Lacosamide

Manufactured by Merck Group

Sourced in Germany, United States

Lacosamide is an anticonvulsant medication used to treat partial-onset seizures in adults. It is a white to off-white crystalline solid that is available in tablet and injection formulations.

Automatically generated - may contain errors

Lab products found in correlation

3 protocols using lacosamide

Analytical Reference Standards for Neuropharmaceuticals

Check if the same lab product or an alternative is used in the 5 most similar protocols

Reference standards for carbamazepine (purity 99%), phenytoin (certified reference material), clonazepam, lacosamide (certified reference material), phenobarbital (purity ≥ 95%), levetiracetam (purity ≥ 98%), lamotrigine (purity ≥ 98%), oxcarbazepine (purity ≥ 98%), clozapine (purity ≥ 98%), clobazam (purity ≥ 98%), valproic acid (purity ≥ 98%), and topiramate (purity ≥ 98%) were purchased from Sigma-Aldrich (Steinheim, Germany); methanol (LC–MS grade), ammonium acetate (purity ≥ 99.0%), and ammonium hydroxide solution (ACS reagent, 28.0–30.0% NH₃ basis) from Sigma-Aldrich (Riedel de Haёn, Germany); acetonitrile (LC–MS grade) from J.T. Baker (Avantor Performance Materials, Corporate Parkway Center Valley, PA, USA).

Shokry E., Marques J.G., Ragazzo P.C., Pereira N.Z, & Filho N.R. (2017). Earwax as an alternative specimen for forensic analysis. Forensic Toxicology, 35(2), 348-358.

+ Open protocol

+ Expand

Modulating Neuronal Ank3 Expression

Check if the same lab product or an alternative is used in the 5 most similar protocols

Mouse neuro-2a cells (ATCC, Manassas, VA) were dual transfected with the pHAGE-EF1α-dCas9-KRAB transcriptional repressor plasmid^{39 (link)} (Addgene) and sgRNA(MS2)-EF1α plasmid expressing Ank3-targeting or control sgRNA. For drug experiments, cells were treated for 1 h with the GSK3 inhibitors lithium (Sigma-Aldrich, St. Louis, Mo) or CHIR99021 (LC Laboratories, Woburn, Ma), or for 24 h with the CRMP2 inhibitor lacosamide (Sigma-Aldrich, St. Louis, Mo).

Garza J.C., Qi X., Gjeluci K., Leussis M.P., Basu H., Reis S.A., Zhao W.N., Piguel N.H., Penzes P., Haggarty S.J., Martens G.J., Poelmans G, & Petryshen T.L. (2018). Disruption of the psychiatric risk gene Ankyrin 3 enhances microtubule dynamics through GSK3/CRMP2 signaling. Translational Psychiatry, 8, 135.

+ Open protocol

+ Expand

Pharmacological Agents from Sigma-Aldrich

Check if the same lab product or an alternative is used in the 5 most similar protocols

Levomepromazine, haloperidol (antipsychotic), lacosamide, valproic acid, levetiracetam (antiepileptic), glatiramer acetate, fingolimod (immunomodulators), biperiden (antiparkinsonian) and dextromethorphan (cough treatment) were obtained from Sigma-Aldrich (Sigma, Saint Louis, Missouri, USA).

Doello K., Mesas C., Quiñonero F., Rama A.R., Vélez C., Perazzoli G, & Ortiz R. (2022). Antitumor Effect of Traditional Drugs for Neurological Disorders: Preliminary Studies in Neural Tumor Cell Lines. Neurotoxicity Research, 40(6), 1645-1652.

+ Open protocol

+ Expand

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Revolutionizing how scientists
search and build protocols!