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Lightspeed rt

Manufactured by GE Healthcare
Sourced in United Kingdom, United States

The LightSpeed RT is a computed tomography (CT) imaging system developed by GE Healthcare. It is designed to provide high-quality images for a variety of clinical applications. The system utilizes advanced technology to enable rapid image acquisition and reconstruction.

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13 protocols using lightspeed rt

1

Enhanced CT Imaging of Lesion Delineation

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Enhanced CT was performed in all patients. A large-aperture spiral CT scanner (Light SpeedRT, GE) was used for axial scanning. The scanning range was from the cranial vault to the subclavian plane. The CT scanning parameters were: tube voltage 140 kV; tube current 380 mA; image resolution 512*512; and layer thickness 2.5 mm. 70mL of iodixanol was injected into the vein at a rate of 2.0 mL/s. Patients were scanned and the images were saved after 50 seconds. The CT scan images were then transferred to the MIM planning system (MIM Software Inc.) in DICOM format. Images with substantial CT artifacts were excluded to avoid confounding on subsequent feature extraction and analysis. ROI was manually outlined layer by layer on post-contrast CT images by an experienced radiologist using the MIM planning system, and confirmed by a senior radiologist. Another radiologist outlined the ROI of 50 randomly selected patients for subsequent calculation of the interclass correlation coefficient (ICC). The outline principles were described in the International Commission on the International Commission on Radiation Units (ICRU) and Measurements Reports 50 and 62. The lesion area was confirmed using MRI in order to match the lesion margins as closely as possible.
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2

3D-Printed PLA Sample Characterization

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Seven white PLA sample blocks of dimensions 5x5x1 cm, printed at 100% infill, were acquired from three local commercial 3D‐printing services, denoted Service A, B and C. All manufacturers had no prior production of radiotherapy services at the time of the study. Services A and C produced two 3D‐printed samples each and Service B produced three samples. All services used a MakerBot 3D‐printer for sample production. The authors did not participate in the printing process. For each sample, average length, width, and thickness were determined from vernier calliper measurements at multiple positions. Sample weight, from a calibrated scale, was used to determine physical density (g cm−3). Production time was not considered in this study.
Samples were CT scanned (GE LightSpeedRT, 120 kVp, 1.25 mm slice width) pressed between 5 cm thick solid water slabs to avoid reconstruction artefacts near sharp corners. Observable internal structure variations were noted, and average Hounsfield unit (HU) values calculated from a volume covering the sample excluding the superficial 1 mm region in all dimensions, to avoid partial voxel resolution blurring with the outside air/slab HU.
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3

3DCRT for Prostate Cancer Patients

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Nineteen prostate cancer patients treated between April 2011 and August 2012 with 3DCRT were retrospectively studied. The retrospective analysis was conducted in accordance with the Helsinki declaration, and the study protocol was approved by the medical ethics committee of Kushiro City General Hospital. Patient information was anonymized and de-identified prior to analysis. The tumor clinical stages were as follows: T1, 7 patients; T2, 8 patients; and T3, 4 patients. Eleven patients underwent hormonal therapy before 3DCRT (median duration: 6 months, range: 3–21). All patients were prescribed a dose of 70 Gy in 35 fractions over 50–55 days. They were instructed to empty the rectum and drink 250 ml of water 30 min before the planning CT (LightSpeed RT, GE Healthcare Ltd, Little Chalfont, Buckinghamshire, HP7 9NA, United Kingdom) and treatment delivery for bladder filling. The CBCT images were acquired once every five fractions for a total of 7 datasets per patient. The planning CT and CBCT images were reconstructed using a 2.5-mm slice thickness and a 2.5-mm increment. A single observer contoured the prostate on all CBCT images.
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4

Immobilization and CT Scanning Protocol for Radiotherapy

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Each patient was immobilized using a thermoplastic mask (CIVCO Co., Orange City, IA, USA) and a mouthpiece composed of an ethylene–vinyl acetate copolymer (Erkodent Erich Kopp GmbH, Pfalzgrafenweiler, Germany). Then, a radiotherapy treatment planning CT scan was conducted using a 16-slice CT scanner (Lightspeed RT, General Electric Medical Systems, Waukesha, WI, USA) with the following parameters: tube voltage, 120 kVp; tube current, auto-exposure control; slice thickness, 1.25 mm; and field of view, 50 cm. All CT image data were reconstructed with a thickness of 2.5 mm.
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5

CT Imaging with Respiratory Gating

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All of the patients underwent CT scanning (GE Lightspeed RT) in the supine position and were immobilized in an upper body cradle with their arms overhead. During the CT image acquisition, patient respiration was monitored with an external respiratory gating system (Active Breathing Coordinator™ R2.0; Elekta). The CT data were then imported into the planning system (Pinnacle, version 7.0, Philips).
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6

