4 5 6 7 tetrahydroisoxazolo 5 4 c pyridin 3 ol thip

Manufactured by Merck Group

Sourced in United States

4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol (THIP) is a chemical compound used in laboratory research. It is a heterocyclic organic molecule with a specific molecular structure and formula. THIP serves as a tool for scientific investigations, but its precise core function is not specified in this factual and unbiased description.

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Lab products found in correlation

Isoguvacine, by Merck Group (1 mentions) Gaboxadol, by Merck Group (1 mentions) β alanine, by Merck Group (1 mentions) Pcdna1, by Thermo Fisher Scientific (1 mentions) 5 aminovaleric acid, by Merck Group (1 mentions) Glycine, by Merck Group (1 mentions) Picrotoxin, by Merck Group (1 mentions) Cgp 55845a, by Bio-Techne (1 mentions) Sr95531, by Merck Group (1 mentions)

2 protocols using 4 5 6 7 tetrahydroisoxazolo 5 4 c pyridin 3 ol thip

Recombinant Expression of Human GABA Receptor

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Human ρ1 cDNA subcloned into pcDNA1.1 (Invitrogen, San Diego, CA, USA) was kindly provided by Dr. George Uh1 (National Institute for Drug Abuse, Baltimore, MD, USA).
(GABA, 5-aminovaleric acid, β-alanine, glycine, isoguvacine, 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol (THIP) also known as Gaboxadol, were purchased from Sigma-Aldrich (Sigm-Aldrich Pty Ltd, Castle Hill, NSW 1765 Australia). 1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid (TPMPA) [31 (link)], trans-aminocrotonic acid (TACA) and cis-aminocrotonic acid (CACA) [32 (link)], and 2-aminoethylmethane thiosulfonate (MTSEA) [33 (link)] were prepared as previously reported.

Naffaa M.M., Absalom N., Solomon V.R., Chebib M., Hibbs D.E, & Hanrahan J.R. (2016). Investigating the Role of Loop C Hydrophilic Residue ‘T244’ in the Binding Site of ρ1 GABAC Receptors via Site Mutation and Partial Agonism. PLoS ONE, 11(5), e0156618.

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Neurotransmitter Receptor Modulators

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DNQX (10 μm), AP-5 (50 μm), and CGP55845A (1 μm) were purchased from Tocris Bioscience. SR-95 531 [gabazine (GBZ); 100 μm], picrotoxin (100 μm), and 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol (THIP; 1–10 μm) were purchased from Sigma-Aldrich.

Agoglia A.E., Zhu M., Ying R., Sidhu H., Natividad L.A., Wolfe S.A., Buczynski M.W., Contet C., Parsons L.H., Roberto M, & Herman M.A. (2020). Corticotropin-Releasing Factor Receptor-1 Neurons in the Lateral Amygdala Display Selective Sensitivity to Acute and Chronic Ethanol Exposure. eNeuro, 7(2), ENEURO.0420-19.2020.

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