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591 protocols using spss ver 22

1

Factors Associated with Repeated Measures

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Mixed linear model procedures (SPSS Ver. 22) were used to identify factors associated with variation in repeated measures of CES-D, PSS and weight over time. Generalized mixed linear model procedures (SPSS Ver. 22) with the logit link function were used to model dichotomized CES-D and PSS scores. Variables associated with outcomes of interest in univariate analyses were simultaneously entered in multivariate regression models. Univariate analyses were conducted using linear and logistic regression, independent t-tests for continuous variables (with bias-corrected and accelerated confidence intervals produced by resampling procedures, when indicated) and exact tests for categorical variables. Stratified analyses of categorical analysis using Breslow-Day and Mantel-Haenszel statistics were used to assess modifiers of effects of EDS and PSS on achievement of 5% weight loss. All significance testing and confidence intervals were two-tailed and used a prior α=.05. Sidak adjustment for multiple comparisons was used when indicated.
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2

Factors Associated with Repeated Measures

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Mixed linear model procedures (SPSS Ver. 22) were used to identify factors associated with variation in repeated measures of CES-D, PSS and weight over time. Generalized mixed linear model procedures (SPSS Ver. 22) with the logit link function were used to model dichotomized CES-D and PSS scores. Variables associated with outcomes of interest in univariate analyses were simultaneously entered in multivariate regression models. Univariate analyses were conducted using linear and logistic regression, independent t-tests for continuous variables (with bias-corrected and accelerated confidence intervals produced by resampling procedures, when indicated) and exact tests for categorical variables. Stratified analyses of categorical analysis using Breslow-Day and Mantel-Haenszel statistics were used to assess modifiers of effects of EDS and PSS on achievement of 5% weight loss. All significance testing and confidence intervals were two-tailed and used a prior α=.05. Sidak adjustment for multiple comparisons was used when indicated.
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3

Factors Influencing Velopharyngeal Insufficiency

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Statistical Package for the Social Sciences (SPSS; ver. 22.0; SPSS Inc., Chicago, IL) was used for all statistical analysis. We conducted an investigation to ascertain whether variations in the incidence of VPI could be attributed to an array of factors, including sex, age at primary palatoplasty, the presence of cleft lip, cleft palate type, the specific technique employed for cleft palate repair, and the presence or absence of postoperative fistula formation. Statistical analysis was performed by summing VPI and borderline cases. The independent
t-test, analysis of variance, Welch analysis, and Logistic regression (multivariable analysis) were performed on factors with significant values using IBM SPSS ver. 22 (IBM Corp., Armonk, NY), and the relationships between subvariables were confirmed. Statistical significance was considered to be indicated by
p < 0.05.
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4

Statistical Analysis of Endoscopic Techniques

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The means and standard deviations of experimental data were calculated and analyzed with the Kruskal-Wallis test, Mann-Whitney U test, and χ2 test. A 2 × 2 table was tabulated to determine the sensitivity, specificity, and positive and negative predictive values. The χ2 test involved 2 × 2 tables, as well. The nonparametric Kruskal-Wallis Test was used in the evaluation of 3 categorical variables. The Mann-Whitney U test was used for the binary comparison between the 3 endoscopic techniques.
All P-values reported are 2-tailed and P < .05 was set as the level of significance. Statistical analyses were performed with SPSS Ver. 22.0 software (IBM Japan, Ltd., Tokyo, Japan).
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5

Standardized Experiments and IC50 Analysis

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Three replicates of the experiments were performed to evaluate the standard deviation (SD). SD and variance were designed via SPSS ver. 22.0 software (version 14, IBM, Armonk, NY, USA). IC50 depending on GraphPad Prism® software (version 5.0, Boston, USA), was calculated.
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6

