The PT and aPTT were determined on an automated coagulation analyser (aPTT, pathromtin® SL; and PT, thromborel®; S BCSxp; Siemens) for patients receiving rivaroxaban. Rivaroxaban concentrations were also measured on the BCSxp, using a chromogenic assay calibrated for rivaroxaban (BIOPHEN® DiXa-I; CoaChrom Diagnostica, Neuville-sur-Oise, France).
Pathromtin
Manufactured by Siemens
Sourced in Germany
Pathromtin is a lab equipment product designed for the measurement of activated partial thromboplastin time (aPTT), a test used to assess the intrinsic and common coagulation pathways. It is used in clinical laboratories for the evaluation of coagulation disorders and monitoring of anticoagulant therapy.
Automatically generated - may contain errors
Lab products found in correlation
3 protocols using pathromtin
1
Rivaroxaban Pharmacokinetics Evaluation
2
Coagulation Assays Protocol
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APTT (seconds), international normalized ratio (INR) (ratio, [no unity]), fibrinogen (µmol/L), and antithrombin (IU/ml) assays were performed on the ACL Top 500 (Instrumentation Laboratory, Milano, Italy) with dedicated reagents for INR, fibrinogen, and antithrombin, and the reagent Pathromtin (Siemens, Erlangen, Germany) for APTT.
3
Blood Coagulation Biomarker Measurement
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Blood samples were collected from the antecubital vein into 0.109 mol/l trisodium citrate tubes (Vacutainer, Becton Dickinson, New Jersey, USA) in the morning, after an overnight fasting. Plasma samples were obtained by centrifuging blood at 2000 Â g for 15 min at room temperature for von Willebrand factor (vWF)-ag, fibrinogen, FVIII and at 4 8C only for PAI-1 evaluation. Complete blood cell count was performed by using the Sysmex XE-2100 hematology analyzer (Sysmex, Kobe, Japan). Fibrinogen was assessed by Clauss clotting method (Siemens, Marburg, Germany). Plasma PAI-1 antigen levels were measured with commercially available ELISA kits (PAI-1 Actibind ELISA, Technoclone, Wien, Austria). FVIII activity was determined by a coagulation-based assay, with deficient plasma in the presence of Pathromtin (Coagulation Factor VIII, Siemens); vWF antigen levels were detected by a turbidimetric assay (vWFAg, Siemens).
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