Unlabeled folic acid

Manufactured by Merck Group

Unlabeled folic acid is a chemical compound that is a vital nutrient required for various biological processes in the body. It plays a crucial role in the production and maintenance of healthy cells, particularly in the development of red blood cells and the proper functioning of the nervous system. This product is a lab-grade material intended for research and analytical purposes, and its specific applications may vary depending on the research objectives.

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Lab products found in correlation

14c u glycine, by Moravek Biochemicals (5 mentions) Folic acid, by Moravek Biochemicals (4 mentions)

Close spelling variants of this product

Folic acid (313 citations)

5 protocols using unlabeled folic acid

Antifolate Drugs Synthesis and Characterization

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[¹⁴C(U)]Glycine (87 mCi/mmol) was purchased from Moravek Biochemicals (Brea, CA). Unlabeled folic acid was purchased from the Sigma Chemical Co. (St. Louis, MO). Leucovorin [(6R,S) 5-formyl tetrahydrofolate] was provided by the Drug Development Branch, National Cancer Institute, Bethesda, MD. The sources of the classical antifolate drugs were as follows: MTX, Drug Development Branch, National Cancer Institute (Bethesda, MD); RTX [N-(5-[N-(3,4-dihydro-2-methyl-4-oxyquinazolin-6-ylmethyl)-N-methyl-amino]-2-thienoyl)- l-glutamic acid], AstraZeneca Pharmaceuticals (Maccesfield, Cheshire, England); and PMX [N-{4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}- l-glutamic acid] (Alimta) (LC Laboratories, Woburn, MA). Other chemicals were obtained from commercial sources in the highest available purity.

Xiang W., Dekhne A., Doshi A., O’Connor C., Hou Z., Matherly L.H, & Gangjee A. (2019). Discovery of amide-bridged pyrrolo[2,3-d]pyrimidines as tumor targeted classical antifolates with selective uptake by folate receptor α and inhibition of de novo purine nucleotide biosynthesis. Bioorganic & medicinal chemistry, 27(23), 115125.

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Radiolabeled Antifolate Drug Acquisition

Cited 1 time

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[3′, 5′, 7, 9-³H]Folic acid (25 Ci/mmol), [3′, 5′, 7-³H]MTX (20 Ci/mmol), and [¹⁴C(U)]-glycine (87mCi/mmol) were purchased from Moravek Biochemicals (Brea, CA). Unlabeled Folic acid was purchased from the Sigma-Aldrich (St. Louis, MO). LCV [(6R,S)5-formyl tetrahydrofolate] was provided by the Drug Development Branch, National Cancer Institute (Bethesda, MD). The sources of the classical antifolate drugs were as follows: MTX, Drug Development Branch, National Cancer Institute; LMTX (5,10-dideaza-5,6,7,8- tetrahydrofolate) and PMX [N-{4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5- yl)ethyl]benzoyl}-L-glutamic acid] (Alimta), Eli Lilly and Co. (Indianapolis, IN); RTX [N-(5-[N-(3,4- dihydro-2-methyl-4-oxyquinazolin-6-ylmethyl)-N-methyl-amino]-2-thienoyl)-L-glutamic acid], AstraZeneca Pharmaceuticals (Maccesfield, Cheshire, England); and PT523 [N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithine],^{30 (link)} A. Rosowsky (Boston, MA). Other chemicals were obtained from commercial sources in the highest available purities.

Golani L.K., Wallace-Povirk A., Deis S.M., Wong J.E., Ke J., Gu X., Raghavan S., Wilson M.R., Li X., Polin L., de Waal P.W., White K., Kushner J., O’Connor C., Hou Z., Xu H.E., Melcher K., Dann CE I.I.I., Matherly L.H, & Gangjee A. (2016). Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions Via Cellular Uptake by Folate Receptor α and the Proton-coupled Folate Transporter and Inhibition of De Novo Purine Nucleotide Biosynthesis. Journal of medicinal chemistry, 59(17), 7856-7876.

