Pvp k60

2,2′−Azobisisobutyronitrile (AIBN) and Droperidol (DPD) were purchased from Merck (Vienna, Austria). 2,2,6,6−tetramethyl−1−piperinyloxy silica gel (SiliaCAT^TM TEMPO) was purchased from Silicycle Inc. (Quebec, Canada), while PVP K−60 (with an average molecular weight of 360,000 Da) was procured from Sigma Aldrich (Vienna, Austria). Ultrapure water was obtained from a TKA water purification unit. HPLC grade Methanol was procured from VWR Chemicals (Dresden, Germany). Buffer salts and other chemicals were of analytical reagent grade.

Dextrans of different M_w (kDa) (Dex 1, Dex 1.5, Dex 3.5, Dex 5, Dex 10, Dex 12, Dex 40, Dex 70 and Dex 500) were kindly supplied by Pharmacosmos A/S (Holbaek, Denmark), and PVPs of different M_w (K12, K17, K30 and K90) were kindly supplied by BASF (Ludwigshafen, Germany). PVP K60 and chloramphenicol (CAP) were sourced from Sigma Aldrich (St. Louis, MO, USA) and indomethacin (IND) was sourced from Fagron (Copenhagen, Denmark).

Celecoxib (CXB), Eudragit S100, and hydroxypropyl methylcellulose acetate succinate LG (HPMCAS-LG) were supplied by Jansen Pharmaceutica (Beerse, Belgium). Capryol 90, Maisine CC, Peceol, Plurol oleique CC 497, and Labrasol were a gift from Gattefossé (Saint-Priest Cedex, France). Captex 200 P, Captex 355 EP/NF, and Capmul PG-8 NF were a gift from ABITEC Corporation (Columbus, OH, USA). Croscarmellose sodium (AcDiSol) was obtained from FMC BioPolymer (Philadelphia, PA, USA). Tween 20, isopropyl myristate, Cremophor RH40, PEG 400, tetraglycol, Patent Blue V, Povidone (PVP) K15, PVP K60, and PVP K90 were obtained from Sigma-Aldrich (St. Louis, MO, USA). Gelatine Licaps^® size 0 capsules were gifted by Capsugel (Bornem, Belgium). Macrogolum 6000 (PEG 6000), PVP K30, hydroxypropyl methylcellulose (HPMC) 5 and 4000 cps, talc, and gelatine were obtained from BUFA (IJsselstein, The Netherlands). Tween 80, 37% fuming hydrochloric acid, sodium chloride (NaCl), sodium dodecyl sulfate (SDS), tert-butyl alcohol (TBA), sodium dihydrogen phosphate dihydrate, and sodium hydroxide (NaOH) were obtained from MERCK (Darmstadt, Germany). Acetone and ethanol 70% were purchased from BOOM B.V. (Meppel, The Netherlands) and methanol from VWR Chemicals (Fontenay-sous-Bois, France). Millipore type 1 water was used in all experiments except for the dissolution media where demineralized water was used.