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Tak 228

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TAK-228 is a laboratory reagent used for research purposes. It functions as a selective and potent inhibitor of the mammalian target of rapamycin (mTOR) kinase. The core function of TAK-228 is to modulate mTOR activity in experimental settings.

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Lab products found in correlation

Puromycin, by MedChemExpress (3 mentions) Temsirolimus, by Selleck Chemicals (3 mentions) Prexasertib, by Apexbio (3 mentions) Ve 822, by Thermo Fisher Scientific (3 mentions) Ly2603618, by Apexbio (3 mentions) Azd2014, by MedChemExpress (2 mentions) Mg132, by Selleck Chemicals (2 mentions) Azd1775, by MedChemExpress (2 mentions) Gemcitabine, by Selleck Chemicals (1 mentions) Torin2, by MedChemExpress (1 mentions) Olaparib, by MedChemExpress (1 mentions) U0126, by Apexbio (1 mentions) 4egi 1, by MedChemExpress (1 mentions)

3 protocols using tak 228

1

Chemical Compounds Utilized in Protocol

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Chemical compounds were purchased from Sigma (gemcitabine and temsirolimus), Selleckchem (prexasertib, LY2603618, U0126, and TAK-228), APExBio (VE-822), Thermo Fisher Scientific (puromycin), and MedChemExpress (Torin2, MK-8776, olaparib, and 4EGI-1).
Koppenhafer S.L., Goss K.L., Terry W.W, & Gordon D.J. (2018). mTORC1/2 and protein translation regulate levels of CHK1 and the sensitivity to CHK1 inhibitors in Ewing sarcoma cells. Molecular cancer therapeutics, 17(12), 2676-2688.
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2

Chemical Compound Acquisition Protocol

Check if the same lab product or an alternative is used in the 5 most similar protocols
Chemical compounds were purchased from Sigma (temsirolimus and MG132), Selleckchem (prexasertib, LY2603618, and TAK-228), APExBio (VE-822), Thermo Fisher Scientific (puromycin), and MedChemExpress (AZD1775, homoharringtonine, and AZD2014).
Goss K.L., Koppenhafer S.L., Waters T., Terry W.W., Wen K.K., Wu M., Ostergaard J., Gordon P.M, & Gordon D.J. (2020). The translational repressor 4E-BP1regulates RRM2 levels and functions as a tumor suppressor in Ewing Sarcoma Tumors. Oncogene, 40(3), 564-577.
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3

Chemical Compound Acquisition Protocol

Check if the same lab product or an alternative is used in the 5 most similar protocols
Chemical compounds were purchased from Sigma (temsirolimus and MG132), Selleckchem (prexasertib, LY2603618, and TAK-228), APExBio (VE-822), Thermo Fisher Scientific (puromycin), and MedChemExpress (AZD1775, homoharringtonine, and AZD2014).
Goss K.L., Koppenhafer S.L., Waters T., Terry W.W., Wen K.K., Wu M., Ostergaard J., Gordon P.M, & Gordon D.J. (2020). The translational repressor 4E-BP1regulates RRM2 levels and functions as a tumor suppressor in Ewing Sarcoma Tumors. Oncogene, 40(3), 564-577.
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