Liproxstatin 1

Manufactured by Targetmol

Sourced in China

Liproxstatin-1 is a small molecule compound that functions as a potent and selective inhibitor of ferroptosis, a form of programmed cell death. It acts by blocking the activity of the enzyme 15-lipoxygenase, which plays a key role in the initiation of ferroptosis.

Automatically generated - may contain errors

Lab products found in correlation

Bafilomycin a1, by Selleck Chemicals (1 mentions) Necrosulfonamide, by Targetmol (1 mentions) Z vad fmk, by Targetmol (1 mentions) Ferrostatin 1, by Targetmol (1 mentions) Erastin, by Selleck Chemicals (1 mentions) Chip assay kit, by Beyotime (1 mentions) Aldefluor kit, by STEMCELL (1 mentions) Epidermal growth factor (egf), by Thermo Fisher Scientific (1 mentions) Insulin, by Merck Group (1 mentions) Human dkk1 quantikine elisa kit, by R&D Systems (1 mentions) Xav 939, by Targetmol (1 mentions) Chir99021, by Targetmol (1 mentions) Erastin, by MedChemExpress (1 mentions)

2 protocols using liproxstatin 1

Ferroptosis Inhibitors and Inducers

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Ferrostatin-1(T6500), Liproxstatin-1(T2376), Deferoxamine(DFO, T1637), Z-VAD-FMK(T6013), Necrosulfonamide(T7129) and 5-FU(T0984) were obtained from TargetMol (Shanghai, China). BafilomycinA1(S1413) and Erastin(S7242) were obtained from Selleck (Houston, TX, USA). The Synthetic methods and Routes of W1131 are described in detail in Supplemental Information.

Ouyang S., Li H., Lou L., Huang Q., Zhang Z., Mo J., Li M., Lu J., Zhu K., Chu Y., Ding W., Zhu J., Lin Z., Zhong L., Wang J., Yue P., Turkson J., Liu P., Wang Y, & Zhang X. (2022). Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer. Redox Biology, 52, 102317.

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Inhibiting DKK1 Signaling for Stem Cell Regulation

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For DKK1 Inhibitors, Gallocyanine was from Santa Cruz, WAY262611 was from TargetMol. STAT3 inhibitor III (WP1066) was from Santa Cruz. EGF and bFGF recombinant proteins were from PeproTech. The DKK1 recombinant protein was purchased from Abcam. Insulin was purchased from Sigma-Aldrich. The Wnt/β-catenin pathway inhibitor XAV939 and activator CHIR99021 were from TargetMol. The ferroptosis inducer Erastin and RSL3 were from MedChem Express. The liproxstatin-1 was from TargetMol. BODIPY-C11 (D3861) was from ThermoFisher. ALDEFLUOR™ Kit (Cat#01700) was from Stem Cell. ChIP Assay Kit (Cat#P2078) was from Beyotime. Human DKK1 Quantikine ELISA Kit (Cat#DKK100B) were from R&D System.

Wu M., Zhang X., Zhang W., Chiou Y.S., Qian W., Liu X., Zhang M., Yan H., Li S., Li T., Han X., Qian P., Liu S., Pan Y., Lobie P.E, & Zhu T. (2022). Cancer stem cell regulated phenotypic plasticity protects metastasized cancer cells from ferroptosis. Nature Communications, 13, 1371.

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