We evaluated the GSE41258 gene expression dataset to identify promising early targets for imaging that are overexpressed in colonic adenomas compared to normal.29 (link) We analyzed 22,283 probe-sets using the Affymetrix HG_U133A array platform. Data from n = 52 normal and n = 45 adenomas were selected. Two-sample t-tests and average fold-changes were computed. Data was evaluated based on the following criteria: P-value<10−5, average fold-change >2, and location on plasma membrane using Gene Ontology (GO) terms obtained from Affymetrix (ver na32).
Hg u133a array platform
Manufactured by Thermo Fisher Scientific
The HG_U133A array platform is a high-density oligonucleotide microarray designed for gene expression analysis. It contains probes that interrogate approximately 22,000 well-characterized human genes. The array provides a comprehensive and quantitative analysis of gene expression in a single experiment.
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Lab products found in correlation
2 protocols using hg u133a array platform
1
Identifying Colonic Adenoma Biomarkers
2
Colonic Adenoma Biomarker Identification
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We evaluated the GSE41258 gene expression data set to identify promising early targets for imaging that are overexpressed in colonic adenomas compared with normal.29 (link) We analyzed 22,283 probe-sets using the Affymetrix (Santa Clara, CA) HG_U133A array platform. Data from N = 52 normal and N = 45 adenomas were selected. Two-sample t tests and average fold-changes were computed. Data were evaluated based on the following criteria: P value less than 10-5, average fold-change greater than 2, and location on plasma membrane using Gene Ontology terms obtained from Affymetrix (ver na32).
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