Evaluating PACM-Iodixanol Dye Stability

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To verify the homogeneity and stability of PACM and radio-opaque iodixanol dye (Visipaque, GE Health Care, Korea), we made six mixtures of 1 L of PACM and 2.0ⅹ10−3 L of radio-opaque dye and placed them in six 1.0ⅹ10−3 m3 containers. We performed CT scans (Lightspeed RT, GE Healthcare, USA) of the containers and recorded Hounsfield units at 27 equidistant spots (Fig 1) in each container. After scanning, three containers were kept at room temperature (22°C), and the other three containers were maintained at body temperature (37°C) for 24 hours. After this time period, new CT scans of all six containers were obtained, and Hounsfield units were compared with those previously measured.
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7

4D-CT Imaging and Respiratory Motion Analysis

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The 4D-CT images were obtained using LightSpeed RT (GE Healthcare, Waukesha, WI, USA) with RPM system. We placed the infrared marker for RPM systems on the patients’ xiphoid and asked the patients breathe freely and regularly. The 4D-CT images with phase information were sorted and reconstructed by Advantage Workstation (GE Healthcare).
Phases were sorted as 40%–60%, 30%–70%, and 0%–90% (all phases) from 4D-CT images and reconstructed as MIP and Min-IP methods, respectively. The phase of 40%–60% is routinely used to minimize the residual motion in our department and the phase of 30%–70% is used when the patients’ respirations are not stable. Six types of reconstructed images were acquired for each case in Table 1.
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8

3D Printed Needle Insertion Phantom Validation

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To mimic the needle insertion more closely during clinical surgery, a 3D printing technology based in‐laboratory validation phantom was devised with 20 18‐gauge brachyneedles (made in Hakko Co., Ltd, Nagano, Japan) in known orientations and endpoints. The 115 mm × 60 mm × 110 mm plate and a matrix of holes was directly formed through a digital 3D printer (made in Aurora Technology Co., Ltd, Shenzhen, China with machine error 0.05 mm). In the matrix of holes, various of insertion angle θ varying from 0° to 60° in 15° step with different insertion depth h = 40, 60, 80, and 100 mm were planned to test the robustness of our algorithm (as shown in Fig. 6). The validation experiment was carried out at The Second Hospital of Tianjin Medical University, 15 CT image slices of the phantom were obtained from a spiral CT system (GE LightSpeed RT) with the parameters were set to 100 kV and 150 mA. The size of the physical phantom image was 512 × 512 × Z, where Z ranged from 4 to 12 slices with a voxel resolution of 0.70 × 0.70 × 5 mm3.
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9

IMRT Prostate Cancer Treatment Protocol

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Three fiducial 2.0‐mm gold markers were implanted in the prostate of each patient, under rectal ultrasound guidance. Approximately 1 month after the implantation, the patient was immobilized in a VacLok™ bag (Med‐Tech, Orange City, IA, USA) in the supine position and scanned on a 16‐slice CT scanner (Lightspeed RT, General Electric Medical Systems, Waukesha, WI, USA) with a filled bladder and no special bowel preparation. Planning CT images were obtained with 1.25‐mm‐thick axial slices. The prostate, seminal vesicles (SV), fiducial markers, rectum wall, and bladder wall were contoured using the Eclipse treatment planning system ver. 8.9.17 (Varian Medical Systems, Palo Alto, CA, USA). A clinical target volume (CTV) was contoured as the sum of the prostate and the proximal one‐third of the SV. The margin of the CTV to the planning target volume (PTV) was 6 mm in the left‐right (LR), anterior, and superior directions and 5 mm in the posterior and inferior directions. A seven‐field IMRT plan was generated with 6‐MV photon beams using an anisotropic analytic algorithm and the sliding window technique.
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10

Immobilization and Contouring Protocol for Prostate Radiotherapy

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Patients were immobilized in the prone position with a thermoplastic shell (Hip Fix system; CIVCO Medical Solutions, Kalona, IA, USA) that extended from the mid-thigh to the upper third of the leg, in combination with a vacuum pillow (Vac-Lok system; CIVCO Medical Solutions) and a leg support. Each patient underwent pretreatment planning CT scans (LightSpeed RT; GE Healthcare, Little Chalfont, UK) of 2.5 mm slice thickness. All patients were instructed to void the bladder and rectum ~1–1.5 h before the CT simulation, according to their individual urinary conditions.
The prostate, seminal vesicles (SVs), rectum and bladder were manually contoured by several experienced radiation oncologists and medical physicists. The rectum was determined as the area from 15 mm below the prostate apex to 15 mm above the tips of the SVs or prostate base. Details of our contouring protocol have been reported previously [15 (link)].
The contours of the prostate, SVs, rectum and bladder on planning CT images were converted to polygon (PLY) file format using a commercially available system [ITEM’s Viewer planning and Assistant System (iVAS); ITEM Corporation, Osaka, Japan].
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