Myovation software

Perfusion SPECT and FDG-PET which were performed on the same day were evaluated simultaneously on the consensus of two independent nuclear medicine physicians. Static tomographic images and polar maps were normalized to their maximum and used for visual analysis of regional perfusion/metabolism patterns using the American Heart Association 17-segment model. The perfusion defect area was quantified on polar maps according to a method described previously [2 (link)].Visual classification was performed for normal, matched defect, or mismatch segments. Segments with decreased uptake on perfusion SPECT were visually defined as matched defect segments if FDG uptake was consistent with the decrease on PET. Segments with decreased uptake on perfusion SPECT were defined as mismatched segments if FDG uptake was not consistent with the decrease on PET. SPECT and FDG-PET analysis was managed by Myovation software (GE Medical system, Milwaukee, WI, USA).

After Tc-99m sestamibi myocardial perfusion SPECT, ¹⁸F-FDG cardiac PET/CT (FDG-PET) was performed. Imaging was performed on a Discovery PET/CT Elite (Discovery NM 690; GE medical system, Milwaukee, WI, USA). Preparation was performed using simplified glucose/insulin loading (20 g dextrose intravenously with simultaneous and subcutaneous insulin to adjust blood glucose to 5 mmol/l [17 (link), 23 (link)]). PET/CT acquisitions for the heart were started at 40 min after the injection of ¹⁸F-FDG 74–111 MBq/pig. CT images were acquired using parameters with a peak voltage of 140 keV, a tube current of 20 mA × 16 s, a rotation time of 1.0 s, a field of view of 50 cm, and slice thickness of 3.75 mm. Immediately following the CT acquisition, the PET data were acquired in the same anatomic locations in the 2D mode with acquisition times of 10 min. The CT data were used for attenuation correction and the images were reconstructed using a conventional iterative algorithm (OSEM). A Xeleris workstation with Myovation software (GE medical system, Milwaukee, WI, USA) providing multiplanar reformatted images was used for image display and analysis.