The MCXCL12 1α is a laboratory equipment product. It functions as a chemical reagent for research purposes.
Example 8
To investigate the effects of the dose of the mCXCL12 1α administered to the wound surface 0.2 μg, 0.6 μg or 1 μg mCXCL12 1α (RnD Systems) was delivered to the wounds daily for two days in 10 μl saline. The administration was once per day.
Delivery of the mCXCL12 1α daily at one single time point per day did not accelerate wound healing for the first two days as compared to no treatment (
Example 8
To investigate the effects of the dose of the mCXCL12 1α administered to the wound surface 0.2 μg, 0.6 μg or 1 μg mCXCL12 1α (RnD Systems) was delivered to the wounds daily for two days in 10 μl saline. The administration was once per day.
Delivery of the mCXCL12 1α daily at one single time point per day did not accelerate wound healing for the first two days as compared to no treatment (
Example 8
To investigate the effects of the dose of the mCXCL12 1α administered to the wound surface 0.2 μg, 0.6 μg or 1 μg mCXCL12 1α (RnD Systems) was delivered to the wounds daily for two days in 10 μl saline. The administration was once per day.
Delivery of the mCXCL12 1α daily at one single time point per day did not accelerate wound healing for the first two days as compared to no treatment (
Example 16
To show that the mode of delivery and continuous protein production enabled by the lactic acid bacteria is important for the mechanism, murine recombinant mCXCL12 1α, mCXCL17, mYm1 (total of 200 ng in 60 μl, all RnD Systems) or saline (10 μl) as control was delivered to the wound once daily every 10th minute for one hour.
For mCXCL12 1α, delivery of 30 ng into the peritoneal cavity induces significantly increased recruitment of immune cells in 3 hours, why 200 ng to an area of 25 μm2 is to be considered a high dose.
It is likely that the high protease activity in the wound degrades the chemokines when given as recombinant protein at one single time point, and thus the de novo production by the bacteria is required for the protein to enhance wound closure. In addition, the lactic acid bacteria might also provide a beneficial local environment for wound healing (
Example 16
To show that the mode of delivery and continuous protein production enabled by the lactic acid bacteria is important for the mechanism, murine recombinant mCXCL12 1α, mCXCL17, mYm1 (total of 200 ng in 60 μl, all RnD Systems) or saline (10 μl) as control was delivered to the wound once daily every 10th minute for one hour.
For mCXCL12 1α, delivery of 30 ng into the peritoneal cavity induces significantly increased recruitment of immune cells in 3 hours, why 200 ng to an area of 25 μm2 is to be considered a high dose.
It is likely that the high protease activity in the wound degrades the chemokines when given as recombinant protein at one single time point, and thus the de novo production by the bacteria is required for the protein to enhance wound closure. In addition, the lactic acid bacteria might also provide a beneficial local environment for wound healing (
Example 16
To show that the mode of delivery and continuous protein production enabled by the lactic acid bacteria is important for the mechanism, murine recombinant mCXCL12 1α, mCXCL17, mYm1 (total of 200 ng in 60 μl, all RnD Systems) or saline (10 μl) as control was delivered to the wound once daily every 10th minute for one hour.
For mCXCL12 1α, delivery of 30 ng into the peritoneal cavity induces significantly increased recruitment of immune cells in 3 hours, why 200 ng to an area of 25 μm2 is to be considered a high dose.
It is likely that the high protease activity in the wound degrades the chemokines when given as recombinant protein at one single time point, and thus the de novo production by the bacteria is required for the protein to enhance wound closure. In addition, the lactic acid bacteria might also provide a beneficial local environment for wound healing (
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