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Luciferin potassium salt

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Luciferin potassium salt is a chemical compound commonly used in bioluminescence-based applications. Its core function is to serve as a substrate for luciferase enzymes, enabling the generation of luminescent signals. This product is widely utilized in various research and analytical settings where bioluminescence detection is required.

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Lab products found in correlation

Ivis spectrum, by PerkinElmer (1 mentions)

Spelling variants of this product

Luciferin (97 citations) D-luciferin potassium salt (62 citations) XenoLight D-Luciferin Potassium Salt (48 citations) XenoLight D-Luciferin Potassium Salt Bioluminescent Substrate (3 citations) IVISbrite™ D-Luciferin Potassium Salt (2 citations) IVISbrite D-Luciferin Potassium Salt Bioluminescent Substrate (2 citations) Xenolight D-Luciferin firefly potassium salt (2 citations) XenoLight potassium salt of D-luciferin (2 citations)

2 protocols using luciferin potassium salt

1

Bioluminescence Imaging in Mice

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Ten minutes after intravenous injection with 200 μl of luciferin potassium salt (PerkinElmer) suspended in PBS, mice were anesthetized and imaged using the IVIS Spectrum (PerkinElmer). Bioluminescence was quantified using Living Imaging software (Caliper Life Sciences).
May J.L., Kouri F.M., Hurley L.A., Liu J., Tommasini-Ghelfi S., Ji Y., Gao P., Calvert A.E., Lee A., Chandel N.S., Davuluri R.V., Horbinski C.M., Locasale J.W, & Stegh A.H. (2019). IDH3α regulates one-carbon metabolism in glioblastoma. Science Advances, 5(1), eaat0456.
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2

In Vivo Bioluminescence Imaging of Leukemia

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Mice implanted with Luciferase-tagged MV4;11 cells were peritoneally injected with luciferin potassium salt (PerkinElmer, cat#122799–5) at a dose of 150mg/kg before undergoing anesthesia with 3% isoflurane (Patterson Veterinary Supply, cat#07–806-3204) in air in anesthesia induction chamber. Bioluminescence imaging was performed using IVIS imaging system and mice were imaged approximately 5 minutes after substrate injection. Acquisition setting (binning and duration) were set up depending upon tumor activity at the time of acquisition.
Zhang M., Aguilar A., Xu S., Huang L., Chinnaswamy K., Sleger T., Wang B., Gross S., Nicolay B.N., Ronseaux S., Harvey K., Wang Y., McEachern D., Kirchhoff P., Liu Z., Stuckey J., Tron A.E., Liu T, & Wang S. (2021). Discovery of M-1121 as an orally active covalent inhibitor of menin-MLL interaction capable of achieving complete and long-lasting tumor regression. Journal of medicinal chemistry, 64(14), 10333-10349.
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