Cobas u411 urine analyzer

Manufactured by Roche

Sourced in Germany

The Cobas U411 is a urine analyzer designed for automated processing and analysis of urine samples. It provides quantitative measurement of various urine parameters to support clinical diagnostic testing.

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Lab products found in correlation

Combur 10 urine sticks, by Roche (2 mentions) 200fr neo chemistry analyzer, by Toshiba (1 mentions) Clinitek advantus, by Siemens (1 mentions) Multistix 10 sg, by Siemens (1 mentions) Combi 514r, by Hanil (1 mentions) Acl 8000, by Beckman Coulter (1 mentions) Cobas c501 chemistry analyzer, by Roche (1 mentions) Advia 120, by Siemens (1 mentions) Cobas c501, by Roche (1 mentions) Combur10test m stick, by Roche (1 mentions)

7 protocols using cobas u411 urine analyzer

Comprehensive Urine Analysis Protocol

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Urine samples were collected overnight (approximately 16 h) using a cage pan, once during the acclimation period, on days 31 and 59. Animals were not fasted prior to blood collection. The collected urine samples were centrifuged (1500 rpm, 5 min at room temperature) for urine chemistry and urine sediment analysis. Urinalysis parameters were measured by reading the scales on the urine collection tubes of Combur 10 TM urine sticks (Roche) and Cobas U411 urine analyzer (Roche) and then examined visually or under a microscope. These parameters included volume (VOL), color (COL)/clarity (CLA), pH, specific gravity (SG), bilirubin (BILU), protein (PRO), urobilinogen (UBG), nitrite (NIT), glucose (GLUU), erythrocytes (ERY), ketones (KETU), leukocytes (LEU), and urine sediments (urine cast, epithelial cells, white blood cells, and red blood cells). Urine potassium (UK), chloride (UCl), and sodium (Una) levels were measured using a Toshiba 2000FR NEO chemistry analyzer.

Oh S., Jang M.S., Jung K.J., Han J.S., Lee H., Gil A., Jeon B., Roberts C.C., Maslow J.N., Kim Y.B, & Han K.H. (2023). Preclinical safety assessment of the suction-assisted intradermal injection of the SARS-CoV-2 DNA vaccine candidate pGO-1002 in white rabbit. Archives of Toxicology, 97(4), 1177-1189.

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Comprehensive Urine Analysis Protocol

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Before termination, urine was collected overnight using metabolic cages. Food was withdrawn, but water was supplied. Volume, color, clarity, pH, specific gravity, urobilinogen, bilirubin, protein, nitrite, glucose, ketone, and erythrocyte levels were analyzed with a Cobas U411 urine analyzer and Combur 10 urine sticks (Roche, Germany). Moreover, microscopic examination was conducted for epithelial cell, red blood cell, white blood cell, and urine cast.

Noh J.H., Jeong J.S., Park S.J., Yun E.Y., Hwang J.S., Kim J.Y., Jung K.J., Park H.J., Son H.Y, & Moon K.S. (2018). Toxicological safety evaluation of freeze-dried Protaetia brevitarsis larva powder. Toxicology Reports, 5, 695-703.

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Comprehensive Urinalysis in Animal Study

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Animals were fasted overnight prior to urine collection. Urine samples were collected with a clean cage pan on wet ice (first void in the morning of each collection day), and the total fresh urine volume (VOL) was recorded. Urine samples were collected in a urine specimen container and kept cool with wet ice before analysis. Urinalysis was performed using a COBAS U 411 urine analyzer (Roche, Germany) and Combur 10 TM urine stick (Roche, Germany) to determine the following parameters: color, specific gravity (SG), pH, urine total protein (UTP), urine glucose (UGLU), urine creatinine (UCRE), urine albumin (UALB), and urine protein to creatinine ratio (P/C). Urine potassium (U-K), urine chlorine (U-Cl), and urine sodium (U-Na) were measured using a Toshiba 200FR NEO chemistry analyzer (Toshiba Co., Japan).

Park H.K., Cho J.W., Lee B.S., Park H., Han J.S., Yang M.J., Im W.J., Park D.Y., Kim W.J., Han S.C, & Kim Y.B. (2016). Reference values of clinical pathology parameters in cynomolgus monkeys (Macaca fascicularis) used in preclinical studies. Laboratory Animal Research, 32(2), 79-86.

