4 amino 1 butanol

Manufactured by Thermo Fisher Scientific

Sourced in Panama

4-amino-1-butanol is a chemical compound with the formula CH3(CH2)3NH2. It is a primary aliphatic amine with a four-carbon backbone. The chemical is often used as a raw material in the production of other chemical compounds, but its core function is not being interpreted or extrapolated upon in this description.

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1-butanol (34 citations) Butanol (16 citations)

6 protocols using 4 amino 1 butanol

Polymer Synthesis and Transfection Reagents

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Lipofectamine 2000 (Invitrogen, Carlsbad, CA), Opti-MEM I (Invitrogen), pEGFP-N1 DNA (Elim Biopharmaceuticals, Hayward, CA), pDsRed-Max-N1^{39 (link)} (Addgene DNA plasmid 21718, Cambridge, MA), and cell culture media components were used as received. Monomers used for synthesizing polymers (Scheme 1) were purchased as follows: 1,3-butanediol diacrylate (B3b; Sigma-Aldrich, St. Louis, MO); 1,4-butanediol diacrylate (B4; Alfa Aesar, Ward Hill, MA); 1,5-pentanediol diacrylate (B5; Monomer-Polymer and Dajac Laboratories, Trevose, PA); 3-amino-1-propanol (S3; Alfa Aesar); 4-amino-1-butanol (S4; Alfa Aesar); 5-amino-1-pentanol (S5; Alfa Aesar); 1,3-diaminopropane (E1; Sigma-Aldrich); 1,3-diaminopentane (E3; TCI America, Portland, OR); 2-methyl-1,5-diaminopentane (E4; TCI America); 1,11-diamino-3,6,9-trioxaundecane (E5; TCI America); 2-(3-aminopropylamino)ethanol (E6; Sigma-Aldrich); 1-(3-aminopropyl)-4-methylpiperazine (E7; Alfa Aesar); 1-(3-aminopropyl)pyrrolidine (E8; TCI America); and cystamine dihydrochloride (E10; Alfa Aesar). 4′,6-Diamidino-2-phenylindole dihydrochloride (DAPI) was purchased from Sigma and used as a 750 nM solution in PBS. Other materials were reagent grade.

Guerrero-Cázares H., Tzeng S.Y., Young N.P., Abutaleb A.O., Quiñones-Hinojosa A, & Green J.J. (2014). Biodegradable Polymeric Nanoparticles Show High Efficacy and Specificity at DNA Delivery to Human Glioblastoma in Vitro and in Vivo. ACS Nano, 8(5), 5141-5153.

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Synthesis and Application of Histidine-Based Conjugate

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1,4-Butanediol diacrylate (90%), 4-amino-1-butanol (98%), 4-dimethylaminopyridine (99%), N,N′-dicyclohexylcarbodiimide (99%), N-cbz-L-histidine, 10% Pd-C, methylene chloride, and ethyl ether were purchased from Alfa Aesar (Ward Hill, MA, USA). pMyD88 and the negative control plasmid containing nonspecific shRNA sequence (pHK) were both designed and synthesized by Genesil Biotechnology (Wuhan, People’s Republic of China). Sprague Dawley rats and Lewis rats weighing approximately 250 g were obtained from the Experimental Animal Center of China’s Military Academy of Medical Sciences (Beijing, People’s Republic of China). DA rats were obtained from the Experimenta Animal Center of the Second Affiliated Hospital of Harbin Medical University (Harbin, People’s Republic of China).

Hu F., Wang H., Zhang S., Peng Y., Su L., Chang J, & Liu G. (2015). Inhibition of myeloid differentiation factor 88 signaling mediated by histidine-grafted poly(β-amino ester) ester nanovector induces donor-specific liver allograft tolerance. International Journal of Nanomedicine, 10, 4367-4382.

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Reagent Synthesis for Polymer Development

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The reagents were purchased from different companies as follows: 1,4-butanediol diacrylate and 4-amino-1-butanol from Alfa Aesar (Ward Hill, MA); 1,3-diaminopropane (C1) from Sigma-Aldrich (St. Louis, MO); 2-(3-aminopropylamino)ethanol (C5) from Oakwood Chemical (West Columbia, SC); methoxy-PEG-succinimidyl succinate from JenKem Technology (Plano, TX). Solvents were purchased as follows: anhydrous ethyl ether from Fischer Scientific (Pittsburgh, PA); dimethyl sulfoxide anhydrous (DMSO) and tetrahydrofuran (THF) from Sigma-Aldrich.

Mastorakos P., Zhang C., Song E., Kim Y.E., Park H.W., Berry S., Choi W.K., Hanes J, & Suk J.S. (2017). Biodegradable brain-penetrating DNA nanocomplexes and their use to treat malignant brain tumors. Journal of controlled release : official journal of the Controlled Release Society, 262, 37-46.

