Fluorescein isothiocyanate (fitc)

glucose oxidase (GOx, 200 u/mg), Tirapazamine (TPZ), 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) and 4,6-diamidino-2-phenylindole (DAPI) were purchased from Sigma-Aldrich. Zinc nitrate (Zn(NO₃)₂ 6H₂O), catalase (100 u/mg), H₂O₂, 2-methylimidazole, fluorescein isothiocyanate (FITC), 3,3,3',3'-tetramethylindodicarbocyanine perchlorate (DiD), glucose, titanium oxysulfate (TiOSO₄·XH₂SO₄·8H₂O), sulfuric acid (H₂SO₄), and acetone were acquired from Sinopharm Chemical Reagent co. LTD. Fetal bovine serum (FBS) and Dulbecco's modified eagle medium (DMEM) with low glucose (1 g L^-1) were bought from Gibco BRL (Eggenstein, Germany). Milli-Q water (18.2 MΩ·cm) was obtained from the Milli-Q System (Millipore, Bedford, MA, USA).

The following chemicals were used as received: mono-(6-amino-6-deoxy)-beta-cyclodextrin was bought from Shandong Binzhou Zhiyuan Biotechnology Co., Ltd (Binzhou, China). Hyaluronic acid (HA, 95%), fluoresceinisothiocyanate (FITC, purity > 90%, Mw = 389.40), fluorescein sodium, phosphate buffer solution (PBS) and Arginylglycylaspartic acid(RGD) peptides-FITC (FITC-RGD & FITC-RGD-Ad) modified with fluoresceinisothiocyanate were obtained from Sinopharm Chemical Reagent Beijing Co., Ltd (Beijing, China). Cetyltrimethylammonium bromide surfactant (CH₃(CH₂)₁₅N(CH₃)₃Br, CTAB), tetraethoxysilane (TEOS) and Poly(allylamine hydrochloride) (PAH, Mw = 15,000) were purchased from Sigma-Aldrich. 4,4′-diazostilbene-2,2′-disulfonic acid disodium salt (DAS), N-Hydroxysuccinimide (NHS) and 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) were purchased from Tokyo Chemical Industry (Shanghai) Development Co., Ltd (Shanghai, China). Only Ultra-pure water was used, in this study.

CDDP was purchased from Shanghai yuanye Bio-Technology Co., Ltd. (Shanghai, China). α-tocopheryl succinate (TOS), AgNO₃ and O-phenylenediamine (OPDA) were obtained from Sigma-Aldrich Co., Ltd. (Steinheim, Germany). Fluorescein isothiocyanate (FITC) was purchased from Sinopharm Chemical Reagent Co., Ltd. Hoechst 33342, 2′,7′-dichlorofluorescein diacetate (DCFH-DA), Annexin V-FITC/PI Apoptosis Detection Kit and Mitochondrial membrane potential assay kit with JC-1 were all purchased from Beyotime Biotechnology Co., Ltd. (Shanghai, China). Roswell Park Memorial Institute (RPMI) 1640 medium, fetal bovine serum and penicillin-streptomycin were ordered from Life Technologies Corporation (Gibco, USA) and directly used for cells tests. Human non-small cell lung cancer cell line (A549) was purchased from the Chinese Academy of Science cells Bank (Shanghai, China).