M salicylic acid

Example 1

Synthesis of nicotine meta-salicylate: 1.385 g m-salicylic acid (Sigma Aldrich) was dissolved in 25 ml of ethanol. 1.62 g nicotine was added drop wise at room temperature and mixed well for approx. 30 minutes. The solution was rotary evaporated slowly to reduce the volume to about 10 ml. Then 5 ml of ethyl acetate was added and stirred for 3-5 minutes. The solution was placed on dry ice for approx. 1.5 hours, which produced a sticky solid material. After evaporation of the solvent, 20 mL ethanol was added to dissolve the sticky solid and then evaporated. This recrystallization in known in the art for purifying crystals. Crystalline solid remained in the flask. The powder was removed from the flask and dried in a vacuum oven at 40° C. 2.6 grams were recovered (approx. 87% yield). The melting point of the solid was 125° C.

Example 1

Synthesis of nicotine meta-salicylate: 1.385 g m-salicylic acid (Sigma Aldrich) was dissolved in 25 ml of ethanol. 1.62 g nicotine was added drop wise at room temperature and mixed well for approx. 30 minutes. The solution was rotary evaporated slowly to reduce the volume to about 10 ml. Then 5 ml of ethyl acetate was added and stirred for 3-5 minutes. The solution was placed on dry ice for approx. 1.5 hours, which produced a sticky solid material. After evaporation of the solvent, 20 mL ethanol was added to dissolve the sticky solid and then evaporated. This recrystallization in known in the art for purifying crystals. Crystalline solid remained in the flask. The powder was removed from the flask and dried in a vacuum oven at 40° C. 2.6 grams were recovered (approx. 87% yield). The melting point of the solid was 125° C.