Cmc assist software

Manufactured by Bruker

CMC-assist software is a data processing and analysis tool developed by Bruker. It is designed to assist with the characterization of complex molecular structures, including small molecules, peptides, and proteins. The software provides functionalities for the processing and interpretation of data from various analytical techniques, such as nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry, and chromatography.

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Lab products found in correlation

Deuterated chloroform, by Bruker (1 mentions) Av 300 nmr spectrometer, by Bruker (1 mentions) Freezone 2.5 liter 84 c benchtop freeze dryer, by Labconco (1 mentions) Economy nmr tubes, by Wilmad (1 mentions)

2 protocols using cmc assist software

Assessment of Diclofenac-Andrographolide Combination

Cited 2 times

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Diclofenac was the NSAID of choice for combination due to its widespread use and relative safety at low doses.^{28 (link)} Additionally, andrographolide was used in the combination with diclofenac since it has been shown to possess protective effect in the gastrointestinal tract, liver, and kidney and also has analgesic properties.^{17 (link),18} Doses selected for ED₅₀ determination of both diclofenac and andrographolide were based on notes from previous literature and selected route of administration.^{17 (link),18 ,29 (link)} All drugs were prepared in normal saline with tween-80 added for adequate dispersion of andrographolide (1 drop of tween-80 for every 10 mL of saline). Calculations for preparation of solutions were such that maximum volume of final solution administered to each 150 g rat was not more than 1.5 mL. Normal saline with tween-80 (1 drop of tween-80 per 10 mL of saline) was used as the vehicle and given at a dose not exceeding 10 mL/kg to rats. Purity of diclofenac and andrographolide samples used in this study was confirmed by NMR analysis with the aid of Bruker CMC-assist software (see supplementary material 3, Sup Fig 1).

Tandoh A., Danquah C.A., Benneh C.K., Adongo D.W., Boakye-Gyasi E, & Woode E. (2022). Effect of Diclofenac and Andrographolide Combination on Carrageenan-Induced Paw Edema and Hyperalgesia in Rats. Dose-Response, 20(2), 15593258221103846.

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Lyophilization of Nanoparticle Samples

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1 mL non-loaded nanoparticles were frozen at −80°C and lyophilized to a powder in a FreeZone 2.5 Liter −84°C Benchtop Freeze Dryer (Labconco). Powdered nanoparticles were dissolved in 600 μL deuterated chloroform (MilliporeSigma) and added to 5 mm outer diameter economy NMR tubes (Wilmad-LabGlass). One sample per condition tested was scanned for 1H shifts relative to deuterated chloroform with a Bruker AV-300 NMR spectrometer. Measurements were run with 32 scans, recycle delay of 8, sweep width of 15, and time domain of 64k. Spectra were analyzed in Bruker CMC-assist software.

Liao R., Pon J., Chungyoun M, & Nance E. (2020). Enzymatic protection and biocompatibility screening of enzyme-loaded polymeric nanoparticles for neurotherapeutic applications.. Biomaterials, 257, 120238.

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