Six‐ to eight‐week‐old heterozygous mice were fed with chow containing PLX5622 (1,200 parts per million [ppm] formulated in AIN‐76A standard rodent diet; Research Diets Inc., New Brunswick, NJ) or identical chow without drug for control animals.
Ain 76a standard rodent diet
Manufactured by Research Diets
Sourced in United States
AIN‐76A is a standard rodent diet formulated for use in laboratory research. It is designed to provide complete and balanced nutrition for rodents. The diet is grain-based and contains defined amounts of protein, carbohydrates, fats, vitamins, and minerals.
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Lab products found in correlation
2 protocols using ain 76a standard rodent diet
1
Modulation of Microglial Activation
2
Microglia Depletion and LPS Challenge
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The CSF-1R inhibitor PLX5622 was incorporated into the mouse chow (1200 ppm formulated in AIN-76A standard rodent diet; Research Diets, Inc., New Brunswick, NJ, USA, provided by Plexxikon, Inc.). One group of Cx3cr1gfp/+ mice (n = 6) had ad libitum access to PLX5622-chow 1 week before the LPS challenge and until the end of the experiment, while a second group of animals (n = 6) was fed with control chow (provided by Plexxikon, Inc.). Microglia depletion by PLX5622 was evaluated 1 week after the initiation of PLX5622 treatment with autofluorescent imaging. LPS (1 mg/kg in PBS) was administered intravenously immediately after the imaging session for four consecutive days, and mice were imaged approximately 6 h after the last LPS challenge and euthanized immediately after.
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