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Comprehensive Urinalysis Protocol for Animal Studies

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In the last week of observation, 5 animals/sex/dose were individually housed in metabolic cages. About 1 mL of fresh urine samples were taken for analysis. The urine was collected for 24 h to obtain the total urine volume for each animal. Urine test strips (Multistix 10SG, Siemens, Munchen, Germany) were dipped in approximately 0.3 mL samples of urine, and the following parameters were analyzed using an automatic analyzer (Clinitek Advantus, Siemens, Munchen, Germany): bilirubin (BIL), pH, nitrite (NIT), ketone body (KET), protein (PRO), occult blood (BLO), glucose (GLU), specific gravity, and urobilinogen (URO). Urine color was observed by naked eye in the animal room, and the results were manually input into the automatic analyzer (COBAS U411 Urine Analyzer; Roche Diagnostics, Mannheim, Germany). For the urine sediment test, the remaining urine sample after general examination was centrifuged at 33× g (Combi-514R; Hanil, Gimpo, Korea) for 5 min. The sediments were stained using Sternheimer-Malbin method, and the following parameters were evaluated using a microscope: WBC, epithelial cell, RBC counts, and cast.

Kim S.Y., Kwak K.W., Park E.S., Yoon H.J., Kim Y.S., Park K., Kim E, & Kim S.D. (2020). Evaluation of Subchronic Oral Dose Toxicity of Freeze-Dried Skimmed Powder of Zophobas atratus Larvae (frpfdZAL) in Rats. Foods, 9(8), 995.

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Comprehensive Clinical Pathology Assessment

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Blood samples for clinical pathology assessment (hematology, clinical chemistry, and coagulation) were collected pre-test (Day −3) and, for one or more dose groups on Days 22, 55, 85, 106, 134, 160, 176, and 189. When possible, clinical pathology specimens were collected prior to unscheduled euthanasia for moribund animals. All clinical pathology blood samples were collected from a jugular vein. Standard hematological (Advia 120, Siemens, Germany), clinical chemistry (Cobas c 501, Roche, Switzerland), and coagulation parameters (ACL 8000, Beckman Coulter, USA) were analyzed. Urine analysis (Roche Cobas u 411 urine analyzer) and urine chemistry (Roche Cobas c 501 chemistry analyzer) were performed on urine specimens collected overnight pre-test and during Weeks 4, 13, 16 (Group 3 males only), 20 (Group 3 males only), 23, and 27. For the list of analytes evaluated see Supplementary Tables S2–S6.

Wallery J.J., Kale V.P., Novak J., Gibbs S., Do M.H., McKew J.C, & Terse P.S. (2021). Evaluation of chronic toxicity of cyclocreatine in beagle dogs after oral gavage administration for up to 23 weeks. Toxicology and applied pharmacology, 430, 115680.

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Urinary Biomarker Evaluation in Rats

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On day 90, fresh urine was collected for 3 h from 5 rats of each sex per group in the fasting state, and a 21-h urine sample was subsequently collected while allowing access to food. Rats in metabolic cages (Biotoxtech, Cheongju, Republic of Korea) were allowed free access to water during both urine collection periods. The urine samples were stored at4°C until analysis was performed within 2 h of sample collection. The Combur¹⁰Test^®M stick (Roche Diagnostics, Mannheim, Germany) was used to measure pH, protein, glucose, and occult blood, while urine chemistry was done with a Cobas u 411 urine analyzer (F. Hoffmann-La Roche, Basel, Swizerland). Urine color and turbidity were checked by visual inspection. The 24-h urine was used for measurement of the urine volume and specific gravity. The specific gravity was measured with a Gravimeter (VET 360, Reichert Technologies, New York, USA).

Moon S.H., Kim D., Shimizu N., Okada T., Hitoe S, & Shimoda H. (2016). Ninety-day oral toxicity study of rice-derived γ-oryzanol in Sprague-Dawley rats. Toxicology Reports, 4, 9-18.

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Comprehensive Urinalysis Protocol

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Urine samples were collected at approximately 3–4 h within 1 week prior to necropsy. The following parameters were measured during urinalysis: color, clarity, glucose, pH, erythrocyte, specific gravity, ketone, bilirubin, leukocytes, protein, nitrite, and urobilinogen. All parameters except for urine color were analyzed using Combur 10 TM urine sticks (Roche, Germany) and a Cobas U411 urine analyzer (Roche, Germany).

Park S.J., Yoon H.J., Gu E.Y., Lee B.S., Kim Y., Jung J., Kim J, & Moon K.S. (2022). A general toxicity and biodistribution study of human natural killer cells by single or repeated intravenous dose in severe combined immune deficient mice. Toxicological Research, 38(4), 545-555.

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