma Chemical Co., St Louis, Missouri, USA). All drugs
were dissolved in Krebs-Henseleit solution, and the concentrations were expressed in
molarity. Lead and sodium acetate were dissolved in acidified tap water as described
above. L-arginine and enalapril were dissolved in tap water. DMSA solutions were
freshly prepared by dissolving the compound in 5% NaHCO₃.

Gaspar A.F, & Cordellini S. (2014). Combination Therapy for the Cardiovascular Effects of Perinatal Lead Exposure in Young and Adult Rats. Arquivos Brasileiros de Cardiologia, 103(3), 219-230.

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Vasoreactivity Assessment Protocol

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Drugs used were acetylcholine bromide (Sigma, St Louis, MO, USA); ambrisentan (Selleckchem, Houston, TX, USA); bosentan sodium salt (Selleckchem); BQ788 sodium salt (Peptides International, Louisville, KY, USA); endothelin‐1 (Genscript, Piscataway, NJ, USA); macitentan (Selleckchem); N_ω‐nitro‐L‐arginine methyl ester hydrochloride (Sigma); (‐)‐noradrenaline bitartrate (Sigma); and sarafotoxin S6c (Auspep, Parkville, Victoria, Australia). All drugs were dissolved in MilliQ water except for endothelin‐1 which was dissolved in 10% dimethylformamide to 10⁻⁴ mol L⁻¹, then diluted in MilliQ water, macitentan which was dissolved in DMSO to 10⁻³ mol L⁻¹, then diluted in MilliQ water, and BQ788 which was dissolved in DMSO to 10⁻⁴ mol L⁻¹.

Angus J.A., Hughes R.J, & Wright C.E. (2017). Distortion of KB estimates of endothelin‐1 ETA and ETB receptor antagonists in pulmonary arteries: Possible role of an endothelin‐1 clearance mechanism. Pharmacology Research & Perspectives, 5(6), e00374.

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