Ruboxistaurin

Manufactured by Merck Group

Sourced in United States

Ruboxistaurin is a laboratory compound developed by Merck Group. It is a chemical entity that can be used in research and development applications. The core function of Ruboxistaurin is to serve as a tool compound for scientific investigation, without any interpretation or extrapolation on its intended use.

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Lab products found in correlation

Enzastaurin, by Selleck Chemicals (1 mentions) At7519, by Selleck Chemicals (1 mentions) Tozasertib, by Selleck Chemicals (1 mentions) Chelerythrine, by Merck Group (1 mentions) Safingol, by Merck Group (1 mentions) Anti jnk antibody, by Cell Signaling Technology (1 mentions) Anti pkcδ antibody, by Santa Cruz Biotechnology (1 mentions) Sp600125, by Merck Group (1 mentions) Indomethacin, by Merck Group (1 mentions) L name, by Merck Group (1 mentions) Go6976, by Merck Group (1 mentions)

2 protocols using ruboxistaurin

High-Throughput Kinase Inhibitor Screening

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CHIR-99021 (synthesized at Broad Institute), Enzastaurin (Selleck Chemicals), Ruboxistaurin (Sigma), AT7519 (Selleck Chemicals), Tozasertib (Selleck Chemicals) and CGP-60474 (Tocris). The HMS LINCS kinase inhibitor library was supplied to us as 2 µL 10 mM compound/well custom-arrayed in NUNC 96-well plate by the ICCB-Longwood Screening Facility.

Cheng C., Reis S.A., Adams E.T., Fass D.M., Angus S.P., Stuhlmiller T.J., Richardson J., Olafson H., Wang E.T., Patnaik D., Beauchamp R.L., Feldman D.A., Silva M.C., Sur M., Johnson G.L., Ramesh V., Miller B.L., Temple S., Kosik K.S., Dickerson B.C, & Haggarty S.J. (2021). High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy. Scientific Reports, 11, 17029.

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Modulation of JNK Signaling in Tissues

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All drugs were of the highest purity available commercially. L-NAME, indomethacin, chelerythrine, Go6976, safingol, ruboxistaurin, and SP600125 were obtained from Sigma-Aldrich (St. Louis, MO, USA). Rottlerin and ML-7 hydrochloride were purchased from Calbiochem (San Diego, CA, USA). DMT was donated by Orion Pharma (Turku, Finland). Anti-phospho-stress activated protein kinase/JNK (Thr183/Tyr185) and anti-JNK antibodies were obtained from Cell Signaling Technology (Beverly, MA, USA). Anti-PKC-δ antibody was purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA). indomethacin, Go6976, safingol, rottlerin, ruboxistaurin, and SP600125 were dissolved in dimethyl sulfoxide (final organ bath concentration: 0.1%). All other drugs were dissolved and diluted in distilled water unless otherwise stated.

Yu J., Ok S.H., Kim W.H., Cho H., Park J., Shin I.W., Lee H.K., Chung Y.K., Choi M.J., Kwon S.C, & Sohn J.T. (2015). Dexmedetomidine-Induced Contraction in the Isolated Endothelium-Denuded Rat Aorta Involves PKC-δ-mediated JNK Phosphorylation. International Journal of Medical Sciences, 12(9), 727-736.

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