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Differentiation of Neural Progenitor Cells

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Homo sapiens neurogenin-2 (Ngn2, pCMV6 vector, SC322602) and achaete-scute complex homolog 1 (Mash1, pCMV6 vector, SC117427) as transfection-ready DNAs were obtained from OriGene Technologies (Rockville, MD). pEGFP-N1 DNA was obtained from Elim Biopharmaceuticals (Hayward, CA). Recombinant fibroblast growth factor-2 (FGF-2) and epidermal growth factor (EGF) were purchased from Peprotech (Rocky Hill, NJ). Accutase was from Innovative Cell Technologies (San Diego, CA). Mouse laminin was obtained from Invitrogen (Carlsbad, CA), and 4′, 6-diamidino-2-phenylindole, dihydrochloride (DAPI) was from Molecular Probes (Eugene, OR). Primary antibodies used in this study are shown in Table S1. Fluorophore-conjugated secondary antibodies were purchased from Jackson ImmunoResearch (West Grove, PA).
Monomers used for synthesizing polymers (Scheme 1) were obtained as follows: 1,4-butanediol diacrylate (B4; Alfa Aesar, Ward Hill, MA), 1,5-pentanediol diacrylate (B5; Monomer-Polymer and Dajac Labs, Trevose, PA), 3-amino-1-propanol (S3; Alfa Aesar), 4-amino-1-butanol (S4; Alfa Aesar), 5-amino-1-pentanol (S5; Alfa Aesar), 2-(3-aminopropylamino) ethanol (E6; Sigma Aldrich, St. Louis, MO), and 1-(3-aminopropyl)-4-methylpiperazine (E7; Alfa Aesar). All other chemical reagents were from Sigma Aldrich (St. Louis, MO).

Li X., Tzeng S.Y., Liu X., Tammia M., Cheng Y.H., Rolfe A., Sun D., Zhang N., Green J.J., Wen X, & Mao H.Q. (2016). Nanoparticle-mediated Transcriptional Modification Enhances Neuronal Differentiation of Human Neural Stem Cells Following Transplantation in Rat Brain. Biomaterials, 84, 157-166.

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Multifunctional Silica Nanoparticle Synthesis

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Dimethyl
sulfoxide (DMSO, 99.9%), toluene
(99.5%), and hexane (98.5%) were purchased from BDH. Anhydrous toluene
(99.8%), Reagent Plus acetone (≥99%), Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene
glycol) (Pluronic P123, average M_n ∼5800),
tetraethyl orthosilicate (TEOS, 99.0%), N,N-diisopropylethylamine (DIPEA, 99.9%), hydrochloric acid
(37 wt %), ethanolamine (>98%), 5-amino-1-pentanol (95%), and 4-nitrobenzaldehyde
(4-NB, 98%) were obtained from Sigma Aldrich. (3-Aminopropyl)trimethoxysilane
(IPTMS, 97%), ammonium hydroxide (28 wt % in H₂O), 3-amino-1-propanol
(99%), and 4-amino-1-butanol (98%) were acquired from Alfa Aesar.
1,4-Dimethoxybenzene (DMB, >99%) was produced by Tokyo Chemical
Industry
(TCI), and ethanol (99.5%) was produced by VMR Koptec.

Xie J., Ellebracht N.C, & Jones C.W. (2019). Inter- and Intramolecular Cooperativity Effects in Alkanolamine-Based Acid–Base Heterogeneous Organocatalysts. ACS Omega, 4(1), 1110-1117.

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Polymer-Mediated Transfection of Stem Cell Regulators

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Homo sapiens SRY (sex determining region Y)-box 2 (Sox2, CMV Promoter, RG200757) and oligodendrocyte transcription factor 2 (Olig2, CMV Promoter, RG208209) as transfection-ready DNAs were obtained from OriGene Technologies (Rockville, MD). pEGFP-N1 DNA was obtained from Elim Biopharmaceuticals (Hayward, CA). Recombinant human fibroblast growth factor-2 (FGF-2) and epidermal growth factor (EGF) were purchased from Peprotech (Rocky Hill, NJ). Poly-l-lysine was obtained from ScienCell Research Laboratories (Carlsbad, CA). 4′,6-Diamidino-2-phenylindole, dihydrochloride (DAPI) was purchased from Molecular Probes (Eugene, OR). Primers and primary antibodies used in this study are shown in Tables S1 and S2,† respectively. Fluorophore-conjugated secondary antibodies were purchased from Jackson ImmunoResearch (West Grove, PA).
Monomers used for synthesizing polymers (Scheme 1) were obtained as follows: 1,4-butanediol diacrylate (B4; Alfa Aesar, Ward Hill, MA), 1,5-pentanediol diacrylate (B5; Monomer-Polymer and Dajac Labs, Trevose, PA), 3-amino-1-propanol (S3; Alfa Aesar), 4-amino-1-butanol (S4; Alfa Aesar), 5-amino-1-pentanol (S5; Alfa Aesar), 2-(3-aminopropylamino) ethanol (E6; Sigma Aldrich, St Louis, MO), and 1-(3-aminopropyl)-4-methylpiperazine (E7; Alfa Aesar). All other chemical reagents were obtained from Sigma Aldrich (St. Louis, MO).

Li X., Kozielski K., Cheng Y.H., Liu H., Zamboni C.G., Green J, & Mao H.Q. (2016). Nanoparticle-mediated conversion of primary human astrocytes into neurons and oligodendrocytes. Biomaterials science, 4(7), 1100-1112.

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