Genetic Associations in Schizophrenia Subtypes

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The demographic characteristics of the healthy controls (HC), schizophrenia (SCH) group, and patients with and without TRS were compared using Student’s t-test or an ANOVA for continuous variables, and the χ2 test for categorical variables. We used the same statistical methods to compare the allelic and genotype distributions of the eight studied SNPs between the schizophrenia subgroups and the HC group. As post hoc tests, Bonferroni correction was used for the ANOVA and a residual analysis was used for the χ2 test. To explore the potential impact of each SNP on the classification of TRS or non-TRS, we conducted a multivariate logistic analysis in which we used the group (TRS, non-TRS, or HC) as the response variable and the genotype of each SNP as the explanatory variables with patient’s age and sex as covariates.
The statistical significance level was set at p < 0.05, with the exception of the comparisons of SNP distribution. For the analysis of SNP distributions, a Bonferroni correction for multiple comparisons was applied, and the statistical significance level was thus set at p = 0.00625 (=0.05/8). All statistical analyses were performed using SPSS ver. 22.0 software (IBM, NY).
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7

Statistical Analysis of Experimental Triplicates

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All experimental results were realized in triplicate. The standard deviation (SD) and variance were calculated via SPSS ver. 22.0 software (version 14, IBM Corp., Armonk, NY, USA).
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8

Statistical Analysis of TRG and RECIST Concordance

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SPSS ver. 22.0 software (IBM Corp., Armonk, NY) was used to perform statistical analysis in this study. Consistency of TRG and RECIST were analyzed using kappa statistics (kappa ≦ 0.40, poor agreement; 0.40 < kappa ≦ 0.60, moderate agreement; 0.60 < kappa ≦ 0.80, good agreement; and kappa > 0.80, excellent agreement) [17 (link)]. OS and DFS was estimated using the Kaplan-Meier method. The OS and DFS curves for different TRG groups and different RECIST groups were compared using the log-rank test. Chi-Square test or Fisher’s exact test were used as appropriate to compare the different neoadjuvant therapies as well as clinicopathological characteristics associated with different TRG groups and different RECIST groups. P values less than 0.05 were considered significant statistically.
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9

Evaluation of MyHPV Chip and HC2 for HSIL

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The concordance rates of the MyHPV chip and HC2 were evaluated using the kappa coefficient (κ) with 95% confidence intervals (CIs). The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the MyHPV chip and HC2 for ≥ HSILs were determined using standard statistical tests. The age-adjusted odds ratios (ORs) for ≥ HSILs with 95% CI were evaluated for different categories of MyHPV chip and HC2 results with a binary logistic regression using the SPSS ver. 22.0 software (IBM Co., Armonk, NY, USA). To analyze the MyHPV chip results, patients with single or multiple samples positive for 15 HR genotypes were categorized as HR-HPV (+). Patients with HPV-16 (+) and/or HPV-18 (+) were categorized as HPV-16/18 (+), irrespective of the presence of any other HPV genotypes. Patients with HPV-16 (–) and HPV-18 (–), 13 other HR-HPV (+) with or without low-risk HPV (+) or “HPV-other types” (+) were categorized as non-16/18 HR-HPV (+). Patients with low-risk HPV (+), “HPVother types” (+) or HPV (–) were categorized as HR-HPV (-). In cases of multiple infections, patients were classified based on the HPV genotypes associated with a higher risk of invasive cancer. For example, a patient with HPV-16 (+) and HPV-31 (+) was allocated to the HPV-16/18 (+) group.
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10

Comparison of ADHD and Healthy Controls

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The demographic and clinical characteristics of the ADHD and HC groups were compared using independent t-tests for continuous variables and chi-square or Fisher’s exact tests for categorical variables. Due to the predominance of boys in the ADHD group, we compared the measures between the ADHD group and HC group in boys, separately using Mann-Whitney test. We applied Spearman’s correlation analysis to investigate the correlations between ADHD clinical variables and the variables measured using the RAKMA as well as the correlation between the RAKMA stimulus–response variables and the movement variables. All statistical analyses were performed using SPSS ver. 22.0 software (IBM Corp., Armonk, NY, USA), and a p-value<0.05 was considered significant.
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