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Radiolabeled Folate Compounds Analysis

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[3′,5′,7,9-³H]Folic acid (25 Ci/ mmol), [3′,5′,7-³H]MTX (20 Ci/mmol), [³H]PMX (1.3 Ci/mmol), and [¹⁴C(U)]-glycine (87mCi/mmol) were purchased from Moravek Biochemicals (Brea, CA). [³H]7 (12.3 Ci/mmol) was custom radiolabeled by Moravek Biochemicals. Unlabeled Folic acid was purchased from the Sigma Chemical Co. (St. Louis, MO). LCV [(6R,S)5-formyl tetrahydrofolate] was provided by the Drug Development Branch, National Cancer Institute, Bethesda, MD. The sources of the classical antifolate drugs were as follows: MTX, Drug Development Branch, National Cancer Institute (Bethesda, MD); PDX [N-(4-{1-[(2,4-diaminopteridin-6-yl)methyl]but-3-yn-1-yl}-benzoyl)-L-glutamic acid], Allos Therapeutics (Westminster, CO); and PMX [(4-(2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]-pyrimidin-5-yl)ethyl)benzoyl)-L-glutamic acid] (Alimta), Eli Lilly and Co. (Indianapolis, IN). Other chemicals were obtained from commercial sources in the highest available purity.

Wang L., Wallace A., Raghavan S., Deis S.M., Wilson M.R., Yang S., Polin L., White K., Kushner J., Orr S., George C., O’Connor C., Hou Z., Mitchell-Ryan S., Dann CE I.I.I., Matherly L.H, & Gangjee A. (2015). 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors. Journal of medicinal chemistry, 58(17), 6938-6959.

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Radiolabeled Antifolate Drug Synthesis and Characterization

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[3′,5′,7,9-³H]Folic acid (25 Ci/mmol), [3′,5′,7-³H]MTX (20 Ci/mmol), and [¹⁴C(U)]glycine (87mCi/mmol) were purchased from Moravek Biochemicals (Brea, CA). Unlabeled Folic acid was purchased from Sigma Chemical Co. (St. Louis, MO). Leucovorin [(6R,S) 5-formyl tetrahydrofolate] (LCV) was obtained from the Drug Development Branch, National Cancer Institute, Bethesda, MD. The sources of the classical antifolate drugs were as follows: MTX, Drug Development Branch, National Cancer Institute (Bethesda, MD); RTX [N-(5-[N-(3,4-dihydro-2-methyl-4-oxyquinazolin-6-ylmethyl)-N-methyl-amino]-2-thienoyl)-L-glutamic acid], AstraZeneca Pharmaceuticals (Maccesfield, Cheshire, England); PMX [N-{4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo-[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamic acid] (Alimta), Eli Lilly and Co. (Indianapolis, IN); and PTX ((2S)-2-[[4-[(1RS)-1-[(2, 4-diaminopteridin-6-yl)methyl]but-3-ynyl]benzoyl]amino]-pentanedioic acid), Allos Therapeutics (Henderson,NV); and (PT523) [Nα-(4-amino-4-deoxypteroyl)-Nδ-hemiphthaloyl-L-ornithine], Dr. Andre Rosowsky (Boston, MA). Other chemicals were obtained from commercial sources in the highest available purity.

Ravindra M., Wallace-Povirk A., Karim M.A., Wilson M.R., O’Connor C., White K., Kushner J., Polin L., George C., Hou Z., Matherly L.H, & Gangjee A. (2018). Tumor Targeting with Novel Pyridyl 6-Substituted Pyrrolo[2,3-d]Pyrimidine Antifolates via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of De novo Purine Nucleotide Biosynthesis. Journal of medicinal chemistry, 61(5), 2027-2040.

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Radiolabeled Folate Analogs Protocol

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[3′,5′,7–³H]MTX (20 Ci/mmol), [3′, 5′, 7, 9–³H]folic acid (25 Ci/mmol), and [¹⁴C(U)]glycine (87 mCi/mmol) were purchased from Moravek Biochemicals (Brea, CA). Unlabeled folic acid was purchased from Sigma-Aldrich (St. Louis, MO). LCV [(6R,S)5-formyl tetrahydrofolate] and MTX were provided by the Drug Development Branch, National Cancer Institute (Bethesda, MD). PMX [N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid] (Alimta) was provided by Eli Lilly and Co. (Indianapolis, IN). PT523 [Nα-(4-amino-4-deoxypteroyl)-Nδ-hemiphthaloyl-L-ornithine] was a gift from A. Rosowsky (Boston, MA). Other chemicals were obtained from commercial sources in the highest available purities.

Ravindra M., Wilson M.R., Tong N., O’Connor C., Karim M., Polin L., Wallace-Povirk A., White K., Kushner J., Hou Z., Matherly L.H, & Gangjee A. (2018). Fluorine-Substituted Pyrrolo[2,3-d]Pyrimidine Analogues with Tumor Targeting via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis. Journal of medicinal chemistry, 61(9), 4228-